Shiseido Ultimune Power Infusing Concentrate for combination skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Sodium trehalose sulfate decreased transepidermal water loss and increased stratum corneum water content in participants with low stratum corneum water content when applied for 4 weeks compared to placebo.

  Skin Research and Technology, 2024

• Treatment with a rose extract activated newly identified skin olfactory receptors and prevented epinephrine-induced skin stress responses in epidermal keratinocytes and human skin explants, while clinically decreasing the appearance of under-eye dark circles in stressed women.

  Molecules, 2020

• Rose petal extract improves stratum corneum moisture levels in humans by upregulating HAS2 expression via the GLK-MAP2K-MAPK signaling pathway.

  BioFactors, 2023

• Rosa gallica petal extract (RPE) exerts skin whitening by attenuating tyrosinase activity and melanin accumulation and exhibits anti-wrinkle activity by suppressing MMP-1 levels in human cells.

  Journal of Medicinal Food, 2020

• Topical application of a 2% cream containing combined fruit extracts for 56 days significantly reduced wrinkle depth by 11.5%, length by 10.07%, and area by 29.55% in 21 female subjects compared to a placebo.

  Clinical, Cosmetic and Investigational Dermatology, 2015

• A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris.

  Clinical, Cosmetic and Investigational Dermatology, 2015

• Topical application of Ginkgo biloba cream for two weeks reduced wrinkles and improved skin shape, texture, and tautness in human volunteers compared to baseline.

  Drug Development and Industrial Pharmacy, 2023

• Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

  Journal of Cosmetic Dermatology, 2025

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

  Journal of Cosmetic Dermatology, 2024

• Topical application of soap enriched with Ganoderma lucidum and goat's milk for 3 days resulted in almost complete regression of annular cutaneous sarcoidosis lesions in a 44-year-old male patient.

  Dermatology and Therapy, 2016

• Ganoderma lucidum polysaccharides at concentrations of 10, 20, and 40 ΓΖg/mL significantly increased fibroblast viability, migration, and CICP and TGF-Β1 expression compared to the control group, and external use in mice significantly increased wound healing rates and reduced healing time.

  Chinese Journal of Integrative Medicine, 2019

• Ethanolic extracts of Ganoderma lucidum rich in triterpenoids and phenolic acids exhibit antioxidant, anti-inflammatory, antityrosinase, antimicrobial, and cytotoxic effects, and can be successfully incorporated into topical cosmeceutical formulations while preserving their bioactivities.

  Food and Chemical Toxicology, 2017

Why other serums fit combination skin better

• Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.

  BioMed Research International, 2022

• A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.

  Journal of Cosmetic Dermatology, 2024

Ingredients

Water, Alcohol Denat, Glycerin, Butylene Glycol, Dimethicone, Diglycerin, Peg Ppg-17 4 Dimethyl Ether, Phenoxyethanol, Triethylhexanoin, Isodecyl Neopentanoate, Trehalose, Ammonium Acryloyldimethyltaurate Beheneth-25 Methacrylate Crosspolymer, Peg-14m, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Peg Ppg-14 7 Dimethyl Ether, Tocopheryl Acetate, Rosa Damascena Flower Water, Parfum, Disodium Edta, Potassium Hydroxide, Silica, Isoceteth-10, Linalool, Lauryl Betaine, Ginkgo Biloba Leaf Extract, Geraniol, Citronellol, Origanum Majorana Leaf Extract, Nelumbo Nucifera Germ Extract, Sodium Carboxymethyl Beta-Glucan, Bht, Thymus Serpyllum Extract, Perilla Ocymoides Leaf Extract, Sodium Bicarbonate, Iris Florentina Root Extract, Sodium Benzoate, Ganoderma Lucidum Stem Extract Mushroom Stem Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.