Hyaluronic acid and wound healing
Sodium hyaluronate · Journal of Pharmacy & Pharmaceutical Sciences, 2015The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer
Niacinamide · The British Journal of Dermatology, 2002Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage
Sodium hyaluronate, Hyaluronic acid · Drug Delivery, 2017Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity
Ethanol · Journal of Occupational Medicine and Toxicology, 2008Topical menthol--a human model for cold pain by activation and sensitization of C nociceptors
Peppermint oil · Brain, 2004Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress
Camellia sinensis extract, Epigallocatechin gallate, Camellia sinensis, Camellia sinensis leaf extract extract, Polyphenols · Carcinogenesis, 2001Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation
Niacinamide · Antioxidants, 2021Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence
Curcuma longa root extract · Phytotherapy Research, 2016Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate
Alcohol · International Journal of Toxicology, 2001Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation
Lepidium sativum extract sprout · Proceedings of the National Academy of Sciences of the United States of America, 2007Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments
Hydrogenated rice bran oil, Rice bran oil, Water ep · Journal of Nanobiotechnology, 2011Cosmetic benefits of astaxanthin on humans subjects
Astaxanthin extract, Astaxanthin · Acta Biochimica Polonica, 2012Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
Sodium hyaluronate, Hyaluronic acid, Triple hyaluronic acid, Low molecular hyaluronic acid, Triple hyaluronic acid complex · Dermatologic Therapy, 2022Topical use of dexpanthenol in skin disorders
Panthenol, Vitamin b5, Vitamin b5 panthenol, Panthenol vitamin b5, Panthenol vb5 · American Journal of Clinical Dermatology, 2002The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review
Aloe barbadensis leaf juice, Aloe barbadensis, Aloe barbadensis leaf water, Aloe barbadensis extract · Iranian Journal of Medical Sciences, 2019Bifidobacterium longum lysate, a new ingredient for reactive skin
1 · Experimental Dermatology, 2010Caffeine's mechanisms of action and its cosmetic use
Caffeine · Skin Pharmacology and Physiology, 2013Cutaneous photoprotection from ultraviolet injury by green tea polyphenols
Camellia sinensis extract · Journal of the American Academy of Dermatology, 2001Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes
Epigallocatechin gallate, Camellia sinensis, Camellia sinensis leaf extract extract · The Journal of Investigative Dermatology, 2013A systematic review of Calendula officinalis extract for wound healing
Calendula officinalis flower extract · Wound Repair and Regeneration, 2019A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin
Liposomal vitamin complex vitanol · Journal of Cosmetic Dermatology, 2016Improvement of naturally aged skin with vitamin A (retinol)
Retinol, Pro-retinol a, Liposomal vitamin complex vitanol · Archives of Dermatology, 2007Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris
Squalane, Squalene · The Journal of Investigative Dermatology, 2006Regulatory effects of Lactobacillus plantarum-GMNL6 on human skin health by improving skin microbiome
Probiotics, Lactobacillus, Probiotics complex · International Journal of Medical Sciences, 2021Final report on the safety assessment of BHT(1)
Bht · International Journal of Toxicology, 2002Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo
Vitamin c derivatives, Sodium ascorbyl phosphate ascorbic acid, Ascorbic acid magnesium ascorbyl phosphate, Ascorbyl palmitate ascorbic acid · Experimental Dermatology, 2003Lactobacillus reuteri DSM 17938-A comparative study on the effect of probiotics and lysates on human skin
Probiotics · Experimental Dermatology, 2019Nicotinic acid/niacinamide and the skin
Niacin · Journal of Cosmetic Dermatology, 2004Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Ascorbic acid, Tocopherol, Tocopherol vitamin e, Vitamin e tocopherol · Journal of Cosmetic Dermatology, 2020A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation
Ferulic acid · Journal of the American Academy of Dermatology, 2008Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin
Quercetin · International Journal of Molecular Sciences, 2019Biological effects of rutin on skin aging
Rutin · International Journal of Molecular Medicine, 2016Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin
Ferulic acid · Journal of Cosmetic Dermatology, 2008The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study
Melaleuca alternifolia tree oil leaf, Melaleuca alternifolia tree leaf extract, Melaleuca alternifolia tree extract · Indian Journal of Dermatology, Venereology and Leprology, 2007Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics
Collagen, Water-soluble collagen, Collagen including hydrolyzed collagen atelocollagen · Dermatology Practical & Conceptual, 2022Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo
Retinol, Vitamin a · International Journal of Cosmetic Science, 2017Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin
Palmitoyl pentapeptide-4, Peptide complex · International Journal of Cosmetic Science, 2005Effects of menthol and cold on histamine-induced itch and skin reactions in man
Peppermint leaf extract, Menthol · Neuroscience Letters, 1995Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris
Phytosphingosine · International Journal of Cosmetic Science, 2007Production and characterization of cosmetic nanoemulsions containing Opuntia ficus-indica (L.) mill extract as moisturizing agent
Opuntia ficus-indica stem extract · Molecules, 2015Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care
Ubiquinone · BioFactors, 2008The Effect of Lactobacillus plantarum Extracellular Vesicles from Korean Women in Their 20s on Skin Aging
Probiotics, Probiotics complex · Current Issues in Molecular Biology, 2022Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica
Opuntia ficus-indica fruit extract, Opuntia ficus-indica stem extract, Cactus extract · BioMed Research International, 2015Lipid functions in skin: Differential effects of n-3 polyunsaturated fatty acids on cutaneous ceramides, in a human skin organ culture model
Fatty acids · Biochimica Et Biophysica Acta. Biomembranes, 2017Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
Retinol, Bakuchiol, Vitamin a, Liposomal vitamin complex vitanol · The British Journal of Dermatology, 2019Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo
Ascorbyl glucoside, Sodium ascorbyl phosphate ascorbic acid · Journal of Periodontology, 2009Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin
Scutellaria baicalensis root extract · Journal of Drugs in Dermatology, 2014The estimation of the traditionally used yarrow (Achillea millefolium L. Asteraceae) oil extracts with anti-inflamatory potential in topical application
Achillea millefolium oil · Journal of Ethnopharmacology, 2017Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
Panax ginseng extract, Panax ginseng root extract, Panax ginseng water root · Journal of Ginseng Research, 2017In vitro evaluation of Spirulina platensis extract incorporated skin cream with its wound healing and antioxidant activities
Spirulina platensis extract · Pharmaceutical Biology, 2017Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women
Glutathione, Acyl-glutathione · Clinical, Cosmetic and Investigational Dermatology, 2014Bog blueberry anthocyanins alleviate photoaging in ultraviolet-B irradiation-induced human dermal fibroblasts
Blueberry fruit extract · Molecular Nutrition & Food Research, 2009Lactate triggers KAT8-mediated LTBP1 lactylation at lysine 752 to promote skin rejuvenation by inducing collagen synthesis in fibroblasts
Lactic acid · International Journal of Biological Macromolecules, 2024Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo
Sodium lauryl sulfate · The Journal of Investigative Dermatology, 2008Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo
Chamomile flower extract, Chamomile, Chamomilla recutita flower extract matricaria flower extract, Chamomilla recutita flower extract, Chamomilla recutita extract, Chamomile extract · International Journal of Molecular Medicine, 2016Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract
Centella asiatica extract, Madecassoside, Centella asiatica leaf water, Madecassic acid, Centella 4x complex, Centella asiatica, Asiaticoside, Fermented centella asiatica · Indian Journal of Pharmaceutical Sciences, 2016Effects of petrolatum on stratum corneum structure and function
White soft paraffin · Journal of the American Academy of Dermatology, 1992Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling
Panax ginseng root extract, Panax ginseng extract · Journal of Ethnopharmacology, 2007Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes
Hydrolyzed ginseng saponins · Journal of Ginseng Research, 2022The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy
Centella asiatica extract, Centella asiatica leaf water, Centella asiatica · Pharmaceutics, 2024Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing
Hydrolyzed haematococcus pluvialis extract · Nutrients, 2021Topical application of green and white tea extracts provides protection from solar-simulated ultraviolet light in human skin
White tea · Experimental Dermatology, 2009Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin
Squalane · Scientific Reports, 2020Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1
Tremella fuciformis sporocarp extract silver ear mushroom extract · Molecular Medicine Reports, 2017Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects
Ubiquinone · BioFactors, 2015Effect of fermentation time on the content of bioactive compounds with cosmetic and dermatological properties in Kombucha Yerba Mate extracts
Saccharomyces xylinum black tea ferment · Scientific Reports, 2021Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Propolis extract, Aloe barbadensis leaf juice, Aloe barbadensis extract, Aloe barbadensis juice, Aloe barbadensis leaf extract, Aloe barbadensis leaf juice powder, Aloe barbadensis, Aloe barbadensis leaf water, Melaleuca alternifolia tree extract, Aloe barbadensis leaf, Melaleuca alternifolia tree oil leaf · Clinical Pharmacology, 2018Use of Collagen in Cosmetic Products
Collagen, Water-soluble collagen, Collagen including hydrolyzed collagen atelocollagen · Current Issues in Molecular Biology, 2024Antioxidant properties evaluation of topical astaxanthin formulations as anti-aging products
Algae extract, Astaxanthin extract · Journal of Cosmetic Dermatology, 2019Urea: a comprehensive review of the clinical literature
Urea · Dermatology Online Journal, 2013A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin
Camellia sinensis leaf extract extract, Camellia sinensis, Epigallocatechin gallate · The Journal of Investigative Dermatology, 2019α-Linolenic acid and linoleic acid modulate the lipidome and the skin barrier of a tissue-engineered skin model
Linolenic acid · Acta Biomaterialia, 2022Moringa oleifera Leaf Extracts as Multifunctional Ingredients for "Natural and Organic" Sunscreens and Photoprotective Preparations
Moringa oleifera extract · Molecules, 2018Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes
Lepidium sativum extract sprout · Pharmacological Research, 2013Effect of Camellia japonica oil on human type I procollagen production and skin barrier function
