🇩🇪Germany

iS Clinical skincare

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

iS Clinical is an American skincare brand founded in 2000 and owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Skincare enthusiasts love iS Clinical for its targeted serums, nourishing moisturizers, gentle cleansers, and specialized eye products, all powered by carefully selected formulas. Its products suit sensitive skin and oily acne-prone skin best, addressing these complex conditions with thoughtful precision. When targeting specific concerns, the Cleansing Complex offers relief for acne-prone skin, the Super Serum Advance+ addresses dark spots, and the Youth Eye Complex revitalizes mature skin. Across every formulation, the brand delivers reliable results that support long-term skin health.

This page covers some of the most popular iS Clinical products; for the whole iS Clinical range, with a fit score for every product, use the Lovi app.

Other iS Clinical products

People Say

★4.7Overall rating based on 4.4k+ reviews

Reviewers most often praise iS Clinical for gentle hydration, effective acne management, and lightweight textures. The most common complaints are high price points and insufficient hydration for dry skin.

Highlights

  • Lightweight, non-greasy moisturizers Mostly Mentioned
    • “Absorbs beautifully — Reparative Moisture Emulsion”
    • “Drink of water — Hydra-Cool Serum”
  • Texture-improving serums Mostly Mentioned
    • “skin feels softer — Active Serum”
    • “Fades acne scars — Super Serum Advance+”
  • Anti-aging serums Often Mentioned
    • “Reduces fine lines — Super Serum Advance+”
    • “softens fine lines — Active Serum”
  • Non-irritating serums Often Mentioned
    • “Good for sensitive skin — Super Serum Advance+”
    • “It is not oily or pore clogging and hasn't irritated my acne prone skin. — Brightening Complex”
  • High price point Mostly Mentioned
    • “expensive for small bottle — Active Serum”
    • “Definitely pricey — Reparative Moisture Emulsion”
    • “Just expensive — Hydra-Cool Serum”

Sources: lovi.care, dermstore.com, lovelyskin.com, bluemercury.com, spacenk.com, walmart.com, and more

Questions and answers

Is iS Clinical good for oily skin?

Yes, iS Clinical fits oily skin very well, as Lovi rates the iS Clinical-focused routine Superior for oily skin. The brand offers several top-rated products for this skin type, including Cleansing Complex, Active Serum, and Super Serum Advance+.

Is iS Clinical worth it?

iS Clinical products are generally pricey, with prices on this page mostly ranging between €113.00 and €134.00. Reviewers often mention a high price point, but they also frequently highlight lightweight, non-greasy moisturizers and texture-improving serums.

What are iS Clinical's best products?

iS Clinical's best products vary by skin type, with Cleansing Complex and Youth Eye Complex leading as Superior for several skin needs, while Super Serum Advance+ is Superior specifically for dry skin. Reviewers most often mention that the serums improve texture and fight aging, while the moisturizers feel lightweight and non-greasy.

Dermatologic Therapy, 2022Journal of Cosmetic Dermatology, 2020

Which iS Clinical moisturizer is best for dry skin?

Hydra-Cool Serum is the best choice among the iS Clinical moisturizers on this page for dry skin, where Lovi rates it High, followed by Reparative Moisture Emulsion, which also rates High.

Does iS Clinical cause breakouts?

iS Clinical products are unlikely to cause breakouts, as the brand features lightweight, non-greasy moisturizers and texture-improving serums that fit oily acne-prone skin well. Lovi rates the iS Clinical routine Superior for acne-prone skin.

Is iS Clinical fragrance-free?

Yes, every one of the iS Clinical products on this page lists no fragrance in its ingredients.

What are the key ingredients in iS Clinical products?

Hyaluronic acid is a key ingredient featured across the iS Clinical products on this page. Topical use of hyaluronic acid helps improve skin quality and signs of skin aging.

Dermatologic Therapy, 2022

How do I build a iS Clinical skincare routine?

To build a routine with iS Clinical for dry skin, start your morning by washing with Cleansing Complex, follow with Hydra-Cool Serum for moisture, and finish with a daily SPF. In the evening, cleanse again with Cleansing Complex, apply Super Serum Advance+ as your treatment, and lock it in with Hydra-Cool Serum. Once a week, add Vita Essential Mask to your evening steps for extra nourishment.

Dermatologic Therapy, 2022Journal of Cosmetic Dermatology, 2020

Where can I buy iS Clinical, and how much does it cost?

iS Clinical products are available at stores in Germany, with prices on this page ranging from €58.00 to €155.00 and most falling between €113.00 and €134.00.

What are good alternatives to iS Clinical?

The brands CeraVe, Cetaphil, Paula's Choice, Neutrogena, Kiehl's, and Dermalogica are similar brands with pages on Lovi.

iS Clinical vs CeraVe: which is better?

Lovi rates the iS Clinical-focused routine Superior for dry skin, oily skin, sensitive skin, combination skin, and acne-prone skin, which is the same or higher than CeraVe across these skin types. Reviewers note that iS Clinical offers texture-improving and anti-irritating serums alongside lightweight, non-greasy moisturizers, though the brand carries a high price point.

Who owns iS Clinical, and where is it from?

iS Clinical is an American brand founded in 2000, owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Is iS Clinical cruelty-free?

PETA, Leaping Bunny, and Cruelty Free International, the registries Lovi checks, do not list iS Clinical as cruelty-free.

Is iS Clinical good for dry skin?

Lovi rates the iS Clinical-focused routine Superior for dry skin. For individual products on this page, Hydra-Cool Serum and Super Serum Advance+ fit dry skin best, while Cleansing Complex and Reparative Moisture Emulsion reach High or Average levels. Hyaluronic acid in the formulas helps maintain moisture and improve skin quality.

Dermatologic Therapy, 2022

Which iS Clinical cleanser is best for oily skin?

Cleansing Complex is the best choice, as Lovi rates Cleansing Complex Superior for oily skin.

Is iS Clinical good for sensitive skin?

Yes, iS Clinical fits sensitive skin very well. Lovi rates the iS Clinical-focused routine Superior for sensitive skin, and the iS Clinical products on this page list no fragrance in their ingredients.

Is iS Clinical good for acne-prone skin?

Yes, iS Clinical is well-suited for acne-prone skin, as Lovi rates the brand-focused routine Superior for this skin type. Reviewers often mention its texture-improving and non-irritating serums, which help smooth the skin.

Journal of Cosmetic Dermatology, 2011International Journal of Nanomedicine, 2021

Is iS Clinical good for skin with dark spots?

iS Clinical is a good choice for skin with dark spots, featuring texture-improving serums and anti-aging serums like Super Serum Advance+ and Brightening Complex that help target uneven tone. Lovi rates Cleansing Complex, Active Serum, Hydra-Cool Serum, Youth Eye Complex, and Super Serum Advance+ High for skin with dark spots, while Reparative Moisture Emulsion and Brightening Complex receive Average ratings.

Journal of Cosmetic Dermatology, 2020Journal of Cosmetic Dermatology, 2020

Is iS Clinical good for mature skin?

Yes, iS Clinical is a good choice for mature skin, as Lovi rates the brand-focused routine High for this skin type. Reviewers often mention its anti-aging serums, and key ingredients like hyaluronic acid help improve skin quality and signs of aging.

Dermatologic Therapy, 2022

Research behind iS Clinical's key ingredients

Behind these ratings

Lovi rates every product from its full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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