Shiseido Bio-Performance Skin Filler for skin with dark spots

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.

  Journal of Cosmetic Dermatology, 2020

• Lavandula angustifolia leaf callus extract enhanced skin cell viability, reduced oxidative stress and melanin content, improved wound healing, and enhanced skin barrier function in human skin cells and clinical tests.

  Free Radical Biology & Medicine, 2025

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Polysaccharide-based O/W emulsions incorporated with lavender essential oil applied to cellulosic support are non-irritating, provide softness and moisturizing effects, and are safe for topical patch applications.

  International Journal of Biological Macromolecules, 2021

• Gellan gum hydrogel films co-encapsulating ofloxacin with tea tree or lavender oil achieved 98% wound contraction and completely healed epidermis in rats after ten days of treatment compared to baseline.

  International Journal of Biological Macromolecules, 2021

• Topical application of lavender oil significantly promoted wound contraction, collagen synthesis, and fibroblast differentiation with up-regulation of TGF-beta in a rat model compared to control.

  BMC Complementary and Alternative Medicine, 2016

• Daily topical application of a combination of Trifolium pratense flower extract and a biomimetic peptide increased anagen hair by 13%, decreased telogen hair density by 29%, and increased the anagen/telogen ratio by 46% over baseline in 30 volunteers with receding hair compared to placebo over 4 months.

  Journal of Cosmetic Science, 2013

• A water-in-oil microemulsion vehicle significantly enhanced the intradermal delivery of genistein, daidzein, and biochanin A in excised guinea pig and Yucatan micropig skin, with genistein exhibiting the most marked increase in skin accumulation and effectively preventing UV irradiation-induced erythema formation.

  Chemical & Pharmaceutical Bulletin, 2010

• Topical administration of Trifolium pratense extract ointment significantly increased collagen production, epidermis thickness, fibroblast distribution, wound contraction, and Bcl-2 mRNA levels while reducing Bax and p53 mRNA levels in Wistar rats compared to non-intervention controls.

  Biotechnic & Histochemistry, 2021

Ingredients

Water, Dimethicone, Butylene Glycol, Dipropylene Glycol, Alcohol, Glycerin, Behenyl Alcohol, Triethylhexanoin, Silica, Phytosteryl Octyldodecyl Lauroyl Glutamate, Alpha-Glucan Oligosaccharide, Aminopropyl Dimethicone, Trifolium Pratense Flower Extract, Lavandula Angustifolia Oil Lavender Oil, Bupleurum Falcatum Root Extract, Batyl Alcohol, Hydrogenated Palm Oil, Behenic Acid, Elaies Guineensis Kernel Oil Palm Kernel Oil, Peg-60 Glyceryl Isostearate, Peg-10 Dimethicone, Elaies Guineensis Oil Palm Oil, Tocopherol, Sodium Metaphosphate, Potassium Hydroxide, Sodium Metabisulfite, Cinnamomum Cassia Bark Extract, Citric Acid, Phenoxyethanol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.