Rose of winter extract, Camellia japonica seed oil, Camellia japonica flower extract · Journal of Ethnopharmacology, 2007Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin
Ceramide, Ceramides, Phytoceramides, Ceraplex 5-ceramide blend · Scientific Reports, 2022Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles
Rosemary · Pharmaceutics, 2017Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin
Glyceryl glucoside · Skin Pharmacology and Physiology, 2012Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes
Opuntia ficus-indica stem extract, Cactus extract · Journal of Medicinal Food, 2015The safety and efficacy of bacterial nanocellulose wound dressing incorporating sericin and polyhexamethylene biguanide: in vitro, in vivo and clinical studies
Silk extract · Archives of Dermatological Research, 2016Calendula extract: effects on mechanical parameters of human skin
Calendula officinalis flower water · Acta Poloniae Pharmaceutica, 2011Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial
Melatonin · Clinical, Cosmetic and Investigational Dermatology, 2018Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study
Ascorbic acid · Clinical Oral Investigations, 2021Artichoke Polyphenols Produce Skin Anti-Age Effects by Improving Endothelial Cell Integrity and Functionality
Cynara scolymus extract · Molecules, 2018Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin
Ceramide np, Ceramide eop, Ceramide-3 · International Journal of Dermatology, 2008Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin
Xylitol, Xylitylglucoside · Acta Dermato-venereologica, 2017Transdermal delivery enhancement of carvacrol from Origanum vulgare L. essential oil by microemulsion
Micro-oils · International Journal of Pharmaceutics, 2020The topical effect of grape seed extract 2% cream on surgery wound healing
Palmitoyl grape seed extract · Global Journal of Health Science, 2014Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Ascorbic acid, Tocopherol vitamin e, Tocopherol, Ferulic acid · Journal of Cosmetic Dermatology, 2020Clinical efficacy comparison of anti-wrinkle cosmetics containing herbal flavonoids
Aspalathus linearis · International Journal of Cosmetic Science, 2010A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations
Arbutin · Journal of Cosmetic Dermatology, 2015Injectable thermo-sensitive and wide-crack self-healing hydrogel loaded with antibacterial anti-inflammatory dipotassium glycyrrhizate for full-thickness skin wound repair
Dipotassium glycyrrhizate · Acta Biomaterialia, 2022Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo
Licorice root extract, Glycyrrhiza glabra root extract licorice root extract, Glycyrrhiza glabra extract, Glycyrrhiza glabra extract licorice extract · Experimental Dermatology, 2015Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study
Retinyl palmitate, Retinol palmitate vitamin a, Retinyl palmitate vitamin a · International Journal of Nanomedicine, 2021Epilobium angustifolium extract demonstrates multiple effects on dermal fibroblasts in vitro and skin photo-protection in vivo
Epilobium angustifolium stem extract flower leaf · General Physiology and Biophysics, 2013Efficacy of probiotic-derived lotion from Lactobacillus paracasei MSMC 39-1 in mild to moderate acne vulgaris, randomized controlled trial
Lactobacillus · Journal of Cosmetic Dermatology, 2022Hesperidin, Hesperetin, Rutinose, and Rhamnose Act as Skin Anti-Aging Agents
Rhamnose · Molecules, 2023Clinical Studies on Topical Curcumin
Curcuma longa root extract · Skin Pharmacology and Physiology, 2023The use of green tea extract in cosmetic formulations: not only an antioxidant active ingredient
Jeju green tea extract · Dermatologic Therapy, 2013Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls
Camellia sinensis leaf extract · Experimental Dermatology, 2009Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration
Argania spinosa kernel oil, Argania spinosa kernel oil argan kernel oil, Oil tree · International Journal of Nanomedicine, 2014Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin
Centella asiatica leaf extract · Experimental Dermatology, 2008Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris
Azelaic acid · Pharmaceutics, 2021Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy
Resveratrol, Polygonum cuspidatum root extract · Molecules, 2023Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin
Avena sativa kernel extract oat kernel extract, Avena sativa seed oat seed water seed · Journal of Drugs in Dermatology, 2015Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract
Punica granatum seed oil · Drug Design, Development and Therapy, 2017Role of Resveratrol in Regulating Cutaneous Functions
Polygonum cuspidatum root extract · Evidence-based Complementary and Alternative Medicine, 2020Mechanistic Wound Healing and Antioxidant Potential of Moringa oleifera Seeds Extract Supported by Metabolic Profiling, In Silico Network Design, Molecular Docking, and In Vivo Studies
Moringa oleifera seed extract · Antioxidants, 2022A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin
Myristyl nicotinate, Niacin · Experimental Dermatology, 2007Tailored Limonene-Based Nanosized Microemulsion: Formulation, Physicochemical Characterization and In Vivo Skin Irritation Assessment
Micro-oils · Advanced Pharmaceutical Bulletin, 2021Continuous topical administration of a petrolatum formulation by a novel disposable diaper. 2. Effect on skin condition
Liquid paraffin ph.eur, White petrolatum, Petroleum jelly · Dermatology, 2000The moisturizing effects of glycolipid biosurfactants, mannosylerythritol lipids, on human skin
Glycolipids · Journal of Oleo Science, 2012The clinical effect of glutathione on skin color and other related skin conditions: A systematic review
Glutathione · Journal of Cosmetic Dermatology, 2019The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle
Thioctic acid · European Journal of Pharmaceutics and Biopharmaceutics, 2014Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study
Melaleuca alternifolia tree oil leaf · Dermatology, 2014Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine
Evodia rutaecarpa fruit extract · Journal of Dermatological Science, 2006The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin, Madecassoside, Madecassic acid, Concentrated glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial
Madecassoside, Centella asiatica leaf water, Asiaticoside, Madecassic acid · Journal of Alternative and Complementary Medicine, 2020Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide · Journal of Cosmetic Dermatology, 2021Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis
Schisandra sphenanthera fruit extract · Planta Medica, 2007Niacinamide mitigates SASP-related inflammation induced by environmental stressors in human epidermal keratinocytes and skin
Gentlebright complex · International Journal of Cosmetic Science, 2020Skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) incorporated into hydrogel
Ascorbyl palmitate · Die Pharmazie, 2005α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis
Palmitoyl grapevine shoot extract · Theranostics, 2018Effects of cosmetics containing purified honeybee (Apis mellifera L.) venom on acne vulgaris
Bee venom · Journal of Integrative Medicine, 2013Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial
Acetyl glucosamine, Neoglucosamine, N-acetyl glucosamine · The British Journal of Dermatology, 2010Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine
Acetyl glucosamine, Neoglucosamine, N-acetyl glucosamine · Journal of Cosmetic Dermatology, 2007Paeoniflorin attenuates ultraviolet B-induced apoptosis in human keratinocytes by inhibiting the ROS-p38-p53 pathway
Paeonia albiflora root extract · Molecular Medicine Reports, 2016Stable Liposome in Cosmetic Platforms for Transdermal Folic acid delivery for fortification and treatment of micronutrient deficiencies
Micro-nutrients · Scientific Reports, 2018Cytotoxicity of lecithin-based nanoemulsions on human skin cells and ex vivo skin permeation: Comparison to conventional surfactant types
Hydrogenated lecithin · International Journal of Pharmaceutics, 2019Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides
Palmitoyl pentapeptide-4 · Advanced Science, 2025Poly-L-Lactic acid increases collagen gene expression and synthesis in cultured dermal fibroblast (Hs68) through the TGF-β/Smad pathway
Lactic acid · Journal of Cosmetic Dermatology, 2023Synergism of plant extract and vegetable oils-based lipid nanocarriers: Emerging trends in development of advanced cosmetic prototype products
Daucus carota sativa seed oil carrot seed oil, Phytonutrient blend · Materials Science & Engineering. C, Materials for Biological Applications, 2020Oleanolic Acid Protects the Skin from Particulate Matter-Induced Aging
Oleanolic acid · Biomolecules & Therapeutics, 2021The Herbal Bitter Drug Gentiana lutea Modulates Lipid Synthesis in Human Keratinocytes In Vitro and In Vivo
Gentiana lutea extract · International Journal of Molecular Sciences, 2017Encapsulation and controlled release of retinol from silicone particles for topical delivery
Pro-retinol a · Journal of Controlled Release, 2018Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling
Leontopodium alpinum leaf extract flower · Genes, 2020Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells
Leontopodium alpinum leaf extract flower · Mediators of Inflammation, 2012The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties
Algae extract · Journal of Cosmetic Science, 2002Protective effects of Camellia japonica flower extract against urban air pollutants
Camellia japonica flower extract · BMC Complementary and Alternative Medicine, 2019Role of epidermal γδ T-cell-derived interleukin 13 in the skin-whitening effect of Ginsenoside F1
Panax ginseng flower extract · Experimental Dermatology, 2014Evaluation of Cosmetic and Dermatological Properties of Kombucha-Fermented Berry Leaf Extracts Considered to Be By-Products
Saccharomyces xylinum black tea ferment · Molecules, 2022The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial
Kinetin · Journal of Cosmetic Dermatology, 2007Development of Polymeric Micelles of Oleanolic Acid and Evaluation of Their Clinical Efficacy
Oleanolic acid · Nanoscale Research Letters, 2020A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen
Pro-retinol, Retinyl propionate · The British Journal of Dermatology, 2010A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol, Vitamin b5, Vitamin b5 panthenol, Pantothenic acid, Panthenol vitamin b5, Panthenol vb5 · The Journal of Dermatological Treatment, 2017Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide, Vitamins b3 · Scientific Reports, 2024A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid · BioMed Research International, 2020Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation
Tocopheryl acetate, Tocopheryl acetate vitamin e, Vitamin e tocopheryl acetate · Urologia Internationalis, 2019Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB
Magnolia officinalis bark extract · European Journal of Pharmacology, 2007Application of Standardized Rosa damascena Stem Cell-Derived Exosomes in Dermatological Wound Healing and Scar Management: A Retrospective Case-Series Study with Long-Term Outcome Assessment
Rosa damascena flower extract, Damascan rose · Pharmaceutics, 2025Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study
Glycolic acid · Journal of Cosmetic Dermatology, 2019Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy
Flower extract, Extracts flower · Phytotherapy Research, 2011Formulation and evaluation on human skin of a water-in-oil emulsion containing Muscat hamburg black grape seed extract
