Shiseido Urban Environment Oil-Free UV Protector SPF 42 for sensitive skin

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Questions and answers

What the research says

• Sodium trehalose sulfate decreased transepidermal water loss and increased stratum corneum water content in participants with low stratum corneum water content when applied for 4 weeks compared to placebo.

  Skin Research and Technology, 2024

• Liposomal encapsulation of octyl methoxycinnamate increases its safety, skin affinity, and in vivo solar photoprotection factor while slowing its release and enhancing retention in the stratum corneum compared to a conventional formulation.

  International Journal of Nanomedicine, 2013

• Multilamellar liposomes containing octyl methoxycinnamate increased stratum corneum accumulation and reduced deeper skin penetration compared to conventional emulsions and small unilamellar liposomes in six volunteers, resulting in a slightly better sun protection factor.

  Journal of Cosmetic Science, 2008

• The application of a sunscreen formulation containing ethylhexyl methoxycinnamate, ethylhexyl salicylate, methyl anthranilate, and octocrylene does not significantly affect critical acne-related species such as Cutibacterium acnes and Staphylococcus epidermidis, refuting the induction of facial dysbiosis in men.

  Archives of Dermatological Research, 2024

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical 0.5% hyaluronic-ZnO nanogel applied twice daily reduced inflammatory-lesion counts by 58% at week four in human subjects compared to baseline without causing erythema.

  Biomedicines, 2025

• Nels cream achieved a similar reduction in inflammatory and noninflammatory lesion counts compared to 5% benzoyl peroxide in acne vulgaris patients, but caused significantly fewer side-effects such as peeling and dryness.

  Clinical and Experimental Dermatology, 2000

• Topically applied coated and uncoated zinc oxide nanoparticles under flexing and massage are retained in the stratum corneum with no significant penetration into the viable epidermis and no cellular toxicity in human skin.

  Nanomedicine, 2016

• Replacing 20% of the chemical UV filter octyl methoxycinnamate with urucum oil in solid lipid nanoparticles maintained the skin protection factor without inducing toxic responses or significant skin penetration in human volunteers.

  Skin Pharmacology and Physiology, 2018

• Encapsulation of ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane in lipid microparticles significantly reduced their in vivo human skin penetration compared to nonencapsulated filters.

  Skin Pharmacology and Physiology, 2011

• The difference in dermatotoxicokinetic parameters between trans-EHMC and cis-EHMC isomers was not statistically significant when applied to the forearm skin of two volunteers.

  Environmental Science and Pollution Research International, 2017

• Incorporating rosmarinic acid into sunscreens enhanced the in vivo SPF of octocrylene by over 157% and reduced lipid peroxidation in the human stratum corneum.

  Antioxidants, 2025

• Early application of sunscreen after ablative fractional skin resurfacing significantly increased the sensitization rate of the UV-filter, octocrylene, and the sunscreen compared to intact skin.

  The Journal of Dermatological Treatment, 2015

• Dermal sunscreen exposure in 20 healthy volunteers led to plasma concentrations of avobenzone, octocrylene, and its metabolite CDAA reaching up to 11 μg/L, 25 μg/L, and 1352 μg/L, respectively.

  Environment International, 2019

• Motor baicalin encapsulated in bio-vesicles enhanced water solubility, stability, transdermal penetration, antioxidant activity, and clinical skin antiaging efficacy compared to liposome baicalin and baicalin raw material.

  Journal of Cosmetic Dermatology, 2025

• A nighttime topical antioxidant containing resveratrol, baicalin, and vitamin E significantly improved fine lines, wrinkles, firmness, elasticity, laxity, hyperpigmentation, radiance, roughness, and dermal thickness in subjects with mild to moderately photodamaged skin over 12 weeks.

  Journal of Drugs in Dermatology, 2014

• Glycyrrhizin micellar nanocarriers significantly improved topical penetration and follicular accumulation of baicalin in porcine skin, enhanced human dermal papilla cell proliferation, and promoted hair recovery through Wnt/β-catenin pathway activation and upregulation of VEGF, α-MSH, and IL-10.

  International Journal of Pharmaceutics, 2022

Ingredients

Sodium Hyaluronate, Spirulina Energy Essence, Ensulizole, Homosalate, Octisalate, Zinc Oxide, Water, Dimethicone, Trisiloxane, Sd Alcohol 40-B, Glycerin, Silica, Peg Ppg-14 7 Dimethyl Ether, Lauryl Peg-9 Polydimethylsiloxyethyl Dimethicone, Peg-10 Dimethicone, Trehalose, Myristyl Myristate, Ethylhexyl Palmitate, Dextrin Palmitate, Isodecyl Neopentanoate, Ascorbyl Tetraisopalmitate, Thiotaurine, Dipotassium Glycyrrhizate, Scutellaria Baicalensis Root Extract, Paeonia Albiflora Root Extract, Sanguisorba Officinalis Root Extract, Camellia Sinensis Leaf Extract, Garcinia Mangostana Bark Extract, Perilla Ocymoides Leaf Extract, Spirulina Platensis Extract, Triethanolamine, Triethoxycaprylylsilane, Butylene Glycol, Disodium Edta, Disteardimonium Hectorite, Tocopherol, Bht, Alcohol, Isostearic Acid, Menthoxypropanediol, Sodium Metabisulfite, Polysilicone-2, Barium Sulfate, Sodium Citrate, Phenoxyethanol, Benzoic Acid, Iron Oxides

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.