Shiseido Vital Perfection Intensive WrinkleSpot Treatment for sensitive skin

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Questions and answers

What the research says

• Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.

  The British Journal of Dermatology, 2019

• Transethosome-based delivery systems loaded with retinyl acetate enhanced stability, bioavailability, and skin penetration while minimizing irritation, with DOPC/DPPC/Chol systems and SoyPC/Chol systems containing oleic acid or palmitic acid demonstrating superior therapeutic efficacy and wound healing enhancement.

  Scientific Reports, 2025

• An Angelica sinensis extract containing 1% ligustilide demonstrated anti-inflammatory, antioxidant, anti-senescence, matrix-supportive, and antimicrobial effects in human keratinocytes and dermal fibroblasts.

  Frontiers in Pharmacology, 2026

• Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.

  International Journal of Cosmetic Science, 2017

• Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.

  Journal of Controlled Release, 2018

• Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle.

  Archives of Dermatological Research, 2017

• Potassium 4-methoxysalicylate (4MSK) suppresses melanin content, promotes keratinocyte differentiation, increases skin lightness in pigmented and non-pigmented cheek areas, and reduces the desquamation area ratio.

  Journal of Cosmetic Dermatology, 2025

• An in situ hydrated ionic liquid-like state strategy using potassium 4-methoxysalicylate and arginine hydrochloride increased human skin permeation to 237% of control and reduced melanin content by 33% in a reconstructed human epidermis model.

  International Journal of Pharmaceutics, 2026

• Plant extracts from Gomphrena globasa L., Clitoria ternatea L., Carthamus tinctorius L., Punica granatum L., and Papaver rhoeas L. demonstrated no cytotoxicity, high antioxidant potential, strong collagenase inhibition, moderate elastase inhibition, effective skin hydration, and varying suitability as stable cosmetic dyes when tested on keratinocyte and fibroblast cell lines and incorporated into face cream formulations.

  Molecules, 2021

• Water extracts of Papaver rhoeas L., Punica granatum L., Clitoria ternatea L., Carthamus tinctorius L., and Gomphrena globosa L. showed no cytotoxicity on skin cells while exhibiting antioxidant, anti-inflammatory, and enzyme-inhibiting properties, with P. rhoeas, C. ternatea, and C. tinctorius demonstrating strong permanent coloring ability in cosmetic products.

  Molecules, 2022

• Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism.

  Evidence-based Complementary and Alternative Medicine, 2015

• Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo.

  Experimental Dermatology, 2015

• Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.

  Advanced Science, 2025

Ingredients

Water, Pentaerythrityl Tetraethylhexanoate, Dipropylene Glycol, Hydrogenated Polydecene, Glycerin, Betaine, Behenyl Alcohol, Dimethicone, Potassium Methoxysalicylate, Petrolatum, Hydrogenated Palm Oil, Stearyl Alcohol, Maltitol, Beheneth-20, Palm Kernel Oil, Phenoxyethanol, Butylene Glycol, Palm Oil, Carnauba Wax Cera Copernicia Cerifera Cire De Carnauba Wax Cera, Hydrogenated Polyisobutene, Polyvinyl Alcohol, Microcrystalline Wax Cera Microcristallina Cire Microcristalline Wax Cera, Parfum, Carbomer, Tocopheryl Acetate, Rosa Damascena Flower Water, Xanthan Gum, Bht, Retinol, Polysorbate 20, Alcohol, Caffeine, Potassium Hydroxide, Lavandula Angustifolia Oil Lavender Oil, Trisodium Edta, Ppg-3 Dipivalate, Limonene, Tocopherol, Hexyl Cinnamal, Linalool, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Citronellol, Angelica Acutiloba Root Extract, Angelica Keiskei Stem Extract Leaf, Olea Europaea Leaf Extract Olive Leaf Extract, Sanguisorba Officinalis Root Extract, Lamium Album Stem Extract Flower Leaf, Camellia Sinensis Leaf Extract, Inositol, Carthamus Tinctorius Flower Extract, Pinus Sylvestris Cone Extract, Ziziphus Jujuba Fruit Extract, Retinyl Acetate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Cellulose, Beta-Carotene, Cinnamomum Cassia Bark Extract, Citric Acid, Bupleurum Falcatum Root Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.