Vitis vinifera seed extract grape seed extract, Grape seed oil, Palmitoyl grape seed extract, Grape seed extract · International Journal of Cosmetic Science, 2015Phytosphingosine enhances moisture level in human skin barrier through stimulation of the filaggrin biosynthesis and degradation leading to NMF formation
Hydration complex · Archives of Dermatological Research, 2017Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-beta-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin(R))
Boswellia carterii oil · Toxicology Mechanisms and Methods, 2006Ascorbic Acid Treatments as Effective and Safe Anti-Aging Therapies for Sensitive Skin
Ascorbyl palmitate ascorbic acid · Antioxidants, 2024Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration
Adenosine · International Journal of Cosmetic Science, 2018A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial
Melaleuca alternifolia tree oil leaf, Melaleuca alternifolia tree leaf extract, Melaleuca alternifolia tree extract · Archives of Dermatological Research, 2022Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris
Mandelic acid · Journal of Cosmetic Dermatology, 2020Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system
Retinyl palmitate · Colloids and Surfaces. B, Biointerfaces, 2011Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide
Moisturizing factors nmf, Glyceryl glucoside, Moisturizing factors · The Journal of Clinical and Aesthetic Dermatology, 2012Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant
Caffeine · Frontiers in Physiology, 2019Effects of lecithin-based nanoemulsions on skin: Short-time cytotoxicity MTT and BrdU studies, skin penetration of surfactants and additives and the delivery of curcumin
Hydrogenated lecithin · International Journal of Pharmaceutics, 2020Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes
Collagen amino acids, Collagen extract · Nutrients, 2022Efficacy and tolerability assessment of a topical formulation containing copper sulfate and hypericum perforatum on patients with herpes skin lesions: a comparative, randomized controlled trial
Copper sulfate · Journal of Drugs in Dermatology, 2012Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin
Thioctic acid, Alpha lipoic acid · The British Journal of Dermatology, 2003Topical beta-carotene protects against infra-red-light-induced free radicals
Carrot carotene, Beta-carotene · Experimental Dermatology, 2011Hydroxypropyl methylcellulose hydrogel of berberine chloride-loaded escinosomes: Dermal absorption and biocompatibility
Enantia chlorantha bark extract, Coptis japonica root extract · International Journal of Biological Macromolecules, 2020Safflower Seed Oil and Its Active Compound Acacetin Inhibit UVB-Induced Skin Photoaging
Carthamus tinctorius seed oil · Journal of Microbiology and Biotechnology, 2020Fermented pomegranate extracts protect against oxidative stress and aging of skin
Punica granatum extract · Journal of Cosmetic Dermatology, 2022The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Gluconolactone, Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study
Vitamin c derivatives, Tetrahexyldecyl ascorbate, Ascorbic acid ester, Ascorbyl tetraisopalmitate, Tetrahexydecyl ascorbate · Photochemistry and Photobiology, 2021Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
Panthenol, Allantoin, Panthenol vitamin b5 · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects
Blueberry fruit extract · Clinical, Cosmetic and Investigational Dermatology, 2020High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin
Witch hazel leaf extract bark, Witch hazel, Witch hazel water, Witch hazel extract, Witch hazel leaf extract, Hammamelis extract · Phytochemistry, 2001Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days
Tetrahexyldecyl ascorbate, Ascorbyl tetraisopalmitate, Tetrahexydecyl ascorbate · Journal of Cosmetic Dermatology, 2019Anti-melanogenic property of ginsenoside Rf from Panax ginseng via inhibition of CREB/MITF pathway in melanocytes and ex vivo human skin
Panax ginseng root extract, Panax ginseng extract · Journal of Ginseng Research, 2021A pilot randomized double-blind placebo-controlled trial on topical chamomile (Matricaria chamomilla L.) oil for severe carpal tunnel syndrome
Chamomilla recutita flower extract matricaria flower extract · Complementary Therapies in Clinical Practice, 2015Topical glutathione amino acid precursors protect skin against environmental and oxidative stress
Acyl-glutathione, Glutathione · Journal of the European Academy of Dermatology and Venereology, 2024Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts
Hexapeptide-11 · Redox Biology, 2015Snail Slime Extracted by a Cruelty Free Method Preserves Viability and Controls Inflammation Occurrence: A Focus on Fibroblasts
Snail secretion filtrate · Molecules, 2023Self-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol
Paeonia suffruticosa branch leaf extract flower, Cynanchum atratum extract · Medical Science Monitor, 2015Efficacy of Oxybrasion in the Treatment of Acne Vulgaris: A Preliminary Report
Sea salt · Journal of Clinical Medicine, 2022Mechanism of action and clinical benefits of colloidal oatmeal for dermatologic practice
Avena sativa kernel extract · Journal of Drugs in Dermatology, 2010Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways
Tremella fuciformis polysaccharide, Tremella fuciformis sporocarp extract · Journal of Cosmetic Dermatology, 2021Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy
Centella asiatica extract, Madecassoside, Centella asiatica leaf water, Centella asiatica, Centella asiatica leaf extract, Paeonia albiflora flower extract, Centella 4x complex, Paeonia suffruticosa branch leaf extract flower, Fermented centella asiatica, Cynanchum atratum extract, Paeonia suffruticosa extract · Molecules, 2023A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne
Gluconolactone · The Australasian Journal of Dermatology, 1992Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-8, Peptide 9 · Annals of Dermatology, 2019Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula
Saccharomyces rice ferment filtrate, Saccharomyces ferment filtrate, Galactomyces ferment filtrate, Pitera ferment filtrate, Rice ferment filtrate sake ferment filtrate · Journal of Clinical Medicine, 2021In vivo anti-ageing activity of cream containing niosomes loaded with purple glutinous rice (Oryza sativa Linn.) extract
Rice extract, Rice seed extract · International Journal of Cosmetic Science, 2020Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging
1 · Journal of Traditional and Complementary Medicine, 2021Allergy to oxidized limonene and linalool is frequent in the U.K
Citrus aurantium dulcis peel oil, Linalool · The British Journal of Dermatology, 2014Anti-inflammatory activity of parthenolide-depleted Feverfew (Tanacetum parthenium)
Chrysanthemum parthenium extract · Inflammopharmacology, 2009Plantago lanceolata L. water extract induces transition of fibroblasts into myofibroblasts and increases tensile strength of healing skin wounds
Plantago lanceolata leaf extract · The Journal of Pharmacy and Pharmacology, 2015Characterization of Acne-Prone Skin with Reflectance Confocal Microscopy and Optical Coherence Tomography and Modifications Induced by Topical Treatment and Probiotic Supplementation
Hydroxypinacolone retinoate · Journal of Clinical Medicine, 2023The Effects of Filtrate of the Secretion of the Cryptomphalus Aspersa on Photoaged Skin
Sca · Journal of Drugs in Dermatology, 2013The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro
Bifida lysate ferment, Bifida ferment filtrate · Journal of Cosmetic Dermatology, 2023Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid · Journal of Cosmetic Dermatology, 2024Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects
Vitamin e · Journal of Cosmetic Dermatology, 2020Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function
Salvia officinalis leaf extract, Melissa officinalis stem extract flower leaf, Rosamarinus officinalis leaf extract rosemary leaf extract · International Journal of Molecular Sciences, 2022Effects of seaweed Laminaria japonica extracts on skin moisturizing activity in vivo
Marine algae · Journal of Cosmetic Science, 2013Night Cream Containing Melatonin, Carnosine and Helichrysum italicum Extract Helps Reduce Skin Reactivity and Signs of Photodamage: Ex Vivo and Clinical Studies
Helichrysum italicum extract, Helichrysum italicum oil flower · Dermatology and Therapy, 2020Inhibition of TRPV1 prevented skin irritancy induced by phenoxyethanol. A preliminary in vitro and in vivo study
Phenoxyethanol · International Journal of Cosmetic Science, 2017Tremella fuciformis Inhibits Melanogenesis in B16F10 Cells and Promotes Migration of Human Fibroblasts and Keratinocytes
Tremella fuciformis sporocarp extract silver ear mushroom extract, Tremella fuciformis sporocarp extract · In Vivo, 2022High-Payload Nanosuspension of Centella asiatica Extract for Improved Skin Delivery with No Irritation
Asiaticoside · International Journal of Nanomedicine, 2021The Combined Anti-Aging Effect of Hydrolyzed Collagen Oligopeptides and Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells on Human Skin Fibroblasts
Collagen extract · Molecules, 2024Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach
Zinc oxide, Zinc · Journal of Controlled Release, 2025Polyglycerol Ester-Based Low Energy Nanoemulsions with Red Raspberry Seed Oil and Fruit Extracts: Formulation Development toward Effective In Vitro/In Vivo Bioperformance
Raspberry seed oil · Nanomaterials, 2021Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study
Jojoba seed oil, Jojoba oil, Jojoba · Forschende Komplementarmedizin, 2012A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid
3 essential ceramides, Ceramide np, 5-ceramide complex, Ceramide-3 · Skin Pharmacology and Physiology, 2022Preparation and evaluation of anti-wrinkle cream containing saffron extract and avocado oil
Avocado oil, Persea gratissima oil avocado oil, Persea gratissima fruit extract avocado fruit extract, Avocado · Journal of Cosmetic Dermatology, 2020Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications
Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1, Palmitoyl hexapeptide-12, Palmitoyl oligopeptide, Matrixyl 3000, 9 signal peptides · Journal of Cosmetic Dermatology, 2015Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
Sodium ascorbyl phosphate · International Journal of Cosmetic Science, 2009Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans
Raspberry ketone · Growth Hormone & IGF Research, 2008Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy
Sodium lauryl sulfate · Pharmaceutics, 2021Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol
Hexylresorcinol · Journal of Drugs in Dermatology, 2016Lecithin-based nanoemulsions of traditional herbal wound healing agents and their effect on human skin cells
Hydrogenated lecithin · European Journal of Pharmaceutics and Biopharmaceutics, 2022Hormesis-based anti-aging products: a case study of a novel cosmetic
Hydrolyzed ginseng saponins · Dose-response, 2013A review of protection against exposome factors impacting facial skin barrier function with 89% mineralizing thermal water
Vichy mineralizing water · Journal of Cosmetic Dermatology, 2019Chemical peels for acne vulgaris: a systematic review of randomised controlled trials
Mandelic acid · BMJ Open, 2018Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques
