🇺🇸United States

iS Clinical skincare

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

iS Clinical is an American skincare brand founded in 2000 and owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Skincare enthusiasts love iS Clinical for its targeted serums, nourishing moisturizers, gentle cleansers, and restorative eye products, all powered by meticulously crafted formulas. Its products suit oily skin and oily acne-prone skin best, helping to balance and refine the complexion. For specific concerns, the Cleansing Complex addresses acne-prone skin, the Super Serum Advance+ targets dark spots, and the Youth Eye Complex cares for mature skin. Through these refined offerings, the brand delivers thoughtful results with reliable precision.

This page covers some of the most popular iS Clinical products; for the whole iS Clinical range, with a fit score for every product, use the Lovi app.

Other iS Clinical products

People Say

★4.7Overall rating based on 4.4k+ reviews

Reviewers most often praise iS Clinical for gentle hydration, effective acne management, and lightweight textures. The most common complaints are high price points and insufficient hydration for dry skin.

Highlights

  • Lightweight, non-greasy moisturizers Mostly Mentioned
    • “Absorbs beautifully — Reparative Moisture Emulsion”
    • “Drink of water — Hydra-Cool Serum”
  • Texture-improving serums Mostly Mentioned
    • “skin feels softer — Active Serum”
    • “Fades acne scars — Super Serum Advance+”
  • Anti-aging serums Often Mentioned
    • “Reduces fine lines — Super Serum Advance+”
    • “softens fine lines — Active Serum”
  • Non-irritating serums Often Mentioned
    • “Good for sensitive skin — Super Serum Advance+”
    • “It is not oily or pore clogging and hasn't irritated my acne prone skin. — Brightening Complex”
  • High price point Mostly Mentioned
    • “expensive for small bottle — Active Serum”
    • “Definitely pricey — Reparative Moisture Emulsion”
    • “Just expensive — Hydra-Cool Serum”

Sources: lovi.care, dermstore.com, lovelyskin.com, bluemercury.com, spacenk.com, walmart.com, and more

Questions and answers

Is iS Clinical good for oily skin?

Yes, iS Clinical fits oily skin very well, as Lovi rates the brand-focused routine for oily skin as Superior. Reviewers often mention the lightweight, non-greasy feel of the moisturizers and the texture-improving serums.

Is iS Clinical worth it?

Reviews often mention that iS Clinical products carry a high price point while also praising their lightweight, non-greasy moisturizers and texture-improving serums. Lovi rates the brand-focused routines as Superior for dry, oily, sensitive, combination, and acne-prone skin.

What are iS Clinical's best products?

The best iS Clinical products depend on the skin type, with Cleansing Complex rating Superior for oily, combination, and sensitive skin, and Youth Eye Complex rating Superior for mature skin. Super Serum Advance+ rates Superior for dry skin, while Hydra-Cool Serum rates High for dry and sensitive skin.

Which iS Clinical moisturizer is best for dry skin?

Hydra-Cool Serum is the best iS Clinical moisturizer for dry skin, and Reparative Moisture Emulsion is also a strong option.

Does iS Clinical cause breakouts?

iS Clinical is unlikely to cause breakouts, as the iS Clinical products on this page help keep pores clear and are reported by reviewers to be lightweight and non-greasy.

Is iS Clinical fragrance-free?

Yes, the iS Clinical products on this page list no fragrance in their ingredients. Reviewers often mention these products as non-irritating.

What are the key ingredients in iS Clinical products?

Hyaluronic acid is a key ingredient across the iS Clinical products on this page. Lovi rates hyaluronic acid as beneficial for improving skin quality and signs of skin aging.

Dermatologic Therapy, 2022

How do I build a iS Clinical skincare routine?

To build an iS Clinical routine for dry skin, start your morning with Cleansing Complex, Calming Deep Moisture Toner, Hydra-Cool Serum, and Piedmont Waterfull Mild Sunscreen. In the evening, use Ultra Hyalon Cleansing Cream, Cleansing Complex, Super Serum Advance+, and Hydra-Cool Serum. Once a week, add Vita Essential Mask to your evening steps for extra nourishment.

Dermatologic Therapy, 2022Journal of Cosmetic Dermatology, 2020

Where can I buy iS Clinical, and how much does it cost?

Shoppers can buy iS Clinical on Amazon US, where prices range from $49.00 to $177.00, with most products falling between $108.00 and $155.00.

What are good alternatives to iS Clinical?

Good alternatives to iS Clinical include brands with pages on Lovi like CeraVe, Cetaphil, Paula's Choice, Neutrogena, Kiehl's, and Dermalogica. These alternative brands offer similar skincare routines and options for various skin types.

iS Clinical vs CeraVe: which is better?

iS Clinical and CeraVe both rate Superior for dry skin, oily skin, sensitive skin, combination skin, and acne-prone skin, so neither brand is better across those types. Reviewers mention that iS Clinical offers texture-improving and anti-aging serums alongside lightweight moisturizers, though at a high price point.

Who owns iS Clinical, and where is it from?

iS Clinical is an American brand founded in 2000, owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Is iS Clinical cruelty-free?

PETA, Leaping Bunny, and Cruelty Free International, the registries Lovi checks, do not list iS Clinical as cruelty-free.

Is iS Clinical good for dry skin?

iS Clinical is a good choice for dry skin, as Lovi rates the brand-focused routine Superior for this skin type. Reviewers mostly mention that the moisturizers are lightweight and non-greasy, and the iS Clinical products on this page list no fragrance.

Which iS Clinical cleanser is best for oily skin?

Cleansing Complex is the best for oily skin, where Lovi rates it Superior.

Is iS Clinical good for sensitive skin?

iS Clinical is well suited for sensitive skin, as Lovi rates the brand-focused routine Superior for this skin type. Reviewers frequently mention that the serums are non-irritating.

Is iS Clinical good for acne-prone skin?

Yes, iS Clinical fits acne-prone skin well, as Lovi rates the brand-focused routine Superior for this skin type. The iS Clinical products on this page help improve texture and keep skin calm without feeling heavy.

Is iS Clinical good for skin with dark spots?

iS Clinical is a good choice for skin with dark spots because several of its targeted serums and creams help brighten the complexion and smooth out uneven tones. Lovi rates Cleansing Complex, Active Serum, Hydra-Cool Serum, Super Serum Advance+, and Youth Eye Complex High for skin with dark spots.

Journal of Cosmetic Dermatology, 2020Journal of Cosmetic Dermatology, 2020

Is iS Clinical good for mature skin?

iS Clinical is well-suited for mature skin, offering products like Super Serum Advance+ and Youth Eye Complex that help address signs of aging. Lovi rates Youth Eye Complex as Superior for mature skin.

Journal of Cosmetic Dermatology, 2020Dermatologic Therapy, 2022

Research behind iS Clinical's key ingredients

Behind these ratings

Lovi rates every product from its full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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