Shiseido Vital Perfection Uplifting and Firming Cream Enriched for skin with dark spots

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Questions and answers

What the research says

• Potassium 4-methoxysalicylate (4MSK) suppresses melanin content, promotes keratinocyte differentiation, increases skin lightness in pigmented and non-pigmented cheek areas, and reduces the desquamation area ratio.

  Journal of Cosmetic Dermatology, 2025

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical application of a vitamin C-squalene bioconjugate significantly increased epidermal thickness, type III collagen production, and glycosaminoglycans production in human skin explants compared to free vitamin C and vitamin C-palmitate.

  Scientific Reports, 2020

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant extracts from Gomphrena globasa L., Clitoria ternatea L., Carthamus tinctorius L., Punica granatum L., and Papaver rhoeas L. demonstrated no cytotoxicity, high antioxidant potential, strong collagenase inhibition, moderate elastase inhibition, effective skin hydration, and varying suitability as stable cosmetic dyes when tested on keratinocyte and fibroblast cell lines and incorporated into face cream formulations.

  Molecules, 2021

• Water extracts of Papaver rhoeas L., Punica granatum L., Clitoria ternatea L., Carthamus tinctorius L., and Gomphrena globosa L. showed no cytotoxicity on skin cells while exhibiting antioxidant, anti-inflammatory, and enzyme-inhibiting properties, with P. rhoeas, C. ternatea, and C. tinctorius demonstrating strong permanent coloring ability in cosmetic products.

  Molecules, 2022

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

• An Angelica sinensis extract containing 1% ligustilide demonstrated anti-inflammatory, antioxidant, anti-senescence, matrix-supportive, and antimicrobial effects in human keratinocytes and dermal fibroblasts.

  Frontiers in Pharmacology, 2026

• Screening of forty herb extracts using melan-a cells showed that hexane and dichloromethane extracts of Angelica sinensis, alongside compounds 4-ethylresorcinol, 4-ethylphenol, and 1-tetradecanol, exhibited strong hypopigmentary effects by attenuating melanin synthesis.

  Journal of Ethnopharmacology, 2010

• Hydroxypropyl-β-cyclodextrin-complexed Angelica sinensis essential oil-loaded microneedles demonstrated antibacterial activity against P. acnes, reduced acne lesion size and IL-1β levels, and suppressed 5α-reductase and FAS expression.

  Drug Delivery and Translational Research, 2026

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

Ingredients

Water, Butylene Glycol, Glycerin, Triethylhexanoin, Dimethicone, Alcohol, Propanediol, Phytosteryl Macadamiate, Ppg-3 Dipivalate, Glyceryl Stearate Se, Silica, Squalane, Hydrogenated Polydecene, Cetyl Alcohol, Peg-100 Stearate, Behenyl Alcohol, Peg Ppg-14 7 Dimethyl Ether, Potassium Methoxysalicylate, Butyrospermum Parkii Butter Shea Butter, Stearyl Alcohol, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Carnauba Wax Cera Copernicia Cerifera Cire De Carnauba Wax Cera, Phenoxyethanol, Hydrogenated Polyisobutene, Hydrogenated Palm Oil, Isohexadecane, Palm Kernel Oil, Palm Oil, Parfum, Polysorbate 80, Disodium Edta, Sorbitan Tristearate, Succinoglycan, Tocopheryl Acetate, Erythritol, Peg Ppg-17 4 Dimethyl Ether, Rosa Damascena Flower Water, Sodium Citrate, Sorbitan Oleate, Caffeine, Sodium Metaphosphate, Lavandula Angustifolia Oil Lavender Oil, Iron Oxides Ci 77492, Citric Acid, Limonene, Tocopherol, Hexyl Cinnamal, Linalool, Citronellol, Sodium Metabisulfite, Iron Oxides Ci 77491, Angelica Acutiloba Root Extract, Angelica Keiskei Stem Extract Leaf, Olea Europaea Leaf Extract Olive Leaf Extract, Lamium Album Stem Extract Flower Leaf, Cellulose, Camellia Sinensis Leaf Extract, Inositol, Carthamus Tinctorius Flower Extract, Ziziphus Jujuba Fruit Extract, Rosamarinus Officinalis Leaf Extract Rosemary Leaf Extract Rosmarinus Officinalis Leaf Extract, Hydrolyzed Silk, Bupleurum Falcatum Root Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.