Shiseido Benefiance Wrinkle Smoothing Cream Enriched for sensitive skin

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Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Co-encapsulation of alpha-tocopherol and alpha-tocopheryl acetate in nanostructured lipid carrier gel formulations significantly enhanced moisture retention up to 68% and improved skin elasticity in human volunteers compared to a solution gel.

  Scientific Reports, 2025

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated.

  Antioxidants, 2021

• Treatment with a cream containing 10% Laminaria japonica extract increased skin hydration by 14.44% and reduced transepidermal water loss to about 20% of control levels over an 8-hour period on human forearms.

  Journal of Cosmetic Science, 2013

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups.

  Military Medicine, 2024

• Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms.

  Clinical and Experimental Dermatology, 2007

Ingredients

Water, Cetyl Ethylhexanoate, Glycerin, Niacinamide, Nylon-12, Cetearyl Alcohol, Dipropylene Glycol, Sd Alcohol 40-B Alcohol Denat, Caprylic Capric Triglyceride, Phytosteryl Macadamiate, Glyceryl Stearate, Dimethicone, Diisostearyl Malate, Beheneth-20, Phenoxyethanol, Tocopheryl Acetate, Erythritol, Peg Ppg-14 7 Dimethyl Ether, Peg Ppg-17 4 Dimethyl Ether, Hdi Trimethylol Hexyllactone Crosspolymer, Carbomer, Parfum, Butylene Glycol, Sodium Citrate, Trisodium Edta, Potassium Hydroxide, Citric Acid, Caffeine, Xanthan Gum, Sodium Metabisulfite, Sodium Metaphosphate, Iron Oxides Ci 77492, Ppg-3 Dipivalate, Linalool, Tocopherol, Sapindus Mukorossi Peel Extract, Limonene, Citronellol, Silica, Geraniol, Angelica Keiskei Stem Extract Leaf, Alpha-Isomethyl Ionone, Camellia Sinensis Leaf Extract, Citrus Junos Seed Extract, Ziziphus Jujuba Fruit Extract, Iron Oxides Ci 77491, Eucheuma Serra Grateloupia Sparsa Saccharina Angustata Ulva Linza Undaria Pinnatifida Extract, Curcuma Longa Extract Rhizome, Saccharina Angustata Undaria Pinnatifida Extract, Chlorella Vulgaris Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.