Tetrahexyldecyl ascorbate, Ascorbyl tetraisopalmitate · European Journal of Pharmaceutics and Biopharmaceutics, 2017A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid · Journal of Drugs in Dermatology, 2023Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs
Vitamin e · Journal of Cosmetic Dermatology, 2022Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial
Pantothenic acid, Centella asiatica leaf extract, Copper · Journal of Cosmetic Dermatology, 2019Retaining Skin Barrier Function Properties of the Stratum Corneum with Components of the Natural Moisturizing Factor-A Randomized, Placebo-Controlled Double-Blind In Vivo Study
Moisturizing factors nmf, Moisturizing factors, Hydration complex · Molecules, 2021Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin
Acetyl dipeptide-1 cetyl ester · Journal of the European Academy of Dermatology and Venereology, 2016Anti-pollution cosmetic-based one-step formation of w/o/w multiple emulsion containing D-biotin for skin protection: fabrication and in vitro and in vivo evaluation
Biotin · Drug Delivery and Translational Research, 2019Exotic Vegetable Oils for Cosmetic O/W Nanoemulsions: In Vivo Evaluation
Lanolin, Lanolin alcohol eucerit, Anhydrous lanolin medilan · Molecules, 2016Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris
Azelaic acid · Dermatology and Therapy, 2024The anti-inflammatory effect of cherry blossom extract (Prunus yedoensis) used in soothing skincare product
Cherry blossom extract · International Journal of Cosmetic Science, 2014In vitro and in vivo studies with tetra-hydro-jasmonic acid (LR2412) reveal its potential to correct signs of skin ageing
Jasmonic acid · Journal of the European Academy of Dermatology and Venereology, 2014Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies
Alpha-arbutin · Heliyon, 2023Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study
1 · Scientific Reports, 2023The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols
2-hexanediol · International Journal of Cosmetic Science, 2011Colloidal Oatmeal <em>(Avena Sativa)</em> Improves Skin Barrier Through Multi-Therapy Activity
Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2016Oxidized citrus oil (R-limonene): a frequent skin sensitizer in Europe
Citrus aurantium dulcis peel oil · Journal of the American Academy of Dermatology, 2002Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide
Hexylresorcinol · International Journal of Cosmetic Science, 2022A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial
Mannitol, Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015Potentially beneficial effects of rhamnose on skin ageing: an in vitro and in vivo study
Rhamnose · International Journal of Cosmetic Science, 2019Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection
Rice germ oil, Rice extract · Pharmaceuticals, 2023In Vivo skin hydration and anti-erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications
Aloe ferox leaf extract · Pharmacognosy Magazine, 2014Exploring the antioxidant potentiality of two food by-products into a topical cream: stability, in vitro and in vivo evaluation
Botanical alfalfa concentrate · Drug Development and Industrial Pharmacy, 2016Development of Phytocosmeceutical Microemulgel Containing Flaxseed Extract and Its In Vitro and In Vivo Characterization
Linum usitatissimum seed extract · Pharmaceutics, 2022Semi-Solid Dosage Forms Containing Pranoprofen-Loaded NLC as Topical Therapy for Local Inflammation: In Vitro, Ex Vivo and In Vivo Evaluation
Carbomer · Gels, 2023Liposome, gel and lipogelosome formulations containing sodium hyaluronate
4d hyaluronic acid · Journal of Liposome Research, 2014Topical application of superoxide dismutase mediated by HIV-TAT peptide attenuates UVB-induced damages in human skin
Superoxide dismutase · European Journal of Pharmaceutics and Biopharmaceutics, 2016Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model
Jojoba seed oil · Frontiers in Pharmacology, 2024Evaluating the Safety and Efficacy of a Topical Formulation Containing Epidermal Growth Factor, Tranexamic Acid, Vitamin C, Arbutin, Niacinamide and Other Ingredients as Hydroquinone 4% Alternatives to Improve Hyperpigmentation: A Prospective, Randomized, Controlled Split Face Study
Arbutin · Journal of Cosmetic Science, 2020Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function
Propanediol · International Journal of Cosmetic Science, 2024Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial
Zinc pca · The Journal of Clinical and Aesthetic Dermatology, 2020Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations
Vitamin e · Journal of Cosmetic Dermatology, 2022A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors
Rose extract, Rosa centifolia flower extract · Molecules, 2020Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release
Oenothera biennis oil, Oenothera biennis evening primrose oil · Biomaterials Advances, 2022Comparison of the Efficacy of Atopalm(®) Multi-Lamellar Emulsion Cream and Physiogel(®) Intensive Cream in Improving Epidermal Permeability Barrier in Sensitive Skin
Mle multi-lamellar emulsion technology · Dermatology and Therapy, 2016Subclinical cutaneous inflammation remained after permeability barrier disruption enhances UV sensitivity by altering ER stress responses and topical pseudoceramide prevents them
Hydroxypropyl bispalmitamide mea ceramide, Myristoyl palmitoyl oxostearamide arachamide mea, Ceramide ng · Archives of Dermatological Research, 2017Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin
Magnesium ascorbyl phosphate, Kinetin · Photochemistry and Photobiology, 2012Safety and efficacy of Sclerocarya birrea (A.Rich.) Hochst (Marula) oil: A clinical perspective
Sclerocarya birrea seed oil, Unrefined sclerocarya birrea kernel oil sclerocarya birrea kernel oil · Journal of Ethnopharmacology, 2015Snail Mucus Filtrate Reduces Inflammation in Canine Progenitor Epidermal Keratinocytes (CPEK)
Black snail mucin filtrate · Animals, 2022Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study
Zinc gluconate · Clinical, Cosmetic and Investigational Dermatology, 2023A novel model of inflammatory pain in human skin involving topical application of sodium lauryl sulfate
Sodium lauryl sulfate · Inflammation Research, 2010Efficacy and tolerability of the investigational topical cream SD-101 (6% allantoin) in patients with epidermolysis bullosa: a phase 3, randomized, double-blind, vehicle-controlled trial (ESSENCE study)
Allantoin · Orphanet Journal of Rare Diseases, 2020Challenging the safety and efficacy of topically applied chlorogenic acid, apigenin, kaempferol, and naringenin by HET-CAM, HPLC-TBARS-EVSC, and laser Doppler flowmetry
Cynara scolymus extract · Frontiers in Chemistry, 2024Kinetin Improves Barrier Function of the Skin by Modulating Keratinocyte Differentiation Markers
Kinetin · Annals of Dermatology, 2017Clinical evaluation of fullerene-C60 dissolved in squalane for anti-wrinkle cosmetics
Phytosqualane · Journal of Nanoscience and Nanotechnology, 2010Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Citric acid, Capryloyl salicylic acid · Journal of Cosmetic Dermatology, 2021Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract
Camellia sinensis leaf extract, Camellia sinensis leaf water, Black tea extract, Aloe barbadensis flower extract, White tea · Clinical, Cosmetic and Investigational Dermatology, 2019The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study
Acetyl hexapeptide-8, Tripeptide-10 citrulline · Journal of Cosmetic Dermatology, 2017Black rice (Oryza sativa L.) extract modulates ultraviolet-induced expression of matrix metalloproteinases and procollagen in a skin cell model
Rice extract · International Journal of Molecular Medicine, 2018Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters
Ectoin · Journal of Cosmetic Dermatology, 2024Whitening effect of alpha-bisabolol in Asian women subjects
Bisabolol, Alpha-bisabolol · International Journal of Cosmetic Science, 2010The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study
Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023Formulation and evaluation of antisebum secretion effects of sea buckthorn w/o emulsion
Hippophae rhamnoides · Journal of Pharmacy & Bioallied Sciences, 2010A Study of Efficacy and Safety of Ashwagandha (Withania somnifera) Lotion on Facial Skin in Photoaged Healthy Adults
Ashwagandha · Cureus, 2023The anti-photoaging effect of C-phycocyanin on ultraviolet B-irradiated BALB/c-nu mouse skin
Spirulina platensis extract · Frontiers in Bioengineering and Biotechnology, 2023In Vitro and Clinical Safety Assessment of the Multiple W/O/W Emulsion Based on the Active Ingredients from Rosmarinus officinalis L., Avena sativa L. and Linum usitatissimum L
Avena sativa kernel extract oat kernel extract · Pharmaceutics, 2021Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane
Cyclopentasiloxane · International Journal of Toxicology, 2011Is benzyl alcohol a significant contact sensitizer?
Benzyl alcohol · Journal of the European Academy of Dermatology and Venereology, 2022The Moisturizing Efficacy of a Proprietary Dermo-Cosmetic Product( CLS02021) Versus Placebo in a 4-week Application Period
Proprietary · Medical Archives, 2022Partially purified paeoniflorin exerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin
Paeonia albiflora root extract · Journal of Cosmetic Science, 2006Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study
Beta-glucan · Journal of Cosmetic Dermatology, 2021Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison
Willow bark extract, Willow extract · Journal of Cosmetic Dermatology, 2019Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract
Willow bark extract, Willow extract · Planta Medica, 2019Apple Extract (Malus sp.) and Rutin as Photochemopreventive Agents: Evaluation of Ultraviolet B-Induced Alterations on Skin Biopsies and Tissue-Engineered Skin
Pyrus malus fruit extract, Pyrus malus extract · Rejuvenation Research, 2020Development of Sponge Microspicule Cream as a Transdermal Delivery System for Protein and Growth Factors from Deer Antler Velvet Extract
Velvet extract · Biological & Pharmaceutical Bulletin, 2019TriHex 2.0-Advancing Skin Health Science and the TriHex Technology
Octapeptide-45 · Journal of Cosmetic Dermatology, 2025Comedogenicity in rabbit: some cosmetic ingredients/vehicles
Isopropyl myristate, Isopropyl isostearate · Cutaneous and Ocular Toxicology, 2007Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers
Sodium ascorbyl phosphate, Ascorbyl palmitate · Drug Research, 2017Inhibitory effects of shell of Camellia oleifera Abel extract on mushroom tyrosinase and human skin melanin
Butylene glycol · Journal of Cosmetic Dermatology, 2019Annurca Apple Oleolite as Functional Ingredient for the Formulation of Cosmetics with Skin-Antiaging Activity
1 · International Journal of Molecular Sciences, 2024In vivo spectrophotometric evaluation of skin barrier recovery after topical application of soybean phytosterols
Phytosterols · Journal of Cosmetic Science, 2008An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging
Willow bark extract · Journal of Cosmetic Dermatology, 2010Biochemical Pilot Study on Effects of Pomegranate Seed Oil Extract and Cosmetic Cream on Neurologically Mediated Skin Inflammation in Animals and Humans: A Comparative Observational Study
Punica granatum seed oil · Molecules, 2023Neuroimmunomodulatory compound for sensitive skin care: in vitro and clinical assessment
Carnosine · Journal of Cosmetic Dermatology, 2008Tolerance and efficacy of a product containing ellagic and salicylic acids in reducing hyperpigmentation and dark spots in comparison with 4% hydroquinone
