Shiseido Essential Energy Hydrating Cream for skin with dark spots

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo.

  Polymers, 2023

• Liposomal formulation of 3-O-ethyl-L-ascorbic acid enhanced skin retention and reduced UV-induced extracellular matrix degradation in skin explants compared to free EAA.

  Journal of Liposome Research, 2025

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects.

  Rejuvenation Research, 2015

• A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects.

  Journal of Ginseng Research, 2022

• A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline.

  Journal of Toxicology and Environmental Health. Part A, 2020

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Topical application of Citrus reticulata fruit extract provided instant relief from lactic acid-induced skin discomfort and increased skin tolerance by inhibiting TRPV1 activation and expression.

  Journal of Cosmetic Dermatology, 2023

• Fermented Citrus unshiu peel extract inhibited MMP-1 expression and decreased SA-beta-gal positive cells by approximately 45% at 0.1% concentration in ultraviolet-A-irradiated human dermal fibroblasts compared to untreated irradiated cells.

  Phytotherapy Research, 2012

Ingredients

Water, Dimethicone, Butylene Glycol, Alcohol Denat, Betaine, Glycerin, Isohexadecane, Hydrogenated Polydecene, Ppg-3 Dipivalate, Silica, Behenyl Alcohol, Stearyl Alcohol, Myristyl Myristate, Glyceryl Stearate Se, Polysorbate 60, Peg-100 Stearate, Peg Ppg-14 7 Dimethyl Ether, Peg Ppg-17 4 Dimethyl Ether, Phenoxyethanol, Dimethylacrylamide Sodium Acryloyldimethyltaurate Crosspolymer, Titanium Dioxide Ci 77891, Sorbitan Tristearate, Erythritol, Parfum, Alcohol, Aminopropyl Dimethicone, 2-O-Ethyl Ascorbic Acid, Carbomer, Trisodium Edta, Xanthan Gum, Caffeine, Potassium Hydroxide, Isostearic Acid, Sodium Metaphosphate, Phytosteryl Octyldodecyl Lauroyl Glutamate, Aluminum Hydroxide, Linalool, Tocopherol, Sodium Metabisulfite, Limonene, Citrus Unshiu Peel Extract, Sodium Hyaluronate, Angelica Keiskei Stem Extract Leaf, Ziziphus Jujuba Fruit Extract, Panax Ginseng Root Extract, Sodium Acetylated Hyaluronate, Scutellaria Baicalensis Root Extract, Iron Oxides Ci 77491, Alpinia Speciosa Leaf Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Sanguisorba Officinalis Root Extract, Pyrola Incarnata Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.