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CeraVe vs Sesderma

CeraVe and Sesderma are trusted skincare brands that offer reliable daily routines and advanced treatments, respectively. The American brand, founded in 2005, is known for dependable moisturizers, gentle cleansers, targeted serums, and protective sunscreens enriched with hyaluronic acid and glycerin, suiting mature and dry skin best. Meanwhile, the Spanish brand, founded in 1989, is beloved for advanced serums and meticulously engineered formulas that suit sensitive, hyperpigmented, and aging skin. While both deliver proven results through active compounds and botanical extracts, the former relies on barrier-supporting ingredients like glycerin, whereas the latter specializes in synergistic treatments like the Azelac RU Serum.

CeraVe is an American skincare brand founded in 2005 and owned by L'Oréal since 2017.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular CeraVe and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Questions and answers

CeraVe or Sesderma: which is better?

CeraVe is the better choice for most shoppers on this page, offering a wide range of fragrance-free cleansers, moisturizers, and serums that fit dry, mature, and acne-prone skin well. Sesderma features just one serum here, which contains fragrance.

What is the difference between CeraVe and Sesderma?

CeraVe offers a broad range of fragrance-free products on this page featuring ingredients like ceramides and hyaluronic acid that help hydrate and repair the skin barrier. In contrast, Sesderma features a more limited selection on this page, such as the Azelac RU Serum, which includes fragrance.

Journal of Pharmacy & Pharmaceutical Sciences, 2015

Which is more affordable, CeraVe or Sesderma?

The products on this page do not provide pricing information to compare affordability between CeraVe and Sesderma.

Which causes fewer breakouts, CeraVe or Sesderma?

CeraVe is unlikely to cause breakouts because the products on this page help maintain a gentle balance, though reviewers note that occasional breakouts can sometimes happen.

How do the founding years and countries of origin compare between CeraVe and Sesderma?

CeraVe was founded in the United States in 2005, whereas Sesderma was founded in Spain in 1989.

Which brand offers a larger product selection and a wider variety of skincare categories on this page?

CeraVe offers a much larger product selection and a wider variety of skincare categories on this page than Sesderma. The products on this page for CeraVe cover diverse categories such as moisturizers, cleansers, serums, sunscreens, and makeup removers, whereas Sesderma currently lists only a single serum.

Do both CeraVe and Sesderma products contain fragrance according to their ingredient lists?

The products on this page for CeraVe list no fragrance in their ingredients, whereas the Azelac RU Serum by Sesderma includes fragrance.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.