Strawberry fruit extract · Journal of Drugs in Dermatology, 2013Therapeutic Benefits of Topical Omega-3 Polyunsaturated Fatty Acids in Skin Diseases and Cosmetics: An Updated Systematic Review
Fatty acids · Journal of Cosmetic Dermatology, 2025Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression
Chrysanthemum parthenium extract · Archives of Dermatological Research, 2008Assessment of Cosmetic and Dermatological Properties and Safety of Use of Model Skin Tonics with Kombucha-Fermented Red Berry Extracts
Saccharomyces xylinum black tea ferment · International Journal of Molecular Sciences, 2022'All-natural' anti-wrinkle emulsion serum with Acmella oleracea extract: A design of experiments (DoE) formulation approach, rheology and in vivo skin performance/efficacy evaluation
Acmella oleracea extract · International Journal of Cosmetic Science, 2021Improvement of Biophysical Skin Parameters of Topically Applied Fermented Soybean Extract-Loaded Niosomes with No Systemic Toxicity in Ovariectomized Rats
Bean extract · Pharmaceutics, 2021Comparative benefit of two thermal spring waters after photodynamic therapy procedure
Avène thermal spring water · Journal of Cosmetic Dermatology, 2007Assessment of cubosomal alpha lipoic acid gel efficacy for the aging face: a single-blinded, placebo-controlled, right-left comparative clinical study
Thioctic acid, Alpha lipoic acid · Journal of Cosmetic Dermatology, 2017Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin
Capryloyl salicylic acid · Journal of Cosmetic Dermatology, 2008Efficacy of ceramides and niacinamide-containing moisturizer versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris: A split face, double-blinded, randomized controlled trial
Phytoceramides · Journal of Cosmetic Dermatology, 2024Oleanolic Acid Nanofibers Attenuated Particulate Matter-Induced Oxidative Stress in Keratinocytes
Oleanolic acid · Antioxidants, 2021Spirulina, Palmaria Palmata, Cichorium Intybus, and Medicago Sativa extracts in cosmetic formulations: an integrated approach of in vitro toxicity and in vivo acceptability studies
Botanical alfalfa concentrate · Cutaneous and Ocular Toxicology, 2019A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris
Rhus semialata gall extract · Dermatologic Therapy, 2020The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging
Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023Skin improvement and stability of Echinacea purpurea dermatological formulations
Echinacea greenenvy · International Journal of Cosmetic Science, 2010Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects
Punica granatum extract · Postepy Dermatologii I Alergologii, 2014Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders
3-o-ethyl ascorbic acid, 2-o-ethyl ascorbic acid, 3-o-ethyl-ascorbic acid · Polymers, 2023Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids
Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
Adenosine · Journal of Cosmetic Dermatology, 2019Stability, antioxidant activity, in vivo safety and efficacy of creams with standardized wild apple fruit extract: a comparison of conventional and biodegradable emulsifiers
Pyrus malus fruit extract · International Journal of Cosmetic Science, 2019Morinda citrifolia Linn. (Rubiaceae) leaf extracts mitigate UVB-induced erythema
Morinda citrifolia extract · Journal of Natural Medicines, 2009Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast
Squalane, Olive squalane, Squalane oil · Molecules, 2025Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits
Betula alba juice · International Journal of Molecular Sciences, 2022A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric
Astaxanthin extract, Astaxanthin · Journal of Cosmetic Dermatology, 2023Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment
Centella asiatica leaf extract, Asiatic acid · International Journal of Pharmaceutics, 2024Neryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrier
Helichrysum italicum extract · PloS One, 2023Polygonum multiflorum Radix extract protects human foreskin melanocytes from oxidative stress in vitro and potentiates hair follicle pigmentation ex vivo
Polygonum multiflorum root extract · International Journal of Cosmetic Science, 2017Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine
Acetyl glucosamine, Neoglucosamine · Advanced Pharmaceutical Bulletin, 2016Antiaging, Brightening, and Antioxidant Efficacy of Fermented Bilberry Extract (Vaccinium myrtillus): A Randomized, Double-Blind, Placebo-Controlled Trial
Vaccinium myrtillus · Nutrients, 2024Effect of facial application of essence containing royal jelly extract on stratum corneum moisture content: A placebo-controlled, double-blind, parallel-group study
Royal jelly extract, Royal jelly · Journal of Cosmetic Dermatology, 2022Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration
Betaine, Aloe barbadensis flower extract · Molecules, 2024Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol
Sorbitol, Sorbitol solution · Journal of Cosmetic Science, 2013Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function
Linum usitatissimum seed oil · Acta Pharmaceutica, 2024Melanogenesis effects of rice protein hydrolysate and its characteristic peptides Leu-Leu-Lys, Leu-Pro-Lys, and pyroGlu-Lys on UVB-induced human epidermal melanocyte cells
Hydrolyzed rice protein · Food & Function, 2020Borage Oil Treated with Immobilized Lipase Inhibits Melanogenesis
Borago officinalis seed oil · Lipids, 2020Expression of differential genes involved in the maintenance of water balance in human skin by Piptadenia colubrina extract
Piptadenia colubrina peel extract · Journal of Cosmetic Dermatology, 2010Preparation, characterization, and application of polysaccharide-based emulsions incorporated with lavender essential oil for skin-friendly cellulosic support
Lavender essential oil · International Journal of Biological Macromolecules, 2021Development of grape seed extract based formulations by using non-invasive biophysical technique and its impact on skin aging
Vitis vinifera seed extract grape seed extract, Grape seed oil · Pakistan Journal of Pharmaceutical Sciences, 2021Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial
Ferulic acid · The Journal of Dermatological Treatment, 2025Noninvasive evaluation of the influence of aucubin-containing cosmetic macroemulsion on selected skin parameters
Plantago lanceolata leaf extract · Journal of Cosmetic Dermatology, 2021Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study
Alteromonas extract ferment · Clinical, Cosmetic and Investigational Dermatology, 20174-n-butylresorcinol dissolving microneedle patch for skin depigmentation: a randomized, double-blind, placebo-controlled trial
4-butylresorcinol · Journal of Cosmetic Dermatology, 2016Wax-oil lubricants to reduce the shear between skin and PPE
Paraffinum liquidum mineral oil · Scientific Reports, 2021Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation
Arbutin · Biomaterials Science, 2023Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo
Phytosphingosine · Journal of Dermatological Science, 2012Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda
Mandelic acid · Journal of Cosmetic Dermatology, 2022Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis
Yeast extract, Hydrolyzed yeast extract · Journal of Clinical Medicine, 2023Axillary hyperhidrosis. Local treatment with aluminium-chloride hexahydrate 25% in absolute ethanol with and without supplementary treatment with triethanolamine
Triethanolamine · Acta Dermato-venereologica, 1988Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota
Camellia sinensis leaf extract · Molecules, 2024Design and in vivo evaluation of emulgel formulations including green tea extract and rose oil
Rose oil, Rosa damascena extract, Rosa damascena oil flower, Damascan rose, The rose essential oil · Acta Pharmaceutica, 2013Comparative measurement of hydration effects of herbal moisturizers
Wheat germ oil · Pharmacognosy Research, 2010Depth-dependent hydration dynamics in human skin: Vehicle-controlled efficacy assessment of a functional 10% urea plus NMF moisturizer by near-infrared confocal spectroscopic imaging (KOSIM IR) and capacitance method complemented by volunteer perception
Moisturizing factors nmf, Moisturizing factors · Skin Research and Technology, 2022Treatment of Postinflammatory Hyperpigmentation Following Acne With Microneedling and Panax Ginseng-Derived Exosomes
Panax ginseng root extract · Plastic and Reconstructive Surgery. Global Open, 2025A dermocosmetic formulation containing Vichy volcanic mineralizing water, Vitreoscilla filiformis extract, niacinamide, hyaluronic acid, and vitamin E regenerates and repairs acutely stressed skin
Vitreoscilla ferment · Journal of the European Academy of Dermatology and Venereology, 2022Topical application of highly concentrated water-in-oil emulsions: Physiological skin parameters and skin penetration in vivo - A pilot study
Isopropyl myristate · International Journal of Pharmaceutics, 2019Effects of Moringa oleifera Seed Oil on Cultured Human Sebocytes In Vitro and Comparison with Other Oil Types
Moringa oleifera seed oil · International Journal of Molecular Sciences, 2023Clinical and sebumetric evaluation of topical emulsions in the treatment of acne vulgaris
Hippophae rhamnoides · Postepy Dermatologii I Alergologii, 2014Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects
Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025Effects of Hydroxydecine(®) (10-hydroxy-2-decenoic acid) on skin barrier structure and function in vitro and clinical efficacy in the treatment of UV-induced xerosis
Royal jelly extract, Royal jelly · European Journal of Dermatology, 2011Investigating the Anti-Aging Effects of Caviar Oil on Human Skin
Caviar extract · In Vivo, 2023Dyspigmentation, skin physiology, and a novel approach to skin lightening
Yeast extract, Strawberry fruit extract · Journal of Cosmetic Dermatology, 2013Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract
Camellia japonica flower extract · FEBS Open Bio, 2021In vivo and ex vivo evaluation of cosmetic properties of seedcakes
Borago officinalis leaf extract · Journal of Cosmetic and Laser Therapy, 2015Formulation of Ascorbic Acid and Betaine-based Therapeutic Deep Eutectic System for Enhanced Transdermal Delivery of Ascorbic Acid
Betaine · Pharmaceutics, 2024Transdermal delivery of elastin peptide assisted by betaine-based deep eutectic solvent to ameliorate skin photoaging
Elastin · Biomaterials Advances, 2024Moisturizing effect of serine-loaded solid lipid nanoparticles and polysaccharide-rich extract of root Phragmites communis incorporated in hydrogel bases
Serine · Archives of Pharmacal Research, 2017Salicyloyl-phytosphingosine: a novel agent for the repair of photoaged skin
Phytosphingosine · International Journal of Cosmetic Science, 2007Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs
Pyrus malus cells stem · Journal of Cosmetic Dermatology, 2016Comparative Analysis of Water Extracts from Roselle (Hibiscus sabdariffa L.) Plants and Callus Cells: Constituents, Effects on Human Skin Cells, and Transcriptome Profiles
Hibiscus sabdariffa flower extract · International Journal of Molecular Sciences, 2023Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug
Glycine soja oil soybean oil · Pharmaceutical Research, 2008Research on antioxidant performance of diglucosyl gallic acid and its application in emulsion cosmetics
Rhus semialata gall extract · International Journal of Cosmetic Science, 2022Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres
