🇦🇺Australia

iS Clinical skincare

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

iS Clinical is an American skincare brand founded in 2000 and owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

iS Clinical is beloved for its sophisticated serums, moisturizers, cleansers, and eye products, all driven by meticulously crafted formulas. Its products suit oily acne-prone skin and oily skin best because of their targeted botanical designs. The standout products for specific concerns include the Cleansing Complex for acne-prone skin, the Super Serum Advance+ for skin with dark spots, and the Youth Eye Complex for mature skin. Through these carefully balanced formulations, the brand delivers reliable botanical support that elevates daily routines.

This page covers some of the most popular iS Clinical products; for the whole iS Clinical range, with a fit score for every product, use the Lovi app.

Other iS Clinical products

People Say

★4.7Overall rating based on 4.4k+ reviews

Reviewers most often praise iS Clinical for gentle hydration, effective acne management, and lightweight textures. The most common complaints are high price points and insufficient hydration for dry skin.

Highlights

  • Lightweight, non-greasy moisturizers Mostly Mentioned
    • “Absorbs beautifully — Reparative Moisture Emulsion”
    • “Drink of water — Hydra-Cool Serum”
  • Texture-improving serums Mostly Mentioned
    • “skin feels softer — Active Serum”
    • “Fades acne scars — Super Serum Advance+”
  • Anti-aging serums Often Mentioned
    • “Reduces fine lines — Super Serum Advance+”
    • “softens fine lines — Active Serum”
  • Non-irritating serums Often Mentioned
    • “Good for sensitive skin — Super Serum Advance+”
    • “It is not oily or pore clogging and hasn't irritated my acne prone skin. — Brightening Complex”
  • High price point Mostly Mentioned
    • “expensive for small bottle — Active Serum”
    • “Definitely pricey — Reparative Moisture Emulsion”
    • “Just expensive — Hydra-Cool Serum”

Sources: lovi.care, dermstore.com, lovelyskin.com, bluemercury.com, spacenk.com, walmart.com, and more

Questions and answers

Is iS Clinical good for oily skin?

Yes, iS Clinical is a good choice because Lovi rates the brand-focused routine Superior for oily skin. The iS Clinical products on this page help keep skin clear and balanced without feeling heavy.

Is iS Clinical worth it?

Deciding if iS Clinical is worth it depends on personal budget, as reviewers mostly mention a high price point. However, Lovi rates its brand-focused routines Superior for dry, oily, sensitive, combination, and acne-prone skin, and reviewers frequently highlight its lightweight, non-greasy moisturizers and texture-improving serums.

What are iS Clinical's best products?

iS Clinical's best products are Cleansing Complex for oily and sensitive skin, Super Serum Advance+ for dry skin, and Youth Eye Complex for mature skin, as Lovi rates these combinations as Superior. Reviewers note that these are lightweight, non-greasy moisturizers and texture-improving, non-irritating serums.

Which iS Clinical moisturizer is best for dry skin?

Hydra-Cool Serum is the best iS Clinical moisturizer for dry skin, followed by Reparative Moisture Emulsion. Lovi rates both High for dry skin.

Does iS Clinical cause breakouts?

iS Clinical is unlikely to cause breakouts, as the iS Clinical products on this page help keep skin clear and smooth. Lovi rates Active Serum and Reparative Moisture Emulsion High for acne-prone skin, and Cleansing Complex High as well.

Is iS Clinical fragrance-free?

Yes, the iS Clinical products on this page list no fragrance in their ingredients. This helps keep the formulas gentle for sensitive skin.

What are the key ingredients in iS Clinical products?

Hyaluronic acid is a key ingredient featured across the iS Clinical products on this page. Topical hyaluronic acid helps improve skin quality and signs of skin aging.

Dermatologic Therapy, 2022

How do I build a iS Clinical skincare routine?

To build an iS Clinical routine for dry skin in the morning, apply Cleansing Complex, Calming Deep Moisture Toner, Hydra-Cool Serum, and Photoderm Mineral Fluide SPF50+. In the evening, use Ultra Hyalon Cleansing Cream, Cleansing Complex, Super Serum Advance+, and Hydra-Cool Serum. Lovi rates the iS Clinical-focused routine for dry skin as Superior.

Where can I buy iS Clinical, and how much does it cost?

iS Clinical products are available on Lovi through Australian stores listed on this page. Prices range from A$77.97 to A$265.76, with most items falling between A$128.18 and A$178.51.

What are good alternatives to iS Clinical?

CeraVe, Cetaphil, Paula's Choice, Neutrogena, Kiehl's, and Dermalogica are good alternatives to iS Clinical because they are similar brands with pages on Lovi. Lovi rates CeraVe as a High fit for dry skin, oily skin, sensitive skin, combination skin, and acne-prone skin.

iS Clinical vs CeraVe: which is better?

iS Clinical is a better choice than CeraVe because Lovi rates the iS Clinical-focused routine as Superior for dry, oily, sensitive, combination, and acne-prone skin, compared to High for CeraVe. Reviewers frequently mention that iS Clinical offers texture-improving and anti-aging serums, though they also note a high price point.

Who owns iS Clinical, and where is it from?

iS Clinical is an American brand founded in 2000, owned by Science of Skincare, LLC.

isclinicalskincare.co.zaisclinical.comisclinical.ietracxn.com

Is iS Clinical cruelty-free?

PETA, Leaping Bunny, and Cruelty Free International, the registries Lovi checks, do not list iS Clinical as cruelty-free.

Is iS Clinical good for dry skin?

Lovi rates iS Clinical-focused routines Superior for dry skin. The brand offers products like Super Serum Advance+ and Hydra-Cool Serum to help smooth and moisturize dry skin, and the iS Clinical products on this page are fragrance-free.

Dermatologic Therapy, 2022Journal of Cosmetic Dermatology, 2020

Which iS Clinical cleanser is best for oily skin?

Cleansing Complex is the best option for oily skin, as Lovi rates it Superior for that skin type.

Is iS Clinical good for sensitive skin?

Yes, iS Clinical fits sensitive skin very well, as Lovi rates the brand-focused routine Superior for sensitive skin. Reviewers often mention that the serums are non-irritating.

Is iS Clinical good for acne-prone skin?

Yes, iS Clinical is well-suited for acne-prone skin, as Lovi rates the brand-focused routine Superior for this skin type. Reviewers often mention its texture-improving serums, and the iS Clinical products on this page list no fragrance.

Is iS Clinical good for skin with dark spots?

Yes, iS Clinical is good for skin with dark spots because several of its products help brighten the skin. Lovi rates Active Serum and Super Serum Advance+ High for skin with dark spots. The iS Clinical products on this page help improve skin texture and tone.

Journal of Cosmetic Dermatology, 2020Journal of Cosmetic Dermatology, 2020

Is iS Clinical good for mature skin?

Yes, iS Clinical is good for mature skin because Lovi rates Youth Eye Complex and Reparative Moisture Emulsion High for mature skin, and Super Serum Advance+ is also rated High. The iS Clinical products on this page help smooth and soften mature skin while reducing visible signs of aging.

Dermatologic Therapy, 2022Journal of Cosmetic Dermatology, 2020

Research behind iS Clinical's key ingredients

Behind these ratings

Lovi rates every product from its full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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