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ISDIN vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

ISDIN and Sesderma are Spanish skincare brands that offer thoughtfully balanced and meticulously engineered formulas for daily care. The first brand is known for elegant moisturizers, advanced sunscreens, restorative serums, and targeted eye products that suit dry skin and sensitive skin best with reliable daily support. The second brand is beloved for advanced serums that suit sensitive, hyperpigmented, and aging skin types best. While both cater to sensitive concerns, they differ through distinct standout offerings such as Fusion Water, Eryfotona Actinica, and K-Ox Eyes from the older house, and Azelac RU Serum from the latter.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular ISDIN and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular ISDIN vs Sesderma products

Questions and answers

ISDIN or Sesderma: which is better?

ISDIN is a better fit than Sesderma because the products on this page cover many more skin types and concerns, whereas Sesderma only features one serum. Reviewers also like that ISDIN offers ultralight, skin-friendly sunscreens.

What is the difference between ISDIN and Sesderma?

ISDIN offers a broad selection of eight products on this page spanning sunscreens, moisturizers, and serums, whereas Sesderma is represented by just one serum. Reviewers frequently praise ISDIN for its ultralight and makeup-friendly sunscreens, though some note a high price point.

Which is more affordable, ISDIN or Sesderma?

Reviewers often mention that ISDIN has a high price point, while affordability details for Sesderma are not noted on this page.

Which causes fewer breakouts, ISDIN or Sesderma?

ISDIN has a wider range of products on this page with High fit levels for acne-prone skin, such as Eryfotona Actinica and Fusion Water, whereas Sesderma offers Azelac RU Serum which also rates High for acne-prone skin.

Which brand has been on the market longer, ISDIN or Sesderma?

ISDIN has been on the market longer, having been founded in Spain in 1975, whereas Sesderma was founded in 1989.

Do both ISDIN and Sesderma offer products containing fragrance?

Yes, both ISDIN and Sesderma offer products containing fragrance. Reviewers note that strong fragrance is sometimes found in ISDIN products, and the single Sesderma product on this page also lists fragrance.

Which ISDIN products achieve a Superior fit level for dry sensitive skin?

For dry sensitive skin, the products on this page by ISDIN that achieve a Superior fit level are Eryfotona Actinica and Fusion Water.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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