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ISDIN vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

ISDIN and Sesderma are Spanish skincare brands that offer thoughtfully balanced and meticulously engineered formulas for daily care. The first brand is known for elegant moisturizers, advanced sunscreens, restorative serums, and targeted eye products that suit dry skin and sensitive skin best with reliable daily support. The second brand is beloved for advanced serums that suit sensitive, hyperpigmented, and aging skin types best. While both cater to sensitive concerns, they differ through distinct standout offerings such as Fusion Water, Eryfotona Actinica, and K-Ox Eyes from the older house, and Azelac RU Serum from the latter.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular ISDIN and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular ISDIN vs Sesderma products

Questions and answers

ISDIN or Sesderma: which is better?

ISDIN offers a much wider range of products covering various skin types and concerns, whereas Sesderma only features a single serum on this page. Lovi rates ISDIN as a Superior fit for dry, sensitive, and mature skin types.

What is the difference between ISDIN and Sesderma?

ISDIN offers a broad selection of products on the page with superior and high Lovi fits for dry, sensitive, and mature skin, while Sesderma is represented by only one product, Azelac RU Serum. ISDIN reviewers frequently praise its ultralight and makeup-friendly sunscreens despite a high price point.

Which is more affordable, ISDIN or Sesderma?

The provided page facts do not mention the prices of Sesderma products, but reviewers often mention a high price point for the products on this page from ISDIN.

Which causes fewer breakouts, ISDIN or Sesderma?

ISDIN offers several products on this page with a High fit for acne-prone skin, such as Fusion Water and Flavo-C Serum, while Sesderma provides Azelac RU Serum, which also has a High fit for acne-prone skin.

Between ISDIN and Sesderma, which brand was founded earlier and in what year?

ISDIN was founded earlier, in 1975, while Sesderma was founded in 1989.

How many total products are listed for ISDIN compared to Sesderma on this page?

ISDIN has a total of 8 products listed on this page, whereas Sesderma has only 1 product.

Which brand has products that achieve a Superior Lovi fit level for mature skin?

ISDIN has products on this page that achieve a Superior Lovi fit level for mature skin, specifically Eryfotona Actinica.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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