The Ordinary Multi-Peptide + HA Serum for oily acne-prone skin
Multi-Peptides
Sodium Hyaluronate
Lactococcus Lysate Ferment
Acetyl Hexapeptide-8
Palmitoyl Tripeptide-1
Average
- SuperiorOily Skin Fit
- HighEffectiveness
- ExcellentSafety
Works for oily acne-prone skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your acne, blemishes, and breakouts, and oiliness on your oily skin due to the presence of peptides like Acetyl Hexapeptide-8 and Pentapeptide-18 in concentrations that support skin barrier function and hydration.
- Provides excellent plumping and firming due to multiple peptides and hydrating ingredients such as Sodium Hyaluronate Crosspolymer, which are well-suited for your oily skin.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of harsh ingredients and the presence of soothing ingredients like Allantoin and Glycerin.
How to apply
- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
People Say
★4.4Overall rating based on 2.5k+ reviewsBased on a very large amount of data, users with dry, mature, or dehydrated skin frequently praise this serum for its ability to plump the skin and smooth texture, often noting a reduction in fine dehydration lines. While many appreciate it as an affordable "all-in-one" anti-aging solution, a minority of users report breakouts or a lack of visible results regarding deeper wrinkles.
Highlights
Deeply hydrates Mostly Mentioned
- “Surprisingly hydrated my skin very well in the dry mountain air.”
- “My skin feels more hydrated, smooth, and plump.”
- “It’s so hydrating for the skin.”
- “Left my skin feeling very moisturizing.”
Great value Often Mentioned
- “Good quality and good price.”
- “Buying the 60ml is better value... good value for money.”
- “Proof you don't need to spend a fortune for good science.”
- “Affordable and will last you months.”
Smooths texture Often Mentioned
- “It really improved the texture of my skin.”
- “Left my skin feeling so smooth.”
- “Noticeably smoother skin in 8 weeks.”
- “Improves skin smoothness and targets multiple signs of aging.”
Plumps and firms Sometimes Noted
- “Makes my skin feel so firm after use.”
- “Experience firmer, plumper, and more resilient skin.”
- “Improves the feel of skin elasticity.”
- “Skin feels tighter after.”
Reduces fine lines Sometimes Noted
- “I notice less of crows feet after.”
- “Fine lines around my eyes... look much less prominent.”
- “Targets dynamic lines and wrinkles.”
- “Helps significantly improve the appearance of crow's feet.”
Conflicts with actives Sometimes Noted
- “Avoid using direct acids, direct vitamin C... in the same routine.”
- “Can be complicated to use... peptides and Vitamin C don't play well.”
- “Hard to fit into my routine due to conflicts.”
- “Cannot use with my other acid toners.”
Unclear results Sometimes Noted
- “Didn't see exceptional results but good for a basic serum.”
- “Quite nice feeling but idk what it does honestly.”
- “Haven't noticed a huge difference in wrinkles yet.”
- “Good basic serum but don't expect miracles.”
Allergic reactions Rarely Noted
- “My eyes were swollen almost shut the morning after.”
- “Do not use if you have sensitive skin!!”
- “Caused a burning sensation immediately.”
- “Face turned red and itchy.”
Causes breakouts Rarely Noted
- “Some people say Buffet has made their skin break out.”
- “Worried about this product causing acne.”
- “Caused small bumps on my forehead.”
- “My skin broke out after a few days.”
Sources: lovi.care, theordinary.com, sephora.com, ulta.com, amazon.com, deciemchatroom.com, and more
Questions and answers
How well does The Ordinary Multi-Peptide + HA work for oily acne-prone skin?
The Ordinary Multi-Peptide + HA Serum works moderately well for oily acne-prone skin, offering good hydration and firmness without causing irritation. To better fit this skin type, a product of this type needs ingredients like niacinamide, propolis, or Vitamin C to control excess oil and address blemishes.
Which ingredients make this serum a good fit for oily acne-prone skin?
This serum is a good fit for oily acne-prone skin because it contains peptides like Acetyl Hexapeptide-8 and Pentapeptide-18, along with Sodium Hyaluronate, which support skin barrier function and hydration without irritation. To better fit this skin type, a product of this type needs effective ingredients like niacinamide, propolis, or Vitamin C to provide excellent benefits for acne and excess oil while promoting a healthy glow.
What do Peptides do for oily acne-prone skin?
Peptides help oily, acne-prone skin by targeting acne-causing bacteria and fighting inflammation with a favorable safety profile. These ingredients work directly to calm breakouts and support clearer skin.
What does Hyaluronic Acid do for oily acne-prone skin?
Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
The Journal of Investigative Dermatology, 2017Journal of Cosmetic Dermatology, 2022
Where does this serum go in a skincare routine for oily acne-prone skin?
This serum goes in the evening routine after cleansing and before moisturizing, though some serums may also be used in the morning or twice a day. An average fit for oily acne-prone skin means this product works, but this skin type typically benefits more from targeted blemish-fighting ingredients and oil-balancing actives.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to give your oily skin hydration, followed by the retinol once it absorbs. This routine is unlikely to cause irritation because the serum contains soothing ingredients like allantoin and glycerin.
How often should I use this serum?
You can use this serum in the evening as part of your routine. It is unlikely to irritate your oily skin because it lacks harsh ingredients and includes soothing components like allantoin and glycerin.
Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?
This serum is unlikely to cause breakouts or clog pores on oily acne-prone skin, as it has a very safe formula free of harsh ingredients. However, to truly clear up blemishes and control oil, oily skin needs targeted ingredients like salicylic acid and niacinamide.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020Orphanet Journal of Rare Diseases, 2020
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020SD-101 6% cream showed no statistically significant difference compared to vehicle in time to target wound closure or the proportion of patients achieving complete target wound closure within 3 months in patients with epidermolysis bullosa.
Orphanet Journal of Rare Diseases, 2020Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.
European Journal of Neurology, 2013Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.
Journal of Cosmetic Dermatology, 2015Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.
Journal of Cosmetic Dermatology, 2026Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.
International Journal of Cosmetic Science, 2026
Ingredients
Water, Glycerin, Lactococcus Lysate Ferment, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium Pca, Pca, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, Ppg-26-Buteth-26, Peg-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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