🇪🇸Spain

ISDIN vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

ISDIN and Sesderma are esteemed Spanish skincare brands known for their meticulously engineered formulas and expert care. The first brand offers thoughtful moisturizers, advanced sunscreens, targeted serums, and soothing eye products, while the latter is beloved for its advanced serums. Both options suit sensitive and mature or aging skin best, though the second brand is also tailored for hyperpigmented complexions. Ultimately, the two brands differ in their specific offerings, with the first providing specialized sun and eye solutions and the second focusing on botanical extracts and active compounds for radiant texture.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular ISDIN and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular ISDIN vs Sesderma products

Questions and answers

ISDIN or Sesderma: which is better?

ISDIN is the better choice on this page because it offers a much wider variety of products across multiple skincare categories, whereas Sesderma only features a single serum. Reviewers also frequently praise ISDIN for its ultralight and skin-friendly sunscreens.

What is the difference between ISDIN and Sesderma?

ISDIN offers eight products on this page featuring ultralight sunscreens and lightweight moisturizers with fit levels ranging up to Superior for sensitive and dry skin, while Sesderma is represented by a single serum that helps with dark spots and acne-prone skin at a High fit level.

Which is more affordable, ISDIN or Sesderma?

Reviews note that ISDIN has a high price point, while affordability details for Sesderma are not mentioned on this page.

Which causes fewer breakouts, ISDIN or Sesderma?

ISDIN has a wider range of products on this page with High fits for acne-prone skin, such as Eryfotona Actinica, Fusion Water, and Flavo-C Serum, while Sesderma offers Azelac RU Serum which also has a High fit for acne-prone skin.

When was ISDIN founded compared to Sesderma?

ISDIN was founded in 1975 in Spain, whereas Sesderma was founded later in 1989.

Which ISDIN sunscreen has a Superior fit level for dry sensitive skin?

Both Eryfotona Actinica and Fusion Water sunscreens have a Superior fit level for dry sensitive skin.

How many ISDIN products on the page list no fragrance?

Three ISDIN products on the products on this page list no fragrance.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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