Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity
Ethanol · Journal of Occupational Medicine and Toxicology, 2008Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid)
Tretinoin · The New England Journal of Medicine, 1993Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress
Epigallocatechin gallate, Camellia sinensis, Camellia sinensis extract · Carcinogenesis, 2001Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation
Niacinamide · Antioxidants, 2021Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate
Benzyl alcohol · International Journal of Toxicology, 2001Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments
Rice bran oil · Journal of Nanobiotechnology, 2011Cosmetic benefits of astaxanthin on humans subjects
Astaxanthin powder, Astaxanthin · Acta Biochimica Polonica, 2012Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
Sodium hyaluronate molecule, Hyaluronic acid, Sodium hyaluronate · Dermatologic Therapy, 2022Topical use of dexpanthenol in skin disorders
Panthenol, Panthenol vitamin b5, D-pantothenyl alcohol, Vitamin b5 panthenol, Vitamin b5, Panthenol b5 · American Journal of Clinical Dermatology, 2002The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review
Aloe barbadensis, Aloe barbadensis leaf extract, Aloe barbadensis leaf juice, Aloe barbadensis leaf, Aloe barbadensis extract · Iranian Journal of Medical Sciences, 2019Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring
Curcuma kwangsiensis extract · Biomaterials, 2015Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study
C.e.l.l · Journal of Cosmetic Dermatology, 2023Bifidobacterium longum lysate, a new ingredient for reactive skin
1 · Experimental Dermatology, 2010Cutaneous photoprotection from ultraviolet injury by green tea polyphenols
Camellia sinensis extract · Journal of the American Academy of Dermatology, 2001Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes
Epigallocatechin gallate, Camellia sinensis · The Journal of Investigative Dermatology, 2013Improvement of naturally aged skin with vitamin A (retinol)
Retinol, Retinol vitamin a · Archives of Dermatology, 2007Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin
Arabidopsis thaliana extract · Proceedings of the National Academy of Sciences of the United States of America, 2000Topical Retinoids in Acne Vulgaris: A Systematic Review
Retinol alternative · American Journal of Clinical Dermatology, 2019Regulatory effects of Lactobacillus plantarum-GMNL6 on human skin health by improving skin microbiome
Lactobacillus, Live probiotic · International Journal of Medical Sciences, 2021Quercitrin protects skin from UVB-induced oxidative damage
Polygonum aviculare extract · Toxicology and Applied Pharmacology, 2013Final report on the safety assessment of BHT(1)
Butylated hydroxytoluene · International Journal of Toxicology, 2002Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo
Sodium ascorbyl phosphate ascorbic acid, Ascorbic acid ascorbyl tetraisopalmitate, Acerola extract, Ascorbic acid sodium ascorbyl phosphate, Ascorbic acid activ cg, Vitamin c derivative, Vitamin c complex · Experimental Dermatology, 2003Nicotinic acid/niacinamide and the skin
Niacin · Journal of Cosmetic Dermatology, 2004Lactobacillus reuteri DSM 17938-A comparative study on the effect of probiotics and lysates on human skin
Live probiotic · Experimental Dermatology, 2019Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Ascorbic acid, Tocopherol, Tocopherol vitamin e, I-ascorbic acid, Ascorbic acid powder, Vitamins c, D-alpha tocopheryl vitamin e, Ascorbic acid active vitamin c · Journal of Cosmetic Dermatology, 2020A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation
Ferulic acid · Journal of the American Academy of Dermatology, 2008Dermato-protective properties of ergothioneine through induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated Human keratinocytes
Ergothioneine · Free Radical Biology & Medicine, 2015Linoleic acid and alpha-linolenic acid lightens ultraviolet-induced hyperpigmentation of the skin
Omega 3 · Archives of Dermatological Research, 1998Biological effects of rutin on skin aging
Glucosylrutin · International Journal of Molecular Medicine, 2016Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin
Phloretin, Ferulic acid · Journal of Cosmetic Dermatology, 2008Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo
Acetyl cysteine · The Journal of Investigative Dermatology, 2003The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study
Melaleuca alternifolia tree oil leaf, Melaleuca alternifolia tree leaf extract, Melaleuca alternifolia oil leaf, 4-terpineol, Melaleuca alternifolia tree extract · Indian Journal of Dermatology, Venereology and Leprology, 2007Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics
Collagen, Water-soluble collagen · Dermatology Practical & Conceptual, 2022Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo
Retinol · International Journal of Cosmetic Science, 2017Effects of menthol and cold on histamine-induced itch and skin reactions in man
Menthol, Peppermint leaf extract · Neuroscience Letters, 1995Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin
Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005Molecular mechanisms underlying wound healing and anti-inflammatory properties of naturally occurring biotechnologically produced phenylpropanoid glycosides
Buddleja davidii meristem cell culture · Cellular and Molecular Biology, 2007Psychophysical study of the effects of topical application of menthol in healthy volunteers
Menthol · Pain, 2006Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles
Gold · The Journal of Investigative Dermatology, 2015Combination of microneedling and glycolic acid peels for the treatment of acne scars in dark skin
Saccharum officinarum extract extrait de canne à sucre extract · Journal of Cosmetic Dermatology, 2011Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care
Ubiquinone · BioFactors, 2008Epidermal growth factor and keratinocyte growth factor differentially regulate epidermal migration, growth, and differentiation
Kgf barley sh-polypeptide-3 · Wound Repair and Regeneration, 2000The Effect of Lactobacillus plantarum Extracellular Vesicles from Korean Women in Their 20s on Skin Aging
Live probiotic · Current Issues in Molecular Biology, 2022Tea tree oil reduces histamine-induced skin inflammation
Melaleuca alternifolia tree leaf extract · The British Journal of Dermatology, 2002Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
Retinol, Bakuchiol, Phyto-retinol, Retinol vitamin a · The British Journal of Dermatology, 2019Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin
Scutellaria baicalensis root extract, Baicalin · Journal of Drugs in Dermatology, 2014Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo
Ascorbyl glucoside, Sodium ascorbyl phosphate ascorbic acid, Ascorbic acid ascorbyl tetraisopalmitate, Acerola fruit extract, L-ascorbic acid 2-glucoside, Vitamin c derivative, Vitamin c complex · Journal of Periodontology, 2009Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes
Phenylethyl resorcinol · Asian Journal of Pharmaceutical Sciences, 2018Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression
5 peptide complex, Triple peptide blend, Multi-peptides, Advanced peptide complex, Complex of 21 peptides · International Journal of Molecular Sciences, 2019Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
Panax ginseng root extract · Journal of Ginseng Research, 2017The effects of onion extract on hypertrophic and keloid scars
Onion bulb extract · Journal of Wound Care, 2007Antioxidant and Moisturizing Properties of Carboxymethyl Chitosan with Different Molecular Weights
Chitosan · Polymers, 2020In vitro evaluation of Spirulina platensis extract incorporated skin cream with its wound healing and antioxidant activities
Spirulina platensis extract · Pharmaceutical Biology, 2017Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women
Glutathione · Clinical, Cosmetic and Investigational Dermatology, 2014Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo
Sodium lauryl sulfate · The Journal of Investigative Dermatology, 2008Lactate triggers KAT8-mediated LTBP1 lactylation at lysine 752 to promote skin rejuvenation by inducing collagen synthesis in fibroblasts
Lactic acid · International Journal of Biological Macromolecules, 2024Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced Skin Inflammation and Oxidative Stress in Mice
Grapefruit seed extract · PloS One, 2016Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo
Chamomile, Chamomile extract · International Journal of Molecular Medicine, 2016Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract
Madecassoside, Centella asiatica extract, Centella asiatica, Madecassic acid, Asiaticoside, Centella asiatica leaf water, Centella asiatica stem extract flower leaf · Indian Journal of Pharmaceutical Sciences, 2016Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling
Panax ginseng root extract · Journal of Ethnopharmacology, 2007Topical delivery of tetrahydrocurcumin lipid nanoparticles effectively inhibits skin inflammation: in vitro and in vivo study
Tetrahydrodiferuloylmethane · Drug Development and Industrial Pharmacy, 2018The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy
Centella asiatica extract, Centella asiatica leaf water · Pharmaceutics, 2024Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation
Carica papaya fruit extract · The Journal of Investigative Dermatology, 2015Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin
Squalane · Scientific Reports, 2020Resveratrol as a Multifunctional Topical Hypopigmenting Agent
Resveratrol · International Journal of Molecular Sciences, 2019Effect of fermentation time on the content of bioactive compounds with cosmetic and dermatological properties in Kombucha Yerba Mate extracts
Saccharomyces xylinum black tea ferment · Scientific Reports, 2021Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects
Ubiquinone · BioFactors, 2015An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate to severe acne vulgaris: assessment of efficacy and safety in 2813 patients
