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ISDIN vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

ISDIN and Sesderma are esteemed Spanish skincare brands known for crafting advanced sunscreens, serums, moisturizers, and eye products with reliable ingredients. The former is celebrated for gentle formulas featuring key components that best suit sensitive and acne-prone skin, while the latter utilizes meticulously engineered botanical extracts and active compounds tailored for sensitive, hyperpigmented, and aging skin. While both companies offer standout solutions like the Fusion Water and the Azelac RU Serum, they differ in their foundational approaches, with ISDIN focusing on barrier-respecting daily care and its counterpart specializing in targeted textural refinement.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular ISDIN and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular ISDIN vs Sesderma products

Questions and answers

ISDIN or Sesderma: which is better?

ISDIN is the better option on this page because it offers a much wider variety of products with Superior and High Lovi fit levels for sensitive, acne-prone, and dry skin, whereas Sesderma only features one product.

What is the difference between ISDIN and Sesderma?

ISDIN offers a broad selection of sunscreens, moisturizers, and serums on this page, while Sesderma is represented by just one serum, Azelac RU Serum. Lovi rates ISDIN with Superior fits for specific products like Eryfotona Actinica on mature and sensitive skin, whereas Sesderma's serum reaches a High fit for acne-prone skin and skin with dark spots.

Which is more affordable, ISDIN or Sesderma?

When it comes to affordability, price is less frequently highlighted for Sesderma on this page, while ISDIN is often noted for having a high price point.

Which causes fewer breakouts, ISDIN or Sesderma?

For acne-prone skin, the products on this page by ISDIN have a High fit level, while Sesderma has an Average fit level for the same skin type.

How do the founding years and corporate ownership of ISDIN and Sesderma compare?

ISDIN was founded in Spain in 1975 and is owned by Puig, while Sesderma was founded in Spain in 1989 and is owned by Grupo Sesderma since 2026.

Which brand offers more products with no fragrance, ISDIN or Sesderma?

ISDIN offers more products with no fragrance on this page, with 3 out of 8 products listing no fragrance, compared to 0 out of 1 for Sesderma.

How does the Lovi fit level for Azelac RU Serum by Sesderma compare to ISDIN serums for dry skin?

Azelac RU Serum by Sesderma has a Low Lovi fit level for dry skin, whereas the ISDIN serums on this page range from Average to High fit levels for dry skin.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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