🇮🇹Italy

iS Clinical skincare

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

iS Clinical is an American skincare brand founded in 2000 and owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Skincare enthusiasts love iS Clinical for its expertly formulated serums, moisturizers, cleansers, and eye products. Its products suit dry skin and acne-prone skin best due to the targeted nature of its active formulas. For particular concerns, the standout products include the Cleansing Complex for acne-prone skin, the Super Serum Advance+ for skin with dark spots, and the Youth Eye Complex for mature skin. Through thoughtful design, the brand delivers reliable results without relying on complex jargon.

This page covers some of the most popular iS Clinical products; for the whole iS Clinical range, with a fit score for every product, use the Lovi app.

Other iS Clinical products

People Say

★4.7Overall rating based on 4.4k+ reviews

Reviewers most often praise iS Clinical for gentle hydration, effective acne management, and lightweight textures. The most common complaints are high price points and insufficient hydration for dry skin.

Highlights

  • Lightweight, non-greasy moisturizers Mostly Mentioned
    • “Absorbs beautifully — Reparative Moisture Emulsion”
    • “Drink of water — Hydra-Cool Serum”
  • Texture-improving serums Mostly Mentioned
    • “skin feels softer — Active Serum”
    • “Fades acne scars — Super Serum Advance+”
  • Anti-aging serums Often Mentioned
    • “Reduces fine lines — Super Serum Advance+”
    • “softens fine lines — Active Serum”
  • Non-irritating serums Often Mentioned
    • “Good for sensitive skin — Super Serum Advance+”
    • “It is not oily or pore clogging and hasn't irritated my acne prone skin. — Brightening Complex”
  • High price point Mostly Mentioned
    • “expensive for small bottle — Active Serum”
    • “Definitely pricey — Reparative Moisture Emulsion”
    • “Just expensive — Hydra-Cool Serum”

Sources: lovi.care, dermstore.com, lovelyskin.com, bluemercury.com, spacenk.com, walmart.com, and more

Questions and answers

Is iS Clinical good for oily skin?

Yes, iS Clinical is a good choice because Lovi rates the brand-focused routine Superior for oily skin, and the Cleansing Complex and Active Serum both rate Superior for this skin type. Reviewers mostly mention that these are lightweight, non-greasy options.

Is iS Clinical worth it?

iS Clinical is a worthwhile choice for shoppers seeking advanced skincare, as Lovi rates its brand-focused routines Superior for dry, oily, sensitive, combination, and acne-prone skin. Reviewers often mention its anti-aging and non-irritating serums, though the brand carries a high price point.

What are iS Clinical's best products?

iS Clinical features standout products like Cleansing Complex and Super Serum Advance+, which Lovi rates Superior for several skin types including dry, oily, and acne-prone skin. Reviewers often mention these anti-aging and texture-improving serums alongside its lightweight moisturizers, though the brand has a high price point.

Dermatologic Therapy, 2022Journal of Cosmetic Dermatology, 2020

Which iS Clinical moisturizer is best for dry skin?

Hydra-Cool Serum is the best iS Clinical moisturizer for dry skin, followed by Reparative Moisture Emulsion. Lovi rates Hydra-Cool Serum High for dry skin, and Reparative Moisture Emulsion High for dry skin.

Does iS Clinical cause breakouts?

iS Clinical is unlikely to cause breakouts, and Lovi rates products like Cleansing Complex and Active Serum High for acne-prone skin. The iS Clinical products on this page are also fragrance-free.

Is iS Clinical fragrance-free?

Yes, every one of the iS Clinical products on this page lists no fragrance in its ingredients. Reviewers often mention that the serums are non-irritating.

What are the key ingredients in iS Clinical products?

The key ingredient in iS Clinical products is hyaluronic acid, which helps improve skin quality and signs of aging.

Dermatologic Therapy, 2022

How do I build a iS Clinical skincare routine?

To build an iS Clinical routine for dry skin in the morning, use a cleanser, a hydrating toner, a moisturizer, and sunscreen, while the evening routine includes a pre-cleanser, cleanser, Super Serum Advance+, and a moisturizer. Once a week, add a nourishing mask into this evening routine.

Dermatologic Therapy, 2022Journal of Cosmetic Dermatology, 2020

Where can I buy iS Clinical, and how much does it cost?

iS Clinical is available to buy on the Lovi page from stores in Italy. Prices on this page range from €175.00 to €175.00, with most falling between those amounts.

What are good alternatives to iS Clinical?

Good alternatives to iS Clinical include CeraVe, Cetaphil, Paula's Choice, Neutrogena, Kiehl's, and Dermalogica. These similar skincare brands have dedicated pages on Lovi to help compare options.

iS Clinical vs CeraVe: which is better?

Lovi rates the iS Clinical-focused routine Superior for dry skin, whereas the CeraVe-focused routine is rated High.

Who owns iS Clinical, and where is it from?

iS Clinical is an American brand founded in 2000, owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Is iS Clinical cruelty-free?

PETA, Leaping Bunny, and Cruelty Free International, the registries Lovi checks, do not list iS Clinical as cruelty-free.

Is iS Clinical good for dry skin?

Yes, iS Clinical is well suited for dry skin, and Lovi rates the iS Clinical-focused routine Superior for this skin type. The brand features lightweight, non-greasy moisturizers and serums that help smooth the skin, while key ingredients like hyaluronic acid help improve skin quality.

Dermatologic Therapy, 2022

Which iS Clinical cleanser is best for oily skin?

Cleansing Complex is the best option because Lovi rates it Superior for oily skin.

Is iS Clinical good for sensitive skin?

Yes, iS Clinical is a good choice because Lovi rates the brand's routine Superior for sensitive skin, and reviewers note that the serums are non-irritating.

Is iS Clinical good for acne-prone skin?

Yes, iS Clinical is good for acne-prone skin because Lovi rates the brand-focused routine Superior for this skin type. Products like Cleansing Complex and Active Serum also fit acne-prone skin well to help keep pores clear and smooth.

Is iS Clinical good for skin with dark spots?

Yes, iS Clinical works well for skin with dark spots, as Lovi rates Cleansing Complex, Active Serum, Super Serum Advance+, and Youth Eye Complex High for this concern. Hyaluronic acid helps improve skin quality.

Dermatologic Therapy, 2022

Is iS Clinical good for mature skin?

Yes, iS Clinical is good for mature skin. Lovi rates Youth Eye Complex Superior and Super Serum Advance+ High for mature skin. Topical hyaluronic acid helps improve skin quality and signs of aging.

Dermatologic Therapy, 2022

Research behind iS Clinical's key ingredients

Behind these ratings

Lovi rates every product from its full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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