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ISDIN vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

ISDIN and Sesderma are distinguished Spanish skincare brands founded in 1975 and 1989, respectively. The first brand is celebrated for its sophisticated moisturizers, advanced sunscreens, targeted serums, and soothing eye products, while Sesderma is beloved for its advanced serums and meticulously engineered formulas. Both labels suit sensitive skin best, with ISDIN additionally serving oily, acne-prone skin, and the latter brand catering to hyperpigmented and aging skin types. They differ primarily in their exact product range and specific target concerns, offering reliable daily protection and radiance through their unique, gentle compositions.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular ISDIN and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular ISDIN vs Sesderma products

Questions and answers

ISDIN or Sesderma: which is better?

ISDIN offers a much wider range of products on this page across multiple categories like sunscreens and serums, while Sesderma is represented by just a single serum.

What is the difference between ISDIN and Sesderma?

ISDIN offers a much wider selection of skincare products on this page across multiple categories like sunscreens and serums, whereas Sesderma is represented by just one serum.

Which is more affordable, ISDIN or Sesderma?

When it comes to affordability, reviewers on the page often mention that ISDIN has a high price point, while pricing details for Sesderma's products on this page are not highlighted.

Which causes fewer breakouts, ISDIN or Sesderma?

ISDIN offers multiple products on this page with a High Lovi fit for acne-prone skin, such as Eryfotona Actinica, Fusion Water, and Flavo-C Serum, while Sesderma has Azelac RU Serum at High fit.

How does the founding year and ownership compare between ISDIN and Sesderma?

ISDIN was founded in 1975 in Spain and is owned by Puig, whereas Sesderma was founded in 1989 in Spain and is owned by Grupo Sesderma since 2026.

Which brand offers more fragrance-free options among their listed products?

ISDIN offers more fragrance-free options among the products on this page, with 3 out of 8 listing no fragrance, whereas Sesderma lists fragrance in all of its products.

How do the Lovi fit levels for acne-prone skin compare between ISDIN's Azelac RU alternative equivalents and Sesderma's Azelac RU Serum?

For acne-prone skin, Lovi rates ISDIN's Retinal Intense Serum as High and Azelac RU Serum by Sesderma as High, while ISDIN's Azelac RU alternative equivalents are not available on this page.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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