🇨🇦Canada

iS Clinical skincare

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

iS Clinical is an American skincare brand founded in 2000 and owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Skincare enthusiasts love iS Clinical for its targeted serums, nourishing moisturizers, gentle cleansers, and specialized eye products, all driven by advanced scientific formulas. Its products suit oily skin and combination skin best, owing to their balanced formulations. For specific concerns, the standout products include the Cleansing Complex for acne-prone skin, the Super Serum Advance+ for skin with dark spots, and the Youth Eye Complex for mature skin. Together, these thoughtful offerings deliver reliable, gentle care for everyday routines.

This page covers some of the most popular iS Clinical products; for the whole iS Clinical range, with a fit score for every product, use the Lovi app.

Other iS Clinical products

People Say

★4.7Overall rating based on 4.4k+ reviews

Reviewers most often praise iS Clinical for gentle hydration, effective acne management, and lightweight textures. The most common complaints are high price points and insufficient hydration for dry skin.

Highlights

  • Lightweight, non-greasy moisturizers Mostly Mentioned
    • “Absorbs beautifully — Reparative Moisture Emulsion”
    • “Drink of water — Hydra-Cool Serum”
  • Texture-improving serums Mostly Mentioned
    • “skin feels softer — Active Serum”
    • “Fades acne scars — Super Serum Advance+”
  • Anti-aging serums Often Mentioned
    • “Reduces fine lines — Super Serum Advance+”
    • “softens fine lines — Active Serum”
  • Non-irritating serums Often Mentioned
    • “Good for sensitive skin — Super Serum Advance+”
    • “It is not oily or pore clogging and hasn't irritated my acne prone skin. — Brightening Complex”
  • High price point Mostly Mentioned
    • “expensive for small bottle — Active Serum”
    • “Definitely pricey — Reparative Moisture Emulsion”
    • “Just expensive — Hydra-Cool Serum”

Sources: lovi.care, dermstore.com, lovelyskin.com, bluemercury.com, spacenk.com, walmart.com, and more

Questions and answers

Is iS Clinical good for oily skin?

Yes, iS Clinical is good for oily skin because the brand-focused routine rates Superior for oily skin. Lovi rates Cleansing Complex and Active Serum Superior for oily skin, helping keep oily skin calm and clear.

Is iS Clinical worth it?

Deciding if iS Clinical is worth it depends on your budget, as reviewers frequently note a high price point alongside its lightweight moisturizers and texture-improving serums. Lovi rates the iS Clinical-focused routine High for dry skin and Superior for oily, sensitive, combination, and acne-prone skin.

What are iS Clinical's best products?

iS Clinical's best products are Cleansing Complex for oily and sensitive skin, Super Serum Advance+ for dry skin, and Youth Eye Complex for mature skin, as these products achieve a Superior fit on Lovi. Reviewers often mention that these lightweight, non-greasy moisturizers and texture-improving serums help smooth the skin.

Dermatologic Therapy, 2022Journal of Cosmetic Dermatology, 2020

Which iS Clinical moisturizer is best for dry skin?

Hydra-Cool Serum is the best moisturizer for dry skin among the iS Clinical products on this page, followed closely by Reparative Moisture Emulsion. Lovi rates both options High for dry skin, and the brand's formulas frequently feature hyaluronic acid, which helps improve skin quality.

Dermatologic Therapy, 2022

Does iS Clinical cause breakouts?

iS Clinical is unlikely to cause breakouts, as the iS Clinical products on this page help keep acne-prone and oily skin clear with lightweight textures and non-irritating formulas. Lovi rates Cleansing Complex and Youth Eye Complex High for acne-prone skin, while Active Serum and Super Serum Advance+ are also well-suited for blemish-prone skin types.

International Journal of Nanomedicine, 2021Journal of Cosmetic Dermatology, 2011

Is iS Clinical fragrance-free?

Yes, every one of the iS Clinical products on this page lists no fragrance in its ingredients. Reviewers also note that the serums are non-irritating.

What are the key ingredients in iS Clinical products?

The key ingredient in iS Clinical products is hyaluronic acid, which helps improve skin quality and signs of aging. Lovi rates the brand-focused routines for dry skin as High, oily skin as Superior, and sensitive skin as Superior.

Dermatologic Therapy, 2022

How do I build a iS Clinical skincare routine?

To build an iS Clinical routine for dry skin, start your morning with Cleansing Complex, follow with Hydra-Cool Serum for moisture, and finish with your own SPF. In the evening, wash with the same cleanser, apply Active Serum as a treatment, and lock it in with Hydra-Cool Serum again.

Where can I buy iS Clinical, and how much does it cost?

iS Clinical products on this page are sold at stores in Canada. Prices range from CA$82.99 to CA$135.00, with most falling between CA$82.99 and CA$135.00.

What are good alternatives to iS Clinical?

Good alternatives to iS Clinical include CeraVe, Cetaphil, Paula's Choice, Neutrogena, Kiehl's, and Dermalogica. Lovi rates these similar brands with pages on its platform.

iS Clinical vs CeraVe: which is better?

Neither brand is universally better, as their fit depends on your skin type. Lovi rates the iS Clinical-focused routine High for dry skin and Superior for oily, sensitive, and combination skin, while CeraVe-focused routines rate Superior across all those skin types.

Who owns iS Clinical, and where is it from?

iS Clinical is an American brand founded in 2000, owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Is iS Clinical cruelty-free?

PETA, Leaping Bunny, and Cruelty Free International, the registries Lovi checks, do not list iS Clinical as cruelty-free.

Is iS Clinical good for dry skin?

iS Clinical is a good choice for dry skin, and Lovi rates the iS Clinical-focused routine High for dry skin. The iS Clinical products on this page include the Cleansing Complex, which rates Average for dry skin, and the Hydra-Cool Serum and Reparative Moisture Emulsion, which both rate High for dry skin.

Which iS Clinical cleanser is best for oily skin?

Cleansing Complex is the best iS Clinical cleanser for oily skin, where Lovi rates it Superior.

Is iS Clinical good for sensitive skin?

Yes, iS Clinical is good for sensitive skin because Lovi rates the iS Clinical-focused routine Superior for sensitive skin. The iS Clinical products on this page list no fragrance in their ingredients.

Is iS Clinical good for acne-prone skin?

Yes, iS Clinical is good for acne-prone skin, as Lovi rates the brand-focused routine High for this skin type. Products like Cleansing Complex and Active Serum offer strong support for oily acne-prone skin. Reviewers often mention that these lightweight serums help improve skin texture without feeling heavy.

International Journal of Nanomedicine, 2021Journal of Cosmetic Dermatology, 2011

Is iS Clinical good for skin with dark spots?

Yes, iS Clinical is good for skin with dark spots because several of its products, such as Cleansing Complex and Super Serum Advance+, rate High for skin with dark spots. Topical antioxidants like vitamin C help improve pigmentation issues and brighten the skin.

Journal of Cosmetic Dermatology, 2020Journal of Cosmetic Dermatology, 2020

Is iS Clinical good for mature skin?

Yes, iS Clinical is good for mature skin, and Lovi rates Youth Eye Complex Superior and Reparative Moisture Emulsion High for mature skin. Topical hyaluronic acid helps improve skin quality and signs of skin aging.

Dermatologic Therapy, 2022

Research behind iS Clinical's key ingredients

Behind these ratings

Lovi rates every product from its full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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