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ISDIN vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

ISDIN and Sesderma are Spanish skincare brands that offer thoughtfully balanced and meticulously engineered formulas for daily care. The first brand is known for elegant moisturizers, advanced sunscreens, restorative serums, and targeted eye products that suit dry skin and sensitive skin best with reliable daily support. The second brand is beloved for advanced serums that suit sensitive, hyperpigmented, and aging skin types best. While both cater to sensitive concerns, they differ through distinct standout offerings such as Fusion Water, Eryfotona Actinica, and K-Ox Eyes from the older house, and Azelac RU Serum from the latter.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular ISDIN and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular ISDIN vs Sesderma products

Questions and answers

ISDIN or Sesderma: which is better?

ISDIN is the better choice for most shoppers because the products on this page cover a much wider variety of skin types and concerns than Sesderma. Reviewers also frequently praise ISDIN for its ultralight and skin-friendly sunscreens.

What is the difference between ISDIN and Sesderma?

ISDIN offers a broad range of eight products on this page with various Lovi fit levels for dry, sensitive, and acne-prone skin, whereas Sesderma is represented by only a single product, Azelac RU Serum. Reviewers note that ISDIN features ultralight and makeup-friendly sunscreens, though many of its items contain added fragrance.

Which is more affordable, ISDIN or Sesderma?

When it comes to affordability, reviewers often mention that the products on this page from ISDIN have a high price point. The provided page facts do not mention pricing information for Sesderma.

Which causes fewer breakouts, ISDIN or Sesderma?

For acne-prone skin, both brands offer products on this page with a High Lovi fit level, such as Eryfotona Actinica from ISDIN and Azelac RU Serum from Sesderma. Reviewers frequently mention that the products on this page by ISDIN are lightweight moisturizers and ultralight sunscreens, which helps prevent clogged pores.

Between ISDIN and Sesderma, which brand was founded earlier?

ISDIN was founded earlier, in 1975 in Spain, while Sesderma was founded in 1989.

How do the fragrance options differ between ISDIN and Sesderma products listed on the page?

ISDIN has 3 out of 8 products on this page that list no fragrance, while the remaining 5 products include fragrance. In contrast, the only Sesderma product listed on this page includes fragrance.

Which brand has more sunscreen options reviewed on the page?

ISDIN has more sunscreen options reviewed on the products on this page, offering choices like Eryfotona Actinica and Fusion Water. Sesderma does not feature any sunscreens in its lineup.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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