Clindamycin phosphate · Journal of the American Academy of Dermatology, 2008Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Melaleuca alternifolia tree oil leaf, Aloe barbadensis leaf juice, Melaleuca alternifolia oil leaf, Aloe barbadensis leaf extract, Melaleuca alternifolia tree leaf extract, Aloe barbadensis leaf, Propolis extract, Aloe barbadensis juice, Aloe barbadensis extract, 4-terpineol, Aloe barbadensis, Melaleuca alternifolia tree extract, Aloe barbadensis gel · Clinical Pharmacology, 2018Use of Collagen in Cosmetic Products
Collagen, Water-soluble collagen · Current Issues in Molecular Biology, 2024A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin
Camellia sinensis · The Journal of Investigative Dermatology, 2019Antioxidant properties evaluation of topical astaxanthin formulations as anti-aging products
Algae extract · Journal of Cosmetic Dermatology, 2019Urea: a comprehensive review of the clinical literature
Urea · Dermatology Online Journal, 2013Topical benzoyl peroxide for acne
Benzoyl peroxide, Benzoyl peroxide 25mg g · The Cochrane Database of Systematic Reviews, 2020Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin
Ceramide, Ceramides, Sphingolipids · Scientific Reports, 2022Effect of Camellia japonica oil on human type I procollagen production and skin barrier function
Camellia japonica flower extract · Journal of Ethnopharmacology, 2007Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery
Liposome formula · Colloids and Surfaces. B, Biointerfaces, 2020Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A
Glycyrrhiza inflata root extract · Journal of the European Academy of Dermatology and Venereology, 2016The safety and efficacy of bacterial nanocellulose wound dressing incorporating sericin and polyhexamethylene biguanide: in vitro, in vivo and clinical studies
Hydrolyzed sericin · Archives of Dermatological Research, 2016Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial
Melatonin · Clinical, Cosmetic and Investigational Dermatology, 2018Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin
Glyceryl glucoside, Glucosides · Skin Pharmacology and Physiology, 2012Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study
Ascorbic acid, Ascorbic acid active vitamin c · Clinical Oral Investigations, 2021Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne
Tretinoin · Clinical, Cosmetic and Investigational Dermatology, 2020Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications
Phenylethyl resorcinol · BioMed Research International, 2017Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin
Ceramide np, Ceramide eop, Ceramide 1 · International Journal of Dermatology, 2008Pterostilbene Attenuates Particulate Matter-Induced Oxidative Stress, Inflammation and Aging in Keratinocytes
Blueberry fruit extract · Antioxidants, 2021Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin
Xylitol, Xylitylglucoside · Acta Dermato-venereologica, 2017Anti-acne vulgaris effects of chlorogenic acid by anti-inflammatory activity and lipogenesis inhibition
Honeysuckle leaf extract · Experimental Dermatology, 2021Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Ascorbic acid, Tocopherol, Ferulic acid, Tocopherol vitamin e, I-ascorbic acid, Ascorbic acid powder, Vitamins c, Ascorbic acid active vitamin c · Journal of Cosmetic Dermatology, 2020Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: a prospective randomized, double blinded, controlled trial
Onion bulb extract · International Wound Journal, 2012Epilobium angustifolium extract demonstrates multiple effects on dermal fibroblasts in vitro and skin photo-protection in vivo
Epilobium angustifolium · General Physiology and Biophysics, 2013Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo
Licorice root extract, Glycyrrhiza glabra root extract licorice root extract, Licorice root, Glycyrrhiza glabra root extract, Glycyrrhiza glabra licorice root extract · Experimental Dermatology, 2015Efficacy of probiotic-derived lotion from Lactobacillus paracasei MSMC 39-1 in mild to moderate acne vulgaris, randomized controlled trial
Lactobacillus · Journal of Cosmetic Dermatology, 2022Injectable thermo-sensitive and wide-crack self-healing hydrogel loaded with antibacterial anti-inflammatory dipotassium glycyrrhizate for full-thickness skin wound repair
Dipotassium glycyrrhizate · Acta Biomaterialia, 2022A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations
Arbutin · Journal of Cosmetic Dermatology, 2015Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study
Retinyl palmitate, Retinyl palmitate vitamin a · International Journal of Nanomedicine, 2021Efficacy of topical silicone gel in scar management: A systematic review and meta-analysis of randomised controlled trials
Polysiloxanes · International Wound Journal, 2020Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation
Hydroxyresveratrol · Food and Chemical Toxicology, 2011Clinical Studies on Topical Curcumin
Curcuma kwangsiensis extract · Skin Pharmacology and Physiology, 2023Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls
Camellia sinensis leaf extract · Experimental Dermatology, 2009Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration
Oil tree, Argania spinosa kernel oil · International Journal of Nanomedicine, 2014Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris
Azelaic acid · Pharmaceutics, 2021Effectiveness of onion extract gel on surgical scars in asians
Onion bulb extract · Dermatology Research and Practice, 2012Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy
Resveratrol, Trans-resveratrol · Molecules, 2023Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin
Centella asiatica leaf extract · Experimental Dermatology, 2008Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin
Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2015Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract
Punica granatum seed oil · Drug Design, Development and Therapy, 2017Role of Resveratrol in Regulating Cutaneous Functions
Resveratrol · Evidence-based Complementary and Alternative Medicine, 2020A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin
Niacin, Myristyl nicotinate · Experimental Dermatology, 2007Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study
Melaleuca alternifolia tree oil leaf, Melaleuca alternifolia oil leaf, 4-terpineol · Dermatology, 2014The clinical effect of glutathione on skin color and other related skin conditions: A systematic review
Glutathione · Journal of Cosmetic Dermatology, 2019Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine
Evodia rutaecarpa fruit extract · Journal of Dermatological Science, 2006The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle
Thioctic acid · European Journal of Pharmaceutics and Biopharmaceutics, 2014The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin, Madecassoside, Madecassic acid, Concentrated glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial
Madecassoside, Madecassic acid, Asiaticoside, Centella asiatica leaf water · Journal of Alternative and Complementary Medicine, 2020Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide, Gentlebright complex · Journal of Cosmetic Dermatology, 2021Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison
Adapalene usp retinoid acne treatment, Adapalene, Adapalene retinoid · American Journal of Clinical Dermatology, 2018Benzoyl peroxide treatment decreases Cutibacterium acnes in shoulder surgery, from skin incision until wound closure
Benzoyl peroxide, Benzoyl peroxide 25mg g · Journal of Shoulder and Elbow Surgery, 2021Protective effects of a new phloretin derivative against UVB-induced damage in skin cell model and human volunteers
Phloretin · International Journal of Molecular Sciences, 2014Skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) incorporated into hydrogel
Ascorbyl palmitate · Die Pharmazie, 2005α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis
Palmitoyl grapevine shoot extract · Theranostics, 2018Niacinamide mitigates SASP-related inflammation induced by environmental stressors in human epidermal keratinocytes and skin
Gentlebright complex · International Journal of Cosmetic Science, 2020Old Plant, New Possibilities: Wild Bilberry (Vaccinium myrtillus L., Ericaceae) in Topical Skin Preparation
Vaccinium myrtillus leaf extract fruit · Antioxidants, 2021Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling
Leontopodium alpinum extract, Leontopodium alpinum meristem cell culture · Genes, 2020Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug
Adapalene, Adapalene usp retinoid acne treatment, Benzoyl peroxide, Clindamycin, Benzoyl peroxide 25mg g, Adapalene retinoid, Clindamycin phosphate · American Journal of Clinical Dermatology, 2022Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine
Acetyl glucosamine, N-acetyl glucosamine nag · Journal of Cosmetic Dermatology, 2007Synergism of plant extract and vegetable oils-based lipid nanocarriers: Emerging trends in development of advanced cosmetic prototype products
Daucus carota sativa root extract carrot root extract, Extract · Materials Science & Engineering. C, Materials for Biological Applications, 2020Cytotoxicity of lecithin-based nanoemulsions on human skin cells and ex vivo skin permeation: Comparison to conventional surfactant types
Hydrogenated lecithin · International Journal of Pharmaceutics, 2019Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial
Acetyl glucosamine, N-acetyl glucosamine nag · The British Journal of Dermatology, 2010Effective reduction of post-inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido-thiazolyl-resorcinol (Thiamidol)
Isobutylamido thiazolyl resorcinol, Isobutylamido thiazolyl resorcinol thiamidol · International Journal of Cosmetic Science, 2021Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study
Isobutylamido thiazolyl resorcinol · International Journal of Cosmetic Science, 2020Resveratrol as a factor preventing skin aging and affecting its regeneration
Resveratrol · Postepy Dermatologii I Alergologii, 2022Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells
Leontopodium alpinum meristem cell culture · Mediators of Inflammation, 2012Encapsulation and controlled release of retinol from silicone particles for topical delivery