Carica papaya fruit extract · Giornale Italiano Di Dermatologia E Venereologia, 2015Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin
Copper tripeptide-1 · Archives of Facial Plastic Surgery, 2006Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation
Collagen amino acid · Molecules, 2021A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo
Shea butter, Aloe barbadensis flower extract, Rosa canina oil fruit, Rosa canina oil rosehip oil · Journal of Cosmetic Dermatology, 2022Influence of vitamin E acetate on stratum corneum hydration
Tocopheryl acetate vitamin e, Tocopheryl acetate · Arzneimittel-Forschung, 1998A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants
Dimethicone · Ostomy/wound Management, 2005Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins
Grape seed extract, Vitis vinifera seed extract grape seed extract, Grape seed oil · Skin Pharmacology and Physiology, 2007Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract
Grape seed extract, Palmitoyl grape seed extract · Journal of Cosmetic Dermatology, 2022Skin recovery by Lavandula angustifolia leaf callus extract: Redox control of Nrf2 signaling
Lavandula angustifolia oil lavender oil, Lavandula angustifolia extract lavender extract · Free Radical Biology & Medicine, 2025Algae extract protection effect on oxidized protein level in human stratum corneum
Algae extract · Annals of the New York Academy of Sciences, 2004Comparative physicochemical stability and clinical anti-wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers
Sodium ascorbyl phosphate, Ascorbic acid ester · Journal of Cosmetic Dermatology, 2021The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively
Betaine · Skin Research and Technology, 2003Emulgels Containing Perilla frutescens Seed Oil, Moringa oleifera Seed Oil, and Mixed Seed Oil: Microemulsion and Safety Assessment
Moringa oleifera seed extract, Moringa oleifera seed oil, Moringa oleifera seed extract moringa seed extract, Drumstick seed oil, Moringa oleifera extract · Polymers, 2022Photoprotective effects of Lithospermum erythrorhizon and Pueraria lobata extracts on UVB-induced photoaging: A study on skin barrier protection
Pueraria lobata root extract · Photodermatology, Photoimmunology & Photomedicine, 2024Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles
Phenylethyl resorcinol · Journal of Cosmetic Dermatology, 2021Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage
Myristyl nicotinate · Experimental Dermatology, 2007Tremella fuciformis polysaccharides alleviates UV-provoked skin cell damage via regulation of thioredoxin interacting protein and thioredoxin reductase 2
Tremella fuciformis sporocarp extract silver ear mushroom extract, Tremella fuciformis tremella mushroom polysaccharide · Photochemical & Photobiological Sciences, 2023The effect of a hydrocolloid dressing containing ceramide-2 on split-thickness wounds in a laser-induced erosion model
Ceramide 2 · Advances in Skin & Wound Care, 2013Highly efficient and compatible shampoo for use after hair transplant
Chamomilla recutita oil flower matricaria oil flower · Clinical, Cosmetic and Investigational Dermatology, 2015Development of a cream formulation containing bee venom and other bee products
Royal jelly · Journal of Cosmetic Dermatology, 2022Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid
Lactobionic acid · Journal of Cosmetic Dermatology, 2010Influence of Panax ginseng formulation on skin microbiota: A randomized, split face comparative clinical study
2-hexanediol · Journal of Ginseng Research, 2022In vitro Percutaneous Absorption of Niacinamide and Phytosterols and in vivo Evaluation of their Effect on Skin Barrier Recovery
Phytosterols · Current Drug Delivery, 2016Anatomical site differences of sodium lauryl sulfate-induced irritation: randomized controlled trial
Sodium lauryl sulfate · The British Journal of Dermatology, 2019Topical Almond Oil for Prevention of Pressure Injuries: A Single-Blinded Comparison Study
Prunus amygdalus dulcis oil · Journal of Wound, Ostomy, and Continence Nursing, 2020Standardized Terminalia chebula Fruit Extract: A Natural Ingredient That Provides Long-Lasting Antioxidant Protection and Reverses Visible Signs of Pollution-Induced Skin Damage
Terminalia chebula fruit extract · Clinical, Cosmetic and Investigational Dermatology, 2021Synergistic action of a triple peptide complex on an essential extra-cellular matrix protein exhibits significant anti-aging benefits
Multi-peptides, Triple peptide · Journal of Cosmetic Dermatology, 2010A novel sophorolipids extraction method by yeast fermentation process for enhanced skin efficacy
Yeast faex extrait de levure extract · Skin Research and Technology, 2023Combined Skin Moisturization of Liposomal Serine Incorporated in Hydrogels Prepared with Carbopol ETD 2020, Rhesperse RM 100 and Hyaluronic Acid
Serine · The Korean Journal of Physiology & Pharmacology, 2015A randomized controlled study to evaluate the depigmenting activity of L-ascorbic acid plus phytic acid-serum vs. placebo on solar lentigines
Phytic acid · Journal of Cosmetic Dermatology, 2011Clinical Efficacy in Skin Hydration and Reducing Wrinkles of Nanoemulsions Containing Macadamia integrifolia Seed Oil
Macadamia seed oil · Nanomaterials, 2024Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin
Oil · Journal of Cosmetic Dermatology, 2020Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence
Zinc oxide · Biomedicines, 2025Lipid nanocarriers containing Passiflora edulis seeds oil intended for skin application
Passiflora edulis seed oil · Colloids and Surfaces. B, Biointerfaces, 2020Topical lycopene emulgel significantly improves biophysical parameters of human skin
Tomato extract · European Journal of Pharmaceutics and Biopharmaceutics, 2022Nanowire-based squalene oleogel repairs skin photoaging
Squalane · Journal of Nanobiotechnology, 2025Hydrolipidic Characteristics and Clinical Efficacy of a Dermocosmetic Formulation for the Improvement of Homeostasis on Oily Mature Skin
Medicago sativa extract · Life, 2022Evaluating pomegranate seed oil for potential topical applications: safety, anti-inflammatory activity and wound healing in skin cell models
Punica granatum seed oil · Inflammopharmacology, 2025Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials
Ascorbyl palmitate ascorbic acid · Frontiers in Pharmacology, 2025Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Panthenol, Vitamin b5, Vitamin b5 panthenol, Panthenol vitamin b5, Panthenol vb5, Pantothenic acid · Journal of Cosmetic Dermatology, 2025Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
Propanediol, Xylitol, Xylitylglucoside · Molecules, 2021Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid, Hydrolyzed sodium hyaluronate · Aesthetic Plastic Surgery, 2026Antioxidant and membrane-protective effects of the 3-O-ethyl ascorbic acid-cannabigerol system on UVB-irradiated human keratinocytes
3-o-ethyl ascorbic acid, 2-o-ethyl ascorbic acid, 3-o-ethyl-ascorbic acid · Free Radical Biology & Medicine, 2025The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013Efficacy and Safety of a New Cosmeceutical Regimen Based on the Combination of Snail Secretion Filtrate and Snail Egg Extract to Improve Signs of Skin Aging
Snail secretion filtrate, Sca · The Journal of Clinical and Aesthetic Dermatology, 2020Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer
Saccharomyces rice ferment filtrate, Saccharomyces ferment filtrate, Galactomyces ferment filtrate, Pitera ferment filtrate, Rice ferment filtrate sake ferment filtrate · Journal of Clinical Medicine, 2022Instrumental, clinical and subjective evaluation of the efficacy of a cosmetic treatment for home use
Acetyl glucosamine, Neoglucosamine · Journal of Cosmetic and Laser Therapy, 2019Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin
Vitamin e · Journal of Cosmetic Dermatology, 2024Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol
Caprylyl glycol, 2-hexanediol · Cutaneous and Ocular Toxicology, 2009The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites
Retinyl palmitate, Retinyl palmitate vitamin a, Retinol palmitate vitamin a · Journal of Cosmetic Dermatology, 2013Dually functionalized dendrimer for stimuli-responsive release of active ingredients into the skin
Palmitoyl pentapeptide-4 · Acta Biomaterialia, 2025Moisturizing effect of alcohol-based hand rub containing okra polysaccharide
Hibiscus esculentus fruit extract, Hydrolyzed hibiscus esculentus extract · International Journal of Cosmetic Science, 2012The Potential Role of Topically Applied Heparan Sulfate in the Treatment of Photodamage
Heparan sulfate · Journal of Drugs in Dermatology, 2015Preparation and characterization of astaxanthin-loaded biodegradable polyhydroxybutyrate (PHB) microbeads for personal care and cosmetic applications
Astaxanthin extract, Astaxanthin · International Journal of Biological Macromolecules, 2024Towards a modern approach to traditional use of Helichrysum italicum in dermatological conditions: In vivo testing supercritical extract on artificially irritated skin
Helichrysum italicum extract, Helichrysum italicum oil flower · Journal of Ethnopharmacology, 2023Standardized wild apple fruit extract as a bioactive agent in dermocosmetic products for efficacy skin hydration-In vitro and in vivo evaluation
Pyrus malus fruit extract · Journal of Cosmetic Dermatology, 2022Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects
Sodium ascorbyl phosphate · Experimental Dermatology, 2012Dead Sea minerals: New findings on skin and the biology beyond
Deep sea water · Experimental Dermatology, 2019Enzymatically interesterified fats based on mutton tallow and walnut oil suitable for cosmetic emulsions
Beef tallow, Grass-fed beef tallow · International Journal of Cosmetic Science, 2015Clinical efficacy of herbal extract cream on the skin hydration, elasticity, thickness, and dermis density for aged skin: A randomized controlled double-blind study
Botanical extracts · Journal of Cosmetic Dermatology, 2019The Role of miRNA167 in Skin Improvement: Insight from Extracellular Vesicles Derived from Rock Samphire (Crithmum maritimum)
Crithmum maritimum extract · Biomolecules, 2025Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects
Cucumis sativus fruit extract, Cucumis sativus cucumber fruit extract juice · International Journal of Biological Macromolecules, 2024Combining Topical and Oral Botanicals for Skin Redness, Pigmentation, Sleep, and Mood: A Randomized Controlled Study
Ashwagandha · Journal of Clinical Medicine, 2022Amended safety assessment of Sesamum indicum (sesame) seed oil, hydrogenated sesame seed oil, Sesamum indicum (sesame) oil unsaponifiables, and sodium sesameseedate
Sesamum indicum oil · International Journal of Toxicology, 2011Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides
Glucosyl ceramide · International Journal of Molecular Sciences, 2022A 10% Lactobionic acid-containing moisturizer reduces skin surface pH without irritation-An in vivo/in vitro study
Lactobionic acid · Journal of Cosmetic Dermatology, 2019Modulating effects of oatmeal extracts in the sodium lauryl sulfate skin irritancy model
Avena sativa kernel extract oat kernel extract · Skin Pharmacology and Applied Skin Physiology, 2002Salicin and Hederacoside C-Based Extracts and UV-Absorbers Co-Loaded into Bioactive Lipid Nanocarriers with Promoted Skin Antiaging and Hydrating Efficacy
Willow bark extract · Nanomaterials, 2022Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance
