Shiseido Benefiance Wrinkle Smoothing Eye Cream for mature skin

Questions and answers

What the research says

• Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.

  Journal of Cosmetic Dermatology, 2026

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.

  Journal of Cosmetic Dermatology, 2015

• Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo.

  Experimental Dermatology, 2009

• Topical application of a vitamin C-squalene bioconjugate significantly increased epidermal thickness, type III collagen production, and glycosaminoglycans production in human skin explants compared to free vitamin C and vitamin C-palmitate.

  Scientific Reports, 2020

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks.

  International Journal of Cosmetic Science, 2011

• Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects.

  Frontiers in Physiology, 2019

• Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid.

  AAPS PharmSciTech, 2021

• Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.

  International Journal of Cosmetic Science, 2026

• Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties.

  Skin Pharmacology and Physiology, 2023

• Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models.

  Drug Discovery Today, 2017

• A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation.

  Saudi Pharmaceutical Journal, 2024

Ingredients

Water, Hydrogenated Polydecene, Glycerin, Paraffinum Liquidum Huile Minerale Mineral Oil, Petrolatum, Butylene Glycol, Paraffin, Polyglyceryl-2 Diisostearate, Squalane, Glyceryl Oleate, Sodium Pca, Glutamic Acid, Dipropylene Glycol, Carnosine, Beeswax Cera Alba Cire Dabeille Cera, Microcrystalline Wax Cera Microcristallina Cire Microcristalline Wax Cera, Sodium Hydroxide, Alcohol, Polyethylene, Methylparaben, Tocopheryl Acetate, Ethylparaben, Phytosteryl Octyldodecyl Lauroyl Glutamate, Parfum, Trisodium Edta, Tocopherol, Sodium Metabisulfite, Caffeine, Iron Oxides Ci 77492, Peg Ppg-14 7 Dimethyl Ether, Ppg-3 Dipivalate, Linalool, Limonene, Citronellol, Geraniol, Alpha-Isomethyl Ionone, Sanguisorba Officinalis Root Extract, Crataegus Monogyna Flower Extract, Camellia Sinensis Leaf Extract, Sodium Acetylated Hyaluronate, Hydroxyproline, Iron Oxides Ci 77491, Citrus Junos Seed Extract, Cinnamomum Cassia Bark Extract, Ziziphus Jujuba Fruit Extract, Chlorella Vulgaris Extract, Eucheuma Serra Grateloupia Sparsa Saccharina Angustata Ulva Linza Undaria Pinnatifida Extract, Carbomer, Sodium Lactate, Bht, Curcuma Longa Extract Rhizome, Polysorbate 20, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.