Sesderma Azelac RU Liposomal Serum for oily skin
Azelaic Acid
Tranexamic Acid
Retinol
Niacin
4-ButylresorcinolHigh
- HighOily Skin Fit
- AverageEffectiveness
- HighSafety
A great choice for oily skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for oily skin, this serum utilizes BHA and Retinol to regulate cell turnover and exfoliate, addressing concerns like oily shine by promoting smoother skin texture.
- Azelaic acid and tranexamic acid offer moderate brightening and evening of skin tone, complementing the primary function for oily skin.
- The formulation is safe for your oily skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
People Say
★4.2Overall rating based on 100+ reviewsBased on limited data, users frequently report this serum effectively brightens the complexion and reduces hyperpigmentation like melasma, sun spots, and acne marks, leading to smoother and more luminous skin. Many appreciate its fast absorption and lightweight feel. Some users with sensitive or dry skin find it can be drying and recommend using a moisturizer.
Highlights
Fast absorption Mostly Mentioned
- “absorbing very fast”
- “lightweight”
- “no oily residue”
- “sinks deep into skin”
Fades dark spots Often Mentioned
- “huge difference in pigmentation”
- “removed stains from face”
- “fades spots fast”
- “marks down to faint shadows”
Improves texture Often Mentioned
- “skin smooth and luminous”
- “leaves skin glowy”
- “soft and alive”
- “texture is better”
Acne control Sometimes Noted
- “kept breakouts at bay”
- “pimples heal faster”
- “good for acne”
- “prevented new imperfections”
Drying effect Sometimes Noted
- “cheeks felt tight”
- “can dry you out”
- “needs moisturizer”
- “slightly aggressive initially”
High price Rarely Noted
- “expensive”
- “small bottle”
- “pricey for the size”
Slow results Rarely Noted
- “didn't see any effect”
- “oldest marks still there”
- “not a magic wand”
- “took forever to work”
Sticky finish Rarely Noted
- “sticky at first”
- “slight tacky feel”
- “feels a bit sticky”
Sources: lovi.care, notino.ie, influenster.com, skinsort.com, perfumesclub.co.uk, makeup.uk, and more
Questions and answers
What makes Sesderma Azelac RU Liposomal Serum a great fit for oily skin?
This serum is a great fit because it uses BHA and retinol to gently exfoliate and keep oily shine under control for smoother skin. It also includes azelaic acid and tranexamic acid to help brighten and even out your skin tone safely without irritation.
Which ingredients make this serum a good fit for oily skin?
BHA and retinol make this serum a great fit for oily skin by helping to regulate cell turnover and exfoliate, which reduces oily shine and keeps skin smooth. Azelaic acid and tranexamic acid also help brighten and even out skin tone safely.
What does Azelaic Acid do for oily skin?
Azelaic acid helps calm acne and clear out pores without changing how much oil your skin makes. It targets multiple causes of breakouts and helps fade dark spots left behind by pimples.
Dermatologic Therapy, 2022Acta Dermato-venereologica. Supplementum, 1989
What does Tranexamic Acid do for oily skin?
Tranexamic acid helps oily skin by calming redness and keeping the skin barrier strong, which is especially useful when dealing with stubborn dark spots and uneven tone. This ingredient is unlikely to clog pores and may improve overall skin texture while balancing the complexion.
International Journal of Dermatology, 2014Clinical, Cosmetic and Investigational Dermatology, 2024
Where does this serum go in a skincare routine for oily skin?
This serum goes in your evening routine, applied after cleansing and before your moisturizer. Putting it at night keeps things simple and helps protect your skin around sun exposure.
Can I use this serum with vitamin C, and in what order?
You can use this serum with vitamin C by applying vitamin C in your morning routine and this treatment at night, as this helps avoid combining too many active ingredients at once.
How often should I use this serum?
This serum is used in your evening routine, starting at once a week and slowly increasing the frequency if your skin tolerates it well. Retinol and azelaic acid help smooth texture and brighten tone safely over time.
Can this serum clog pores, cause breakouts or purging for oily skin?
This serum is unlikely to clog pores or cause breakouts on oily skin, as it uses ingredients like BHA and retinol to gently clear dead skin and keep pores clean. It has a great safety profile for this skin type, with no harsh ingredients that typically trigger irritation.
Is this serum fragrance-free and alcohol-free?
It contains fragrance (parfum) and drying alcohol (alcohol and alcohol denat).
What the research says
Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.
International Journal of Cosmetic Science, 2017Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo.
Dermatology and Therapy, 2024Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne.
Pharmaceutics, 2021Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks.
Journal of the European Academy of Dermatology and Venereology, 2023Topical administration of 20% azelaic acid cream and 5% tranexamic acid solution comparably improved acne-related postinflammatory hyperpigmentation in patients with acne vulgaris, while tranexamic acid demonstrated a significantly better safety profile at week 4.
Journal of Research in Medical Sciences, 2023Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.
Journal of Controlled Release, 2018Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle.
Archives of Dermatological Research, 2017Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks.
Journal of Cosmetic Dermatology, 20164-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks.
Journal of the European Academy of Dermatology and Venereology, 2013Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications.
Molecular Pharmaceutics, 2017
Ingredients
Water, Lecithin, Propanediol, Alcohol, Bellis Perennis Flower Extract, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, Propylene Glycol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-Butylresorcinol, Alcohol Denat, Ascorbyl Glucoside, Azelaic Acid, Bha, Bht, Caprylic Capric Triglyceride, Carbomer, Citronellyl Methylcrotonate, Grapefruit Fruit Extract, Diacetyl Boldine, Dipotassium Phosphate, Disodium Edta, Disodium Phosphate, Ethylhexylglycerin, Glycerin, Glycyrrhetinic Acid, Hydrochloric Acid, Hydroxypropyl Cyclodextrin, Melissa Officinalis Leaf Extract, Morus Alba Root Extract, Niacin, Nicotiana Benthamiana Sh-Polypeptide-7, Parfum, Peg Ppg-20 6 Dimethicone, Phenethyl Alcohol, Phenoxyethanol, Polysorbate 20, Potassium Phosphate, Potassium Sorbate, Retinal, Retinol, Sodium Chloride, Sodium Cholate, Sodium Hydroxide, Tocopheryl Acetate, Tranexamic Acid, Triethanolamine, Triisopropanolamine, Undecylenoyl Phenylalanine, Xanthan Gum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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