Hexylresorcinol · Archives of Dermatological Research, 2023Feasibility of Reflectance Confocal Microscopy Monitoring in Oily, Acne-Prone Facial Skin Treated with a Topical Combination of Alpha and Beta-Hydroxy Acids, Anti-Inflammatory Molecules, and Herculane Thermal Water: A Blinded, One-Month Study
Uriage thermal water · Life, 2022Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation
Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023Novel petrolatum-based ointment that is highly moisturizing and has superior usability with increased adherence in patients with facial dry skin
Oil · Journal of Cosmetic Dermatology, 2020Enhancing the Cosmetic Potential of Aloe Vera Gel by Kombucha-Mediated Fermentation: Phytochemical Analysis and Evaluation of Antioxidant, Anti-Aging and Moisturizing Properties
Saccharomyces xylinum black tea ferment · Molecules, 2025Biochemical Mechanism of Thai Fermented Soybean Extract on UVB-Induced Skin Keratinocyte Damage and Inflammation
Bean extract · International Journal of Molecular Sciences, 2025Moisturizing potentials of ascorbyl palmitate and calcium ascorbate in various topical formulations
Ascorbyl palmitate · International Journal of Cosmetic Science, 2004Retinol and Oligopeptide-Loaded Lipid Nanocarriers as Effective Raw Material in Anti-Acne and Anti-Aging Therapies
Oligopeptides · Life, 2024Lotus Sprout Extract Induces Selective Melanosomal Autophagy and Reduces Pigmentation
Nelumbo nucifera extract · Journal of Cosmetic Dermatology, 2025New targets in the battle against dandruff
Epilobium angustifolium extract · Journal of Cosmetic Science, 2017Formulation and evaluation of exotic fat based cosmeceuticals for skin repair
Mangifera indica seed butter, Mangifera indica seed oil · Indian Journal of Pharmaceutical Sciences, 2008Specific protection of sensitive skin against environmental stress by maintenance and improvement of barrier function
Aquaphilus dolomiae extract filtrate · Journal of the European Academy of Dermatology and Venereology, 2022Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
Caprylic capric triglyceride, Capric triglyceride, Triglycerides · Life, 2023The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study
3 essential ceramides · Journal of Cosmetic Dermatology, 2025Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy
Tocopheryl acetate vitamin e, Tocopheryl acetate, Vitamin e tocopheryl acetate · Scientific Reports, 2025Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence
Adenosine · International Journal of Molecular Sciences, 2026Development and efficacy assessments of tea seed oil makeup remover
Camellia sinensis seed oil, Camellia oleifera seed oil, Camellia seed oil · Annales Pharmaceutiques Francaises, 2017Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery
Hydrolyzed hyaluronic acid, Hydrolyzed sodium hyaluronate · Colloids and Surfaces. B, Biointerfaces, 2022Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome
Lactobacillus ferment · Clinical, Cosmetic and Investigational Dermatology, 2023Protective properties of Avène Thermal Spring Water on biomechanical, ultrastructural and clinical parameters of human skin
Thermal spring water, Prebiotic thermal water · Journal of the European Academy of Dermatology and Venereology, 2020Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging
Tetrahexyldecyl ascorbate, Ascorbyl tetraisopalmitate, Tetrahexydecyl ascorbate · Journal of Cosmetic Dermatology, 2024Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study
Hydrolyzed jojoba esters, Jojoba esters, Jojoba · Journal of Cosmetic Dermatology, 2008Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients
3-o-ethyl ascorbic acid, 2-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026Poly-γ-Glutamic Acid from a Novel Bacillus subtilis Strain: Strengthening the Skin Barrier and Improving Moisture Retention in Keratinocytes and a Reconstructed Skin Model
Polyglutamic acid · International Journal of Molecular Sciences, 2025Functional properties and skin care effects of sodium trehalose sulfate
Trehalose · Skin Research and Technology, 2024Clinical efficacy of facial masks containing yoghurt and Opuntia humifusa Raf. (F-YOP)
Yogurt · Journal of Cosmetic Science, 2011Investigating the protective effect of Rosa damascena nanogel on collagenase and elastase activity and UVB-induced dermal damage: A rodent model approach to skin photoaging
Rosa damascena flower extract · Photochemistry and Photobiology, 2025Clinical study of a spray containing birch juice for repairing sensitive skin
Betula alba juice · Archives of Dermatological Research, 2023Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes
Artemisia princeps leaf extract · Molecular Medicine Reports, 2017A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females
Ascorbyl glucoside, L-ascorbic acid 2-glucoside · Journal of Drugs in Dermatology, 2016Liposomal formulation of a vitamin C derivative: a promising strategy to increase skin permeability
2-o-ethyl ascorbic acid, 3-o-ethyl ascorbic acid · Journal of Liposome Research, 2025Hippophae rhamnoides oil-in-water (O/W) emulsion improves barrier function in healthy human subjects
Hippophae rhamnoides, Hippophae rhamnoides oil, Hippophae rhamnoides oil fruit, Hippophae rhamnoides seed oil · Pakistan Journal of Pharmaceutical Sciences, 2014Chitosan derivative nanocarrier: safety evaluation,antibacterial property and ascorbyl palmitate encapsulation
Ascorbyl palmitate · Journal of Microencapsulation, 2010Modulation of cellular senescence in fibroblasts and dermal papillae cells in vitro
Hexapeptide-11 · Journal of Cosmetic Science, 2013Peptide-pro complex serum: Investigating effects on aged skin
Marine extracts · Journal of Cosmetic Dermatology, 2023The effect of a synthetic ceramide-2 on transepidermal water loss after stripping or sodium lauryl sulfate treatment: an in vivo study
Ceramide 2 · International Journal of Cosmetic Science, 1997Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris
Capryloyl salicylic acid, Citric acid · Journal of Drugs in Dermatology, 2013A method for maintaining the clinical results of 4% hydroquinone and 0.025% tretinoin with a cosmeceutical formulation
Yeast extract · Journal of Drugs in Dermatology, 2015Sodium hydroxide-induced subclinical irritation. A test for evaluating stratum corneum barrier function
Sodium hydroxide · Acta Dermato-venereologica, 1990The influence of low concentrations of irritants on skin barrier function as determined by water vapour loss
Sodium hydroxide · Dermatosen in Beruf und Umwelt. Occupation and Environment, 1985Treatment of Stretch Marks Using a New Formulation Combining Nanofractional Radiofrequency Plus Magnetic Nanofractional Radiofrequency
Beta-glucan · Dermatology and Therapy, 2023Preliminary safety and in vivo efficacy of Acmella oleracea extract-loaded glycolipid emulsion serum-Effects on ocular irritation, dermal absorption, and facial skin biophysical and microrelief properties
Glycolipids, Acmella oleracea extract · International Journal of Cosmetic Science, 2025Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser: A prospective randomized vehicle-controlled parallel group study
Beta-glucan · The Journal of Dermatology, 2022Hydrating effects of a corticoid oil formulation and its vehicle on human skin
Arachis hypogaea oil · Skin Pharmacology and Applied Skin Physiology, 2003Protective effects of Paeonia suffruticosa callus extract in skin through anti-inflammation and repair UVB-induced damage
Paeonia suffruticosa branch leaf extract flower · International Journal of Cosmetic Science, 2025Glycerol crosslinked vitamin E loaded xanthan gum and gellan gum nanoemulgels for topical management of dry skin
Xanthan gum · International Journal of Biological Macromolecules, 2025Histometric assessment of the age-related skin response to 2-hydroxy-5-octanoyl benzoic acid
Capryloyl salicylic acid · Skin Pharmacology and Applied Skin Physiology, 1998Investigation of Controlled Release Molecular Mechanism of Oil Phase in Spilanthol Emulsion: Development and In Vitro, In Vivo Characterization
Spilanthes acmella flower extract · AAPS PharmSciTech, 2019Improvement of urban eye skin in Chinese female by supramolecular retinol plus acmella oleracea extract-containing product
Acmella oleracea extract · Journal of Cosmetic Dermatology, 2022Beneficial modulation from a high-purity caviar-derived homogenate on chronological skin aging
Caviar extract · Rejuvenation Research, 2012Transdermal Delivery of Baicalin Based on Bio-Vesicles and Its Efficacy in Antiaging of the Skin
Scutellaria baicalensis root extract · Journal of Cosmetic Dermatology, 2025κ-Carrageenan tetrasaccharide ameliorates particulate matter-induced defects in skin hydration of human keratinocytes cells and skin barrier disorders
Gigartina skottsbergii extract · International Journal of Biological Macromolecules, 2025Macrocystis pyrifera ferment-containing creams for optimizing facial skin rejuvenation
Macrocystis pyrifera extract · Journal of Cosmetic Dermatology, 2023Protection of the flowers of Prunus persica extract from ultraviolet B-induced damage of normal human keratinocytes
Prunus persica extract · Archives of Pharmacal Research, 2000Influence of the emulsifier on nanostructure and clinical application of liquid crystalline emulsions
Camellia seed oil · Scientific Reports, 2023Composition characterization and clinical efficacy study of a salmon egg extract
Salmon egg extract · International Journal of Cosmetic Science, 2013In vitro, ex vivo and clinical approaches to evaluate the potential effect of Gentiana lutea extract on skin
Gentiana lutea extract · International Journal of Cosmetic Science, 2023Clinical evaluation of anaesthetic-like effect of two dermocosmetic formulations containing Aquaphilus dolomiae extract-G3 in subjects with sensitive facial skin
Aquaphilus dolomiae extract filtrate · Journal of the European Academy of Dermatology and Venereology, 2022The Real-World Effectiveness and Tolerability of a Soothing Cream Containing the Postbiotic Aquaphilus dolomiae Extract-G2 for Skin Healing
Aquaphilus dolomiae extract filtrate · Dermatology and Therapy, 2024Effects of a grapeseed oil (Vitis vinifera L.) loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin: A split-face, blinded, placebo-controlled study
Naturally sourced grapeseed oil · Journal of Cosmetic Dermatology, 2022Photoprotective, Antioxidant and Anti-Inflammatory Effects of Aged Punica granatum Extract: In Vitro and In Vivo Insights
Punica granatum extract · Food Science & Nutrition, 2025Effects of fermented tea seed oil on the skin lipid barrier and microbiome of sensitive skin
Camellia sinensis seed oil, Camellia oleifera seed oil, Camellia seed oil · International Journal of Cosmetic Science, 2026Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate vitamin e, Tocopheryl acetate, Vitamin e tocopheryl acetate · Contemporary Clinical Trials Communications, 2021Effects of Malaysian thermal spring water as adjunct therapy for mild to moderate acne vulgaris - a prospective, randomised, controlled, split face study
Thermal spring water, Thermal water, Thermal biotic complex, Avène thermal spring water, Mineral-rich water, Prebiotic thermal water · The Medical Journal of Malaysia, 2024Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora
Paeonia albiflora root extract, Sodium dna · International Journal of Molecular Sciences, 2025Impact of Hydrocolloid Dressing and Moisturizing Cream as Facial Skin Protectants Among Health Care Workers
Dimethicone · Military Medicine, 2024Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling
