The Ordinary Argireline Solution 10% for sensitive skin
Acetyl Hexapeptide-8
Propanediol
Gellan Gum
Phenoxyethanol
Sodium Chloride
Average
- HighNormal Skin Fit
- AverageEffectiveness
- ConcerningSafety
Works for sensitive skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Suitable for normal skin, this formula utilizes acetyl hexapeptide-8 to offer moderate plumping and improve elasticity, while propanediol provides essential hydration.
- The product offers supportive benefits for redness and irritation, though it lacks specialized ingredients like niacinamide or centella asiatica that could more directly address your sensitivity.
How to apply
- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
People Say
★4.3Overall rating based on 2.5k+ reviewsBased on a very large amount of data, users frequently describe this serum as "Botox in a bottle," praising its ability to soften dynamic facial lines, particularly on the forehead and around the eyes. While many with mature or expressive skin report smoother texture and reduced wrinkle depth with consistent use, a notable portion of users saw no visible difference, suggesting efficacy varies significantly by skin type and depth of lines.
Highlights
Softens dynamic lines Mostly Mentioned
- “Softened my deep forehead lines”
- “Noticed my 11s are less prominent”
- “Crow's feet look much smoother”
- “Forehead feels tighter and smoother”
Affordable price point Often Mentioned
- “Unbeatable price for peptides”
- “Great value for the results”
- “Cheap enough to use liberally”
- “Wallet-friendly anti-aging”
Lightweight watery texture Often Mentioned
- “Feels like water on the skin”
- “Absorbs instantly with no residue”
- “Layers perfectly under makeup”
- “Completely weightless and non-sticky”
Gentle and non-irritating Sometimes Noted
- “Did not irritate my sensitive eyes”
- “No stinging or redness”
- “Gentle enough for daily use”
- “Great alternative to harsh actives”
No visible results Sometimes Noted
- “Did absolutely nothing for my lines”
- “Finished the bottle with no difference”
- “Just felt like putting water on my face”
- “Zero improvement after 3 months”
Too runny/watery Sometimes Noted
- “Runs right off my fingers”
- “Hard to control the drops”
- “Spills everywhere because it's so thin”
- “Too watery to apply precisely”
Packaging issues Rarely Noted
- “Cap doesn't screw on tight”
- “Dropper stopped working”
- “Bottle leaked in my bag”
- “Crusty residue around the rim”
Results take time Rarely Noted
- “Took 2 months to see a change”
- “Must use twice daily or it stops working”
- “Slow progress, requires patience”
- “Results fade immediately if you stop”
Sources: lovi.care, sephora.com, theordinary.com, ulta.com, cultbeauty.co.uk, influenster.com, and more
Questions and answers
How well does The Ordinary Argireline Solution work for sensitive skin?
The Ordinary Argireline Solution 10% works as an average fit for sensitive skin, offering supportive benefits for redness and irritation alongside moderate plumping from acetyl hexapeptide-8 and hydration from propanediol. However, because it lacks specialized ingredients like niacinamide or centella asiatica to more directly address sensitivity, a treatment for this skin needs soothing ingredients, potent antioxidants, and skin-repairing components to deliver optimal results safely.
American Journal of Clinical Dermatology, 2013International Journal of Cosmetic Science, 2024
Which ingredients make this serum a good fit for sensitive skin?
Acetyl Hexapeptide-8 and propanediol make this serum work for sensitive skin by offering moderate plumping and hydration. Treatments that fit sensitive skin better need calming ingredients like niacinamide or centella asiatica to directly address redness and irritation.
International Journal of Cosmetic Science, 2024American Journal of Clinical Dermatology, 2013
What does Argireline do for sensitive skin?
Argireline is unlikely to cause irritation and is sometimes found in products designed to calm reactive skin. Studies show it helps smooth the look of wrinkles and decrease skin roughness when used consistently.
American Journal of Clinical Dermatology, 2013Pharmaceuticals, 2021
What does Propanediol do for sensitive skin?
Propanediol helps increase skin hydration and keeps the skin barrier strong, which is especially helpful for keeping sensitive skin feeling calm and smooth. It has a very safe profile and is unlikely to cause irritation when applied to the skin.
Where does this serum go in a skincare routine for sensitive skin?
This serum goes in your evening routine after your soothing toner and before your moisturizer. It works for sensitive skin by offering moderate plumping and hydration, though this skin type needs a product with ingredients like niacinamide or centella asiatica to more directly address redness and irritation.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the treatment first and following with your retinol product, but this formula lacks specialized soothing ingredients like niacinamide or centella asiatica that could better protect sensitive skin.
How often should I use this serum?
You can use this treatment in your evening routine, applying it after your toner and before your moisturizer. While it works for sensitive skin, a product for this skin needs soothing ingredients like niacinamide or centella asiatica to better calm redness and irritation.
Can this serum clog pores, cause breakouts or purging for sensitive skin?
This serum is unlikely to clog pores or cause breakouts for sensitive skin. Its lightweight, water-based formula absorbs easily without heavy oils that typically trigger blemishes.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits.
International Journal of Cosmetic Science, 2024Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.
European Journal of Neurology, 2013Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days.
Molecules, 2021Sustainable cosmetic products formulated with renewable PDO-based emulsifiers showed equivalent performance in sensory and moisturization evaluations compared to those formulated with petroleum-derived PEG-based emulsifiers.
Journal of Cosmetic Science, 2017Gellan gum hydrogel films co-encapsulating ofloxacin with tea tree or lavender oil achieved 98% wound contraction and completely healed epidermis in rats after ten days of treatment compared to baseline.
International Journal of Biological Macromolecules, 2021Oleuropein-rich gellan gum and sodium alginate hydrogel films acted as effective antioxidant and photoprotectant treatments against UVA-induced photoaging in normal human dermal fibroblasts.
Molecules, 2023Glycerol crosslinked vitamin E loaded xanthan gum and gellan gum nanoemulgels scavenged 88.5% of free radicals, reduced transepidermal water loss by up to 33.3%, and improved moisture content and skin structural characteristics in a murine dry skin model.
International Journal of Biological Macromolecules, 2025Calcium hydroxylapatite diluted with normal saline combined with microfocused ultrasound with visualization improved age-related changes in the lower face, neck, and décolleté and stimulated collagen and elastin fibers in 20 subjects.
Journal of Drugs in Dermatology, 2020Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two.
Auris, Nasus, Larynx, 2020Topical application of magnetized saline water serum improved skin hydration, reduced transepidermal water loss, sebum content, melanin index, and erythema index, and activated autophagy by increasing Beclin-1 and decreasing mTOR in females wanting to enhance facial and neck skin appearance.
Cureus, 2023
Why other serums fit sensitive skin better
Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.
European Journal of Pharmaceutics and Biopharmaceutics, 2016In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle.
Skin Pharmacology and Physiology, 2026Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid serum decreased postoperative edema and erythema and increased basic fibroblast growth factor expression in fifteen healthy adults compared to vehicle control.
Lasers in Surgery and Medicine, 2016
Ingredients
Water, Propanediol, Acetyl Hexapeptide-8, Trisodium Ethylenediamine Disuccinate, Gellan Gum, Sodium Chloride, Isoceteth-20, Dimethyl Isosorbide, Potassium Sorbate, Phenoxyethanol, Chlorphenesin, Ethoxydiglycol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
-
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
-
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
-
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
-
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
-
Medical Board
Cosmetic chemist, SCS, IFSCC member
-
Medical Board, Medical Advisor
Dermatology MD
-
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
-
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.