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ISDIN vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

ISDIN and Sesderma are Spanish skincare brands that offer thoughtfully balanced and meticulously engineered formulas for daily care. The first brand is known for elegant moisturizers, advanced sunscreens, restorative serums, and targeted eye products that suit dry skin and sensitive skin best with reliable daily support. The second brand is beloved for advanced serums that suit sensitive, hyperpigmented, and aging skin types best. While both cater to sensitive concerns, they differ through distinct standout offerings such as Fusion Water, Eryfotona Actinica, and K-Ox Eyes from the older house, and Azelac RU Serum from the latter.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular ISDIN and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular ISDIN vs Sesderma products

Questions and answers

ISDIN or Sesderma: which is better?

ISDIN offers a much wider range of products on this page, achieving a Superior fit for dry and sensitive skin, whereas Sesderma only features one product.

What is the difference between ISDIN and Sesderma?

ISDIN offers a broad selection of eight products on this page spanning sunscreens, serums, and moisturizers with a best fit for dry, sensitive, and mature skin, whereas Sesderma is represented by a single serum, Azelac RU Serum, which is designed for dark spots and acne-prone skin.

Which is more affordable, ISDIN or Sesderma?

The provided page facts do not mention the prices of Sesderma products, but they note that ISDIN has a high price point.

Which causes fewer breakouts, ISDIN or Sesderma?

For acne-prone skin, the products on this page by ISDIN have a High fit with Eryfotona Actinica, Fusion Water, Flavo-C Serum, and Retinal Intense Serum, while Sesderma offers Azelac RU Serum at a High fit. Both brands help address breakouts, though ISDIN provides more options.

Between ISDIN and Sesderma, which brand was founded earlier?

ISDIN was founded earlier, in 1975 in Spain, while Sesderma was founded in 1989.

How does the Lovi fit level for dry skin compare between ISDIN's Eryfotona Actinica and Sesderma's Azelac RU Serum?

ISDIN's Eryfotona Actinica has a Superior Lovi fit level for dry skin, whereas Sesderma's Azelac RU Serum has a Low fit level for that skin type.

Which products from ISDIN and Sesderma contain fragrance according to the page?

From ISDIN, Fusion Water, K-Ox Eyes, Hyaluronic Concentrate, Uradin Lotion 10, and Retinal Intense Serum contain fragrance, while Azelac RU Serum is the only product listed from Sesderma and it also contains fragrance.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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