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ISDIN vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

ISDIN and Sesderma are Spanish skincare brands that offer thoughtfully balanced and meticulously engineered formulas for daily care. The first brand is known for elegant moisturizers, advanced sunscreens, restorative serums, and targeted eye products that suit dry skin and sensitive skin best with reliable daily support. The second brand is beloved for advanced serums that suit sensitive, hyperpigmented, and aging skin types best. While both cater to sensitive concerns, they differ through distinct standout offerings such as Fusion Water, Eryfotona Actinica, and K-Ox Eyes from the older house, and Azelac RU Serum from the latter.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular ISDIN and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular ISDIN vs Sesderma products

Questions and answers

ISDIN or Sesderma: which is better?

ISDIN is the better fit for most shoppers on this page because it offers a much wider range of products that achieve High or Superior Lovi fit levels across multiple skin types. Meanwhile, the single Sesderma product on this page only reaches High or Average fits for a few specific concerns like dark spots and acne-prone skin.

What is the difference between ISDIN and Sesderma?

ISDIN offers a broad selection of products on this page covering sun care, serums, and moisturizers with high fit levels for dry, sensitive, and mature skin, whereas Sesderma is represented by a single serum focused on dark spots and acne-prone skin.

Which is more affordable, ISDIN or Sesderma?

Reviewers often note that the products on this page from ISDIN have a high price point. The page facts do not mention pricing or affordability information for Sesderma.

Which causes fewer breakouts, ISDIN or Sesderma?

ISDIN has a High fit for acne-prone skin with multiple products on this page like Eryfotona Actinica, whereas Sesderma offers Azelac RU Serum which has a High fit for acne-prone skin.

Which brand has been around longer and where were they founded?

ISDIN has been around longer, having been founded in Spain in 1975, while Sesderma was founded in Spain in 1989.

How many ISDIN products on the page list no fragrance compared to Sesderma?

ISDIN has 3 products on this page that list no fragrance, whereas Sesderma has none since its only product contains fragrance.

What do reviewers say are the pros and cons of ISDIN products?

Reviewers report that the pros of the products on this page from ISDIN include ultralight, lightweight, makeup-friendly, and skin-friendly sunscreens, while the cons are a high price point and strong fragrance.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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