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ISDIN vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

ISDIN and Sesderma are Spanish skincare brands offering thoughtful moisturizers, sunscreens, serums, and eye products driven by sophisticated and meticulously engineered formulas. The former is beloved for its reliable, gentle efficacy and suits acne-prone and combination skin best with standout products like Fusion Water, Eryfotona Actinica, and K-Ox Eyes. Meanwhile, the latter is cherished for advanced serums that suit sensitive, hyperpigmented, and aging skin with standout options like the Azelac RU Serum. They differ primarily in their active compounds and targeted skin types, with both utilizing botanical extracts and active blends to nurture a radiant complexion.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular ISDIN and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular ISDIN vs Sesderma products

Questions and answers

ISDIN or Sesderma: which is better?

ISDIN is the better choice on this page because it offers a much wider variety of products with high Lovi fit levels across skin types, such as its ultralight sunscreens and serums. Sesderma features only a single serum on this page, which limits your routine options.

What is the difference between ISDIN and Sesderma?

ISDIN offers a broad selection of sunscreens, moisturizers, serums, and eye products on this page, whereas Sesderma is represented by only one serum. ISDIN has a Lovi fit level of High for acne-prone, combination, and sensitive skin.

Which is more affordable, ISDIN or Sesderma?

Sesderma is not marked by a high price point on this page, whereas reviewers often note that the products on this page from ISDIN have a high price point.

Which causes fewer breakouts, ISDIN or Sesderma?

ISDIN offers multiple products with a High Lovi fit for acne-prone skin, such as Fusion Water and Retinal Intense Serum, whereas Sesderma has only one product on this page with a High fit for acne-prone skin. Reviewers often mention that the products on this page by ISDIN are ultralight.

How does the founding year and ownership compare between ISDIN and Sesderma?

ISDIN was founded earlier in 1975 in Spain and is owned by Puig, whereas Sesderma was founded in 1989 in Spain and is owned by Grupo Sesderma.

Which brand offers more fragrance-free product options on this page?

ISDIN offers more fragrance-free product options on this page, with 3 out of 8 products listing no fragrance compared to none for Sesderma.

How do the Lovi fit levels for acne-prone skin compare between ISDIN's Azelac alternative products and Sesderma's Azelac RU Serum?

ISDIN offers products like Eryfotona Actinica and Fusion Water with a High Lovi fit level for acne-prone skin, whereas Sesderma's Azelac RU Serum also achieves a High Lovi fit for acne-prone skin.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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