Shiseido Extra Rich Cleansing Milk for dry sensitive skin

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Questions and answers

What the research says

• A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers.

  Molecules, 2024

• L-ascorbic acid and betaine-based therapeutic deep eutectic system significantly enhanced transdermal delivery through porcine skin compared to ascorbic acid alone or physical mixture, and reduced aging markers while inducing an even skin tone in humans.

  Pharmaceutics, 2024

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Bacterial cellulose wound dressing containing silk sericin and PHMB improved wound quality and reduced pain compared to Bactigras in patients with split-thickness skin graft donor-site wounds.

  Archives of Dermatological Research, 2018

• A bacterial nanocellulose wound dressing incorporating polyhexamethylene biguanide and sericin showed no skin irritation in healthy volunteers and significantly promoted wound healing with lower wound size and higher collagen formation in full-thickness rat wounds compared to controls.

  Archives of Dermatological Research, 2016

• Topical application of sericin gels increased skin intrinsic moisturization, hydroxyproline content, and epidermal hydration while decreasing transepidermal water loss and skin impedance in healthy human volunteers.

  Journal of Cosmetic Dermatology, 2005

• Citrus junos callus extract decreased melanin content in melanocytes 1.85-fold compared with arbutin and promoted the proliferation of and procollagen synthesis by human fibroblasts by 154% and 176% at 500 μg/mL.

  Molecules, 2017

• Yuja-peel fractions (ethyl acetate, hexane, and butanol) inhibited MMP expression, induced moisturizing factors filaggrin and serine palmitoyltransferase, and decreased melanin content in UVB-irradiated HaCaT, HDF, and α-MSH-treated B16F10 cells.

  Antioxidants, 2022

• Upcycled low-molecular-weight anionic peptides from Citrus junos seeds protected UVR-irradiated keratinocytes and reconstructed skin tissue by scavenging reactive oxygen species, reducing paracrine cytokines, inhibiting melanin synthesis and TRP-2 expression, and increasing filaggrin, laminin-5, and type I collagen expression.

  International Journal of Molecular Sciences, 2024

Why other cleansers fit dry sensitive skin better

• Transgenic cucumber expressing poly-γ-glutamic acid synthesis genes increased water content by 6-14%, reduced water loss by 11-12%, decreased facial wrinkles and roughness by 19.58% and 24.97%, decreased skin melanin by 5.27%, and improved facial elasticity in human skin and zebrafish compared to controls.

  International Journal of Biological Macromolecules, 2024

Ingredients

Water, Sodium Methyl Cocoyl Taurate, Cocamidopropyl Betaine, Peg-2 Laurate, Glycol Distearate, Propylene Glycol Laurate, Glycerin, Dipropylene Glycol, Polyquaternium-10, Phenoxyethanol, Sodium Benzoate, Parfum, Citric Acid, Rice Germ Oil, Disodium Edta, Linalool, Geraniol, Citronellol, Alcohol, Betaine, Ci 15985, Sodium Acetylated Hyaluronate, Citrus Junos Seed Extract, Tocopherol, Red 33 Ci 17200, Hydrolyzed Silk

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.