Portulaca extract, Portulaca oleracea extract, Purslane extract, Lactobacillus portulaca oleracea extract ferment · Cutaneous and Ocular Toxicology, 2022Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A randomized placebo-controlled study
Snail secretion filtrate, Snail secretion filtrate sca growth factor technology filtrate · Journal of Cosmetic Dermatology, 2022Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months-An 11-Year Longitudinal Skin Aging Rejuvenation Study
Saccharomyces rice ferment filtrate, Galactomyces ferment filtrate, Saccharomyces ferment filtrate, Pitera ferment filtrate, Rice ferment filtrate sake ferment filtrate · Journal of Clinical Medicine, 2023The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study
Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos
Arginine, Ascorbyl glucoside · International Journal of Molecular Sciences, 2024Pleiotropic effects of a Camellia sinensis leaf extract on in vitro and in vivo skin health characteristics
Camellia sinensis leaf water · International Journal of Cosmetic Science, 2025Potassium 4-Methoxysalicylate (4MSK) Exerts a Skin Lightening Effect by Acting on Melanocytes and Keratinocytes
Potassium methoxysalicylate · Journal of Cosmetic Dermatology, 2025New Chalcone-Derived Molecule for the Topical Regulation of Hyperpigmentation and Skin Aging
Angelica keiskei leaf extract · Pharmaceutics, 2024A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties
Bakuchiol · Skin Research and Technology, 2026Evolution of lipid composition in skin treated with blackcurrant seed oil
Ribes nigrum seed oil · International Journal of Cosmetic Science, 1988Investigating the Effects of a Manuka Honey, Royal Jelly, and Bee Venom-Derived Face Serum on Skin Health and Signs of Aging
Royal jelly extract, Royal jelly · Cureus, 2025Clinical Assessment of a Novel Jasmonate Cosmeceutical, LR2412-Cx, for the Treatment of Skin Aging
Jasmonic acid · Journal of Drugs in Dermatology, 2016Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study
Zinc gluconate · Journal of Cosmetic Dermatology, 2026The clinical efficacy of a new emulsion for acne and conspicuous facial pore amelioration
Lens esculenta seed extract · Journal of Cosmetic Dermatology, 2024Mitigation of ultraviolet-induced erythema and inflammation by para-hydroxycinnamic acid in human skin
Ethylhexyl methoxycinnamate · International Journal of Cosmetic Science, 2025Facial disbiosis and UV filters
Ethylhexyl methoxycinnamate · Archives of Dermatological Research, 2024Darutoside promotes skin wound healing via regulating macrophage polarization
Sigesbeckia orientalis extract · Molecular Immunology, 2025[Topical application of vitamins, phytosterols and ceramides. Protection against increased expression of interstital collagenase and reduced collagen-I expression after single exposure to UVA irradiation]
Phytosterols · Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, und Verwandte Gebiete, 2008Biotransformed soybean cream as a new nutraceutical for skin care: collagen stimulation in vitro and ex vivo
Bean extract · Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas E Biologicas, 2023Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits
Palmitoyl hexapeptide-12 · ACS Applied Bio Materials, 2025A cleanser formulated with Tris (hydroxymethyl) aminomethane and l-arginine significantly improves facial acne in male Thai subjects
Arginine · Journal of Cosmetic Dermatology, 2020Interaction of Liposomes Containing the Carrageenan/Echinochrome Complex with Human HaCaT Keratinocytes In Vitro
Gigartina skottsbergii extract · Marine Drugs, 2024Real-world experience with a treatment with a skincare regimen of products containing the Macrocystis pyrifera ferment for optimizing facial skin rejuvenation
Macrocystis pyrifera extract · Journal of Cosmetic Dermatology, 2024Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging
Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025Open-label topical application of tetrahexyldecyl ascorbate and acetyl zingerone containing serum improves the appearance of photoaging and uneven pigmentation
Ascorbic acid tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing
Pro-retinol, Hexylresorcinol, Retinyl propionate · International Journal of Cosmetic Science, 2024Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial
Shea butter, Saccharide isomerate, Argania spinosa kernel oil, Butyrospermum parkii butter shea butter, African shea butter, Argania spinosa kernel oil argan kernel oil, Argan oil, Butyrospermum parkii butter, Butyrospermum parkii butter extract shea butter extract, Shea extract, Shea nut butter · Lasers in Medical Science, 2025Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters
Gluconolactone · Skin Research and Technology, 2023A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study
Saccharide isomerate · The Journal of Dermatological Treatment, 2025Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis
Palmitoyl pentapeptide-4, Triple peptide · Cureus, 2026Saccharide isomerate ameliorates cosmetic scalp conditions in a Chinese study population
Saccharide isomerate · Journal of Cosmetic Dermatology, 2023Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism
Palmitoyl tripeptide-1, Palmitoyl oligopeptide, Tripeptide-1, 9 signal peptides · Journal of Cosmetic Dermatology, 2026Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking
Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1, Matrixyl 3000 · International Journal of Cosmetic Science, 2026Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial
Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin
Portulaca extract, Portulaca oleracea extract, Purslane extract, Lactobacillus portulaca oleracea extract ferment · Cutaneous and Ocular Toxicology, 2025Synergistic combination: Developing a natural carrier-free assembled gel through hydrogen bond reconstruction strategy for efficient skin photo-damage restoration
Sodium pca · Biomaterials Advances, 2026Simmondsia chinensis (jojoba) cake fermentation: A new, sustainable technology for advanced skin and scalp care ingredients
Lactobacillus ferment · International Journal of Cosmetic Science, 2026Effects of a Greek Yoghurt-based Complex on the Human Facial Skin Microbiome
Yogurt · In Vivo, 2026From Plant to Nano-Clinic: Advancing Wound Healing with Nano- Encapsulated Rosa damascena Callus Extract
Rosa damascena flower extract · Pharmaceutical Nanotechnology, 2026Structure/property comparisons of chemistries based on renewable 1,3-propanediol and petroleum-derived alkylene oxides
Propanediol · Journal of Cosmetic Science, 2017Efficacy of anti-sebum moisturizing cream containing 2% l-carnitine and 5% epigallocatechin gallate in seborrhea: A randomized clinical trial
Camellia sinensis leaf water, Uji green tea extract · Journal of Cosmetic Dermatology, 2023Evaluation of molecules or extracts modulating seborrhea and its consequences, using normal human culture of sebocytes and keratinocytes, skin explants models and in vivo methods: a case study
Syringa vulgaris cells stem · Journal of Cosmetic Science, 2017Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population
Bakuchiol, Bio-retinol, Terminalia chebula fruit extract · Health Science Reports, 2025Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin
5-ceramide complex, Ceramide iii · Skin Pharmacology and Physiology, 2026Dermatological Effects of a Beeswax-Pine Resin Mixture on Abdominal Skin: A Proof-of-Concept Study Supporting the Development of an Affordable Investigational Ostomy Pouching System in Low-Income Regions
Beeswax cera alba cera, Beeswax · Journal of Wound, Ostomy, and Continence Nursing, 2026Two new lipoaminoacids with complementary modes of action: new prospects to fight out against skin aging
Palmitoyl glycine · International Journal of Cosmetic Science, 2010The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies
Laminaria digitata extract, Dipeptide diaminobutyroyl benzylamide diacetate · International Journal of Cosmetic Science, 2026Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial
Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025The harnessing potential of carboxymethyl beta glucan: A driver of skin repair
Sodium carboxymethyl beta-glucan · International Journal of Cosmetic Science, 2026The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color
Galactomyces ferment filtrate, Saccharomyces ferment filtrate · Skinmed, 2021Development, characterization, and clinical investigation of Spinacia oleracea-based ultra-high pressure homogenized emulsion system for facial physiological parameters
Spinach · Journal of Cosmetic Dermatology, 2022Fruit acids and sodium hydroxide in the food industry and their combined effect with sodium lauryl sulphate: controlled in vivo tandem irritation study
Sodium hydroxide · The British Journal of Dermatology, 2004Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu
Copper tripeptide-1, Tripeptide-1, 9 signal peptides · Skin Research and Technology, 2026Investigation of water-soluble elastin as a multifunctional cosmetic material: Moisturizing and whitening effects
Hydrolyzed elastin · Journal of Cosmetic Science, 2017Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis
Mushroom extract · Frontiers in Nutrition, 2026Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial
Ascorbyl glucoside · Cureus, 2026Preclinical Safety Evaluation of Dual Drug-Loaded Nanolipidic Carriers of Dissolvable Patches: In-Vitro and In-Vivo Safety Assessment
Tetrahydrodiferuloylmethane · Molecular Pharmaceutics, 2025The Application of a Formulation Containing Hydroxypropyl Tetrahydropyrantriol and Niacinamide to Augment Anti-aging Benefits in a Double-blind, Randomized Nonablative Laser Treatment Study
Hydroxypropyl tetrahydropyrantriol · The Journal of Clinical and Aesthetic Dermatology, 2025Acetyl Dipeptide-31 Amide: A Novel Cosmetic Anti-Inflammatory Peptide That Demonstrates Anti-Aging, Firming, and Lifting Benefits
Acetyl dipeptide-31 amide · Journal of Drugs in Dermatology, 2025A Single-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of the Effectiveness of ANT1 Soybean Extract Cream on Skin Recovery After Nd: YAG Laser Treatment
Bean extract · Annals of Plastic Surgery, 2018Phytochemical characterization and antidermatophytic activity of a leaf extract from Mitracarpusscaber
Mitracarpus scaber extract · Journal of Ethnopharmacology, 2026Natural Moisturizing Factor-Enriched Formulations Compared to a Ceramide-Based Cream
Moisturizing factors, Hydration complex · Journal of Drugs in Dermatology, 2024A Topical Formulation Containing Macrocystis Pyrifera Ferment for Managing Barrier Damage After Mild-Moderate Skin Disruption from Cosmetic Dermatologic Procedures
Macrocystis pyrifera extract · The Journal of Clinical and Aesthetic Dermatology, 2025Nelumbo nucifera extract alleviates UVB-induced hyperpigmentation via NOX4-mediated AMPK-YAP-ATG5 signaling pathway
Multi-action super lotus · Phytomedicine, 2026Clinical Evaluation of a Soap-Free Cleansing Lotion Containing Sodium Cocoyl Apple Amino Acids for Effective Impurity Removal and Skin Barrier Preservation in Healthy Adults With Diverse Skin Types
Cetyl alcohol · Cureus, 2025Human skin equivalents are an excellent tool to study the effect of moisturizers on the water distribution in the stratum corneum
Isopropyl isostearate · International Journal of Cosmetic Science, 2012Safety Assessment of Caprylhydroxamic Acid as Used in Cosmetics
Caprylhydroxamic acid · International Journal of Toxicology, 2025