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ISDIN vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

ISDIN and Sesderma are distinguished Spanish skincare brands founded in 1975 and 1989, respectively. The former is celebrated for sophisticated moisturizers, advanced sunscreens, targeted serums, and soothing eye products that suit dry and combination skin, featuring standout formulas like Fusion Water, Eryfotona Actinica, and K-Ox Eyes. Meanwhile, the latter is known for advanced serums powered by botanical extracts and active compounds designed to refine texture and promote radiance. While both utilize meticulously engineered formulas, the first brand serves dry and combination skin best, whereas the second brand excels for sensitive, hyperpigmented, and aging skin with standout options such as Azelac RU Serum.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular ISDIN and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular ISDIN vs Sesderma products

Questions and answers

ISDIN or Sesderma: which is better?

ISDIN offers a much wider range of products on this page, with superior fits for sunscreens across multiple skin types, whereas Sesderma is represented by just one serum.

What is the difference between ISDIN and Sesderma?

ISDIN offers a broad selection of eight sunscreen, moisturizer, serum, and eye products on this page that generally fit dry, combination, and acne-prone skin well, whereas Sesderma is represented by only one serum.

Which is more affordable, ISDIN or Sesderma?

Reviewers frequently note that ISDIN has a high price point, while affordability details are not highlighted for Sesderma on this page.

Which causes fewer breakouts, ISDIN or Sesderma?

Both ISDIN and Sesderma offer products with High Lovi fit levels for acne-prone skin, meaning the products on this page are unlikely to cause breakouts.

Between ISDIN and Sesderma, which brand was founded earlier?

ISDIN was founded earlier in 1975, while Sesderma was founded in 1989.

How many products from ISDIN listed on the page do not contain fragrance?

Three products from ISDIN listed on this page list no fragrance. The products on this page feature a high price point according to reviewers.

What are the morning and evening steps in the example ISDIN routine for dry skin?

The example ISDIN routine for dry skin has a morning step of cleanser, hydrating toner, moisturizer, and SPF, and an evening step of pre-cleanser, cleanser, serum or treatment, and moisturizer. It also includes a weekly nourishing mask in the evening.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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