Shiseido Bio-Performance Advanced Super Revitalizing Cream for sensitive skin

How to apply

Questions and answers

What the research says

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.

  Journal of Cosmetic Dermatology, 2020

• Topical raspberry ketone increased dermal IGF-I production through sensory neuron activation, promoting hair growth and increasing skin elasticity in mice and humans.

  Growth Hormone & IGF Research, 2008

• A liposoluble extract of Rubus idaeus cell cultures induced genes for skin hydration, stimulated ceramide production, increased extracellular matrix synthesis in cultured fibroblasts, and showed skin-hydrating capacity in vivo.

  International Journal of Cosmetic Science, 2015

• Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

  Journal of Cosmetic Dermatology, 2025

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

  Journal of Cosmetic Dermatology, 2024

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

Ingredients

Water, Glycerin, Butylene Glycol, Isododecane, Isohexadecane, Dimethicone, Cetyl Ethylhexanoate, Hydrogenated Polydecene, Disteardimonium Hectorite, Peg-9 Polydimethylsiloxyethyl Dimethicone, Peg-150, Peg-8 Diisostearate, Phenoxyethanol, Methylparaben, Ethylparaben, Phytosteryl Macadamiate, Sodium Citrate, Parfum, Trisodium Edta, Tocopheryl Acetate, Stearyl Glycyrrhetinate, Hydroxyproline, Citric Acid, Sodium Metaphosphate, Benzyl Benzoate, Alpha-Isomethyl Ionone, Butylphenyl Methylpropional, Hexyl Cinnamal, Linalool, Limonene, Sodium Acetylated Hyaluronate, Citronellol, Geraniol, Saccharomyces Lysate Ferment Filtrate, Rubus Idaeus Fruit Extract Raspberry Fruit Extract, Iron Oxides Ci 77492, Syzygium Jambos Leaf Extract, Iron Oxides Ci 77491, Tocopherol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.