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ISDIN vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

ISDIN and Sesderma are esteemed Spanish skincare brands known for crafting advanced sunscreens, serums, moisturizers, and eye products with reliable ingredients. The former is celebrated for gentle formulas featuring key components that best suit sensitive and acne-prone skin, while the latter utilizes meticulously engineered botanical extracts and active compounds tailored for sensitive, hyperpigmented, and aging skin. While both companies offer standout solutions like the Fusion Water and the Azelac RU Serum, they differ in their foundational approaches, with ISDIN focusing on barrier-respecting daily care and its counterpart specializing in targeted textural refinement.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular ISDIN and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular ISDIN vs Sesderma products

Questions and answers

ISDIN or Sesderma: which is better?

ISDIN offers a wider variety of products on this page across multiple categories like sunscreens and serums, while Sesderma is represented by a single serum.

What is the difference between ISDIN and Sesderma?

ISDIN is a Spanish brand founded in 1975 with a wide range of popular sunscreens and serums, while Sesderma is a Spanish brand founded in 1989 represented on this page by just one serum, Azelac RU Serum. Lovi rates ISDIN as a Superior fit for sensitive and acne-prone skin, whereas Sesderma reaches a High fit for acne-prone skin and skin with dark spots.

Which is more affordable, ISDIN or Sesderma?

Reviews often note that ISDIN has a high price point, but the provided page facts do not contain pricing information to compare its affordability directly with Sesderma.

Which causes fewer breakouts, ISDIN or Sesderma?

ISDIN offers a range of products that Lovi rates as a High fit for acne-prone skin, including Eryfotona Actinica, Fusion Water, K-Ox Eyes, Hyaluronic Concentrate, Flavo-C Serum, and Retinal Intense Serum. Sesderma includes Azelac RU Serum, which Lovi rates as a High fit for acne-prone skin.

How does the founding year and ownership differ between ISDIN and Sesderma?

ISDIN was founded in 1975 in Spain and is owned by Puig, whereas Sesderma was founded in 1989 in Spain and is owned by Grupo Sesderma since 2026.

Which brand offers more fragrance-free products based on the available page data?

ISDIN offers more fragrance-free products on this page, with three out of eight products listing no fragrance, compared to Sesderma, which has none.

Which skin types do ISDIN's brand-focused routines fit best?

According to the brand-focused routines on this page, ISDIN fits sensitive skin, acne-prone skin, and oily skin best.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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