🇳🇱Netherlands

iS Clinical skincare

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

iS Clinical is an American skincare brand founded in 2000 and owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Skincare enthusiasts love iS Clinical for its targeted serums, nourishing moisturizers, purifying cleansers, and restorative eye products, all powered by clinically validated formulas. Its products suit oily acne-prone skin and sensitive skin best due to their gentle yet effective botanical formulations. For specific concerns, the brand offers standout solutions such as the Cleansing Complex for acne-prone skin, the Super Serum Advance+ for skin with dark spots, and the Youth Eye Complex for mature skin. Through these carefully crafted treatments, users can achieve a balanced, radiant complexion with consistent daily care.

This page covers some of the most popular iS Clinical products; for the whole iS Clinical range, with a fit score for every product, use the Lovi app.

Other iS Clinical products

People Say

★4.7Overall rating based on 4.4k+ reviews

Reviewers most often praise iS Clinical for gentle hydration, effective acne management, and lightweight textures. The most common complaints are high price points and insufficient hydration for dry skin.

Highlights

  • Lightweight, non-greasy moisturizers Mostly Mentioned
    • “Absorbs beautifully — Reparative Moisture Emulsion”
    • “Drink of water — Hydra-Cool Serum”
  • Texture-improving serums Mostly Mentioned
    • “skin feels softer — Active Serum”
    • “Fades acne scars — Super Serum Advance+”
  • Anti-aging serums Often Mentioned
    • “Reduces fine lines — Super Serum Advance+”
    • “softens fine lines — Active Serum”
  • Non-irritating serums Often Mentioned
    • “Good for sensitive skin — Super Serum Advance+”
    • “It is not oily or pore clogging and hasn't irritated my acne prone skin. — Brightening Complex”
  • High price point Mostly Mentioned
    • “expensive for small bottle — Active Serum”
    • “Definitely pricey — Reparative Moisture Emulsion”
    • “Just expensive — Hydra-Cool Serum”

Sources: lovi.care, dermstore.com, lovelyskin.com, bluemercury.com, spacenk.com, walmart.com, and more

Questions and answers

Is iS Clinical good for oily skin?

Yes, iS Clinical is good for oily skin. Lovi rates Cleansing Complex and Active Serum Superior for oily skin.

Is iS Clinical worth it?

iS Clinical is a worthwhile choice because reviewers frequently praise its anti-aging serums and texture-improving serums, though the brand carries a high price point. Lovi rates the iS Clinical-focused routine Superior for dry skin, sensitive skin, and oily skin.

What are iS Clinical's best products?

iS Clinical features Youth Eye Complex as its top choice for mature skin and Cleansing Complex for oily skin. Lovi rates the brand-focused routine Superior for sensitive, acne-prone, and oily skin.

Which iS Clinical moisturizer is best for dry skin?

The best moisturizer by iS Clinical for dry skin is Hydra-Cool Serum, which Lovi rates High, followed by Reparative Moisture Emulsion with a High fit level as well.

Does iS Clinical cause breakouts?

iS Clinical is unlikely to cause breakouts, as the brand features lightweight, non-greasy moisturizers and serums that fit acne-prone skin well.

Is iS Clinical fragrance-free?

Yes, the iS Clinical products on this page list no fragrance in their ingredients. Reviewers often mention that the brand's formulas are lightweight and non-irritating.

What are the key ingredients in iS Clinical products?

Hyaluronic acid is a key ingredient featured across the iS Clinical products on this page, helping to improve skin quality and signs of aging.

Dermatologic Therapy, 2022

How do I build a iS Clinical skincare routine?

To build an iS Clinical routine for dry skin in the morning, use Cleansing Complex, Supple Preparation Unscented Toner, Hydra-Cool Serum, and Daily Soft Touch Sunscreen. In the evening, use Ultra Hyalon Cleansing Cream, Cleansing Complex, 1025 Dokdo Cleansing Water, Super Serum Advance+, and Hydra-Cool Serum. Once a week, add Water Sleeping Mask_EX to the evening steps.

Where can I buy iS Clinical, and how much does it cost?

iS Clinical is available on this page at stores in the Netherlands, with prices ranging from €60.72 to €219.54 and most falling between €165.00 and €211.62.

What are good alternatives to iS Clinical?

Good alternatives to iS Clinical include CeraVe, Cetaphil, Paula's Choice, Neutrogena, Kiehl's, and Dermalogica, which all have brand pages on Lovi.

iS Clinical vs CeraVe: which is better?

iS Clinical is better for sensitive skin, where Lovi rates the brand-focused routine Superior compared to CeraVe, while both brands are equally matched for oily and acne-prone skin. For dry skin, CeraVe rates High, whereas the iS Clinical-focused routine rates Superior.

Who owns iS Clinical, and where is it from?

iS Clinical is an American brand founded in 2000, owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Is iS Clinical cruelty-free?

PETA, Leaping Bunny, and Cruelty Free International, the registries Lovi checks, do not list iS Clinical as cruelty-free.

Is iS Clinical good for dry skin?

Lovi rates the iS Clinical-focused routine Superior for dry skin. The brand offers options like Super Serum Advance+ and Cleansing Complex that help improve dry skin, and the iS Clinical products on this page list no fragrance.

Dermatologic Therapy, 2022

Which iS Clinical cleanser is best for oily skin?

Cleansing Complex is the best choice for oily skin. Lovi rates Cleansing Complex Superior for oily skin.

Is iS Clinical good for sensitive skin?

Yes, iS Clinical is good for sensitive skin and features in brand routines that Lovi rates Superior for sensitive skin. The iS Clinical products on this page list no fragrance in their ingredients, and reviewers often mention their non-irritating serums.

Is iS Clinical good for acne-prone skin?

Yes, iS Clinical fits acne-prone skin well, with Lovi rating its Cleansing Complex, Active Serum, Super Serum Advance+, and Youth Eye Complex High to Superior for this skin type. Reviewers often mention its texture-improving serums, and the brand's focused routines rate Superior for acne-prone skin.

Is iS Clinical good for skin with dark spots?

Yes, iS Clinical fits skin with dark spots well, as Lovi rates Cleansing Complex, Active Serum, Hydra-Cool Serum, Super Serum Advance+, and Youth Eye Complex High for this concern. Reviewers often mention that its serums help smooth skin texture and improve signs of aging.

Journal of Cosmetic Dermatology, 2020Journal of Cosmetic Dermatology, 2020

Is iS Clinical good for mature skin?

Yes, iS Clinical is good for mature skin, with Lovi rating Youth Eye Complex Superior and Reparative Moisture Emulsion and Super Serum Advance+ High for this skin type. Reviewers often mention its anti-aging serums, which help improve skin quality and signs of aging.

Dermatologic Therapy, 2022Journal of Cosmetic Dermatology, 2020

Research behind iS Clinical's key ingredients

Behind these ratings

Lovi rates every product from its full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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