🇬🇧United Kingdom

iS Clinical skincare

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

iS Clinical is an American skincare brand founded in 2000 and owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Botanical serums, rich moisturizers, gentle cleansers, and targeted eye products have earned iS Clinical a devoted following for their sophisticated formulations. Its products suit oily skin and sensitive skin best, thanks to the balanced nature of these botanical blends. For specific concerns, the Cleansing Complex addresses acne-prone skin, the Super Serum Advance+ targets dark spots, and the Youth Eye Complex is favored for mature skin. Together, these thoughtful preparations deliver reliable results while maintaining skin comfort.

This page covers some of the most popular iS Clinical products; for the whole iS Clinical range, with a fit score for every product, use the Lovi app.

Other iS Clinical products

People Say

★4.7Overall rating based on 4.4k+ reviews

Reviewers most often praise iS Clinical for gentle hydration, effective acne management, and lightweight textures. The most common complaints are high price points and insufficient hydration for dry skin.

Highlights

  • Lightweight, non-greasy moisturizers Mostly Mentioned
    • “Absorbs beautifully — Reparative Moisture Emulsion”
    • “Drink of water — Hydra-Cool Serum”
  • Texture-improving serums Mostly Mentioned
    • “skin feels softer — Active Serum”
    • “Fades acne scars — Super Serum Advance+”
  • Anti-aging serums Often Mentioned
    • “Reduces fine lines — Super Serum Advance+”
    • “softens fine lines — Active Serum”
  • Non-irritating serums Often Mentioned
    • “Good for sensitive skin — Super Serum Advance+”
    • “It is not oily or pore clogging and hasn't irritated my acne prone skin. — Brightening Complex”
  • High price point Mostly Mentioned
    • “expensive for small bottle — Active Serum”
    • “Definitely pricey — Reparative Moisture Emulsion”
    • “Just expensive — Hydra-Cool Serum”

Sources: lovi.care, dermstore.com, lovelyskin.com, bluemercury.com, spacenk.com, walmart.com, and more

Questions and answers

Is iS Clinical good for oily skin?

Yes, iS Clinical fits oily skin well, as Lovi rates the brand-focused routine Superior for this skin type. The iS Clinical products on this page are fragrance-free and include lightweight, non-greasy moisturizers alongside texture-improving serums.

Is iS Clinical worth it?

Yes, iS Clinical is worth it for shoppers seeking lightweight moisturizers and texture-improving serums, though reviewers note a high price point. Lovi rates the brand-focused routines Superior for oily, sensitive, and acne-prone skin, and Superior for dry skin. The iS Clinical products on this page are fragrance-free.

What are iS Clinical's best products?

iS Clinical's best products are Youth Eye Complex and Cleansing Complex, as Lovi rates them Superior for mature skin and oily or sensitive skin. Reviewers frequently mention that the brand offers texture-improving and anti-aging serums alongside lightweight, non-greasy moisturizers.

Which iS Clinical moisturizer is best for dry skin?

Hydra-Cool Serum is the best iS Clinical moisturizer for dry skin, and Reparative Moisture Emulsion is also a good option.

Does iS Clinical cause breakouts?

iS Clinical is unlikely to cause breakouts, as the brand features non-irritating serums and lightweight, non-greasy moisturizers. Lovi rates acne-prone skin as a Superior fit for the brand-focused routine.

Is iS Clinical fragrance-free?

Yes, every product from the iS Clinical products on this page lists no fragrance in its ingredients. Reviewers mostly mention that these items are lightweight and non-greasy.

What are the key ingredients in iS Clinical products?

The key ingredient in the iS Clinical products on this page is hyaluronic acid. Topical application of hyaluronic acid helps improve skin quality and signs of skin aging.

Dermatologic Therapy, 2022

How do I build a iS Clinical skincare routine?

To build an iS Clinical routine for dry skin, start your morning with Cleansing Complex, Hydra-Cool Serum, and sunscreen, while your evening routine adds Super Serum Advance+ alongside the cleanser and serum. Once a week, include Vita Essential Mask in your routine to nourish dry skin.

Dermatologic Therapy, 2022Journal of Cosmetic Dermatology, 2020

Where can I buy iS Clinical, and how much does it cost?

You can buy iS Clinical at stores in the United Kingdom shown on this page. Prices range from £44.00 to £113.00, with most products costing between £87.00 and £98.00.

What are good alternatives to iS Clinical?

Good alternatives to iS Clinical with similar brand pages on Lovi include CeraVe, Cetaphil, Paula's Choice, Neutrogena, Kiehl's, and Dermalogica. These brands offer alternative options for various skin types and routines.

iS Clinical vs CeraVe: which is better?

iS Clinical and CeraVe tie for combination skin and acne-prone skin with Superior fits, and CeraVe takes the lead for combination skin, while iS Clinical rates Superior for dry skin compared to CeraVe's High fit. Both brands rate Superior for oily skin and sensitive skin.

Who owns iS Clinical, and where is it from?

iS Clinical is an American brand founded in 2000, owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Is iS Clinical cruelty-free?

PETA, Leaping Bunny, and Cruelty Free International, the registries Lovi checks, do not list iS Clinical as cruelty-free.

Is iS Clinical good for dry skin?

iS Clinical is a good choice for dry skin, and Lovi rates the iS Clinical-focused routine Superior for this skin type. The iS Clinical products on this page feature hydrating ingredients like hyaluronic acid, which helps smooth and soften dry skin. Reviewers often mention that the brand's moisturizers feel lightweight and non-greasy.

Dermatologic Therapy, 2022

Which iS Clinical cleanser is best for oily skin?

Cleansing Complex is the best cleanser on this page for oily skin, where Lovi rates it Superior.

Is iS Clinical good for sensitive skin?

Yes, iS Clinical fits sensitive skin well because Lovi rates the brand-focused routine Superior for it and reviewers often find the serums non-irritating. Lovi rates Cleansing Complex and Youth Eye Complex Superior for sensitive skin, while Active Serum rates Average. The iS Clinical products on this page list no fragrance in their ingredients.

Is iS Clinical good for acne-prone skin?

Yes, iS Clinical is a great fit for acne-prone skin, with Lovi rating its brand-focused routine Superior for this skin type. Reviewers often mention its texture-improving serums, and the iS Clinical products on this page list no fragrance.

Is iS Clinical good for skin with dark spots?

iS Clinical is a good choice for skin with dark spots because several of its serums and moisturizers, such as Super Serum Advance+ and Brightening Complex, help improve uneven skin tone. Lovi rates Cleansing Complex, Active Serum, Hydra-Cool Serum, Super Serum Advance+, and Youth Eye Complex High for skin with dark spots. Reviewers often mention that the brand's texture-improving serums leave skin looking clearer.

Journal of Cosmetic Dermatology, 2020Journal of Cosmetic Dermatology, 2020

Is iS Clinical good for mature skin?

iS Clinical is a good choice for mature skin, and Lovi rates Youth Eye Complex Superior and Reparative Moisture Emulsion High for this skin type. Reviewers often mention the anti-aging serums, which help smooth the look of lines.

Dermatologic Therapy, 2022

Research behind iS Clinical's key ingredients

Behind these ratings

Lovi rates every product from its full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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