Encapsulated retinol, Advanced retinol · Journal of Controlled Release, 2018In vitro antioxidant, collagenase inhibition, and in vivo anti-wrinkle effects of combined formulation containing Punica granatum, Ginkgo biloba, Ficus carica, and Morus alba fruits extract
Ginkgo biloba leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2015Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties
Algae extract · Journal of Cosmetic Science, 2002The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-8, Acetyl hexapeptide-3, Hexapeptide · American Journal of Clinical Dermatology, 2013A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen
Retinyl propionate · The British Journal of Dermatology, 2010Two superior antioxidants: Ferulic acid and ascorbic acid in reducing signs of photoaging-A split-face comparative study
Sodium ascorbyl phosphate ascorbic acid, Acerola fruit extract, Acerola extract · Dermatologic Therapy, 2022Evaluation of Cosmetic and Dermatological Properties of Kombucha-Fermented Berry Leaf Extracts Considered to Be By-Products
Saccharomyces xylinum black tea ferment · Molecules, 2022Protective effects of Camellia japonica flower extract against urban air pollutants
Camellia japonica flower extract · BMC Complementary and Alternative Medicine, 2019Development of Polymeric Micelles of Oleanolic Acid and Evaluation of Their Clinical Efficacy
Oleanolic acid · Nanoscale Research Letters, 2020Human skin penetration and local effects of topical nano zinc oxide after occlusion and barrier impairment
Calamine · European Journal of Pharmaceutics and Biopharmaceutics, 2016A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid, Decylene glycol, Glycyrrhiza inflata root extract · BioMed Research International, 2020A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol, Panthenol vitamin b5, D-pantothenyl alcohol, Vitamin b5, Panthenol b5 · The Journal of Dermatological Treatment, 2017Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation
Tocopheryl acetate, Tocopheryl acetate vitamin e derivative · Urologia Internationalis, 2019Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide · Scientific Reports, 2024Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy
Extracts flower · Phytotherapy Research, 2011Topical ivermectin-metronidazole gel therapy in the treatment of blepharitis caused by Demodex spp.: A randomized clinical trial
Ivermectin · Contact Lens & Anterior Eye, 2021Collagen peptides affect collagen synthesis and the expression of collagen, elastin, and versican genes in cultured human dermal fibroblasts
Collagen peptides · Frontiers in Medicine, 2024Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage
Dimethylmethoxy chromanol · European Journal of Pharmaceutical Sciences, 2017Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study
Glycolic acid, Saccharum officinarum extract extrait de canne à sucre extract · Journal of Cosmetic Dermatology, 2019Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-beta-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin(R))
Boswellia serrata extract · Toxicology Mechanisms and Methods, 2006Formulation and evaluation on human skin of a water-in-oil emulsion containing Muscat hamburg black grape seed extract
Vitis vinifera seed extract grape seed extract · International Journal of Cosmetic Science, 2015High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde
Menthol · The Journal of Pain, 2016In vitro, ex vivo, and clinical evaluation of anti-aging gel containing EPA and CBD
Cannabidiol · Journal of Cosmetic Dermatology, 2023A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial
Melaleuca alternifolia tree oil leaf, Adapalene, Adapalene usp retinoid acne treatment, Melaleuca alternifolia tree leaf extract, 4-terpineol, Adapalene retinoid, Melaleuca alternifolia tree extract · Archives of Dermatological Research, 2022Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration
Adenosine · International Journal of Cosmetic Science, 2018A Dunaliella salina Extract Counteracts Skin Aging under Intense Solar Irradiation Thanks to Its Antiglycation and Anti-Inflammatory Properties
Dunaliella salina extract · Marine Drugs, 2022Fermented pomegranate extracts protect against oxidative stress and aging of skin
Punica granatum extract, Punica granatum fruit extract · Journal of Cosmetic Dermatology, 2022Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes
Collagen peptides · Nutrients, 2022Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system
Retinyl palmitate · Colloids and Surfaces. B, Biointerfaces, 2011Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris
Mandelic acid · Journal of Cosmetic Dermatology, 2020Effects of lecithin-based nanoemulsions on skin: Short-time cytotoxicity MTT and BrdU studies, skin penetration of surfactants and additives and the delivery of curcumin
Hydrogenated lecithin · International Journal of Pharmaceutics, 2020Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin
Thioctic acid · The British Journal of Dermatology, 2003Safflower Seed Oil and Its Active Compound Acacetin Inhibit UVB-Induced Skin Photoaging
Carthamus tinctorius seed oil · Journal of Microbiology and Biotechnology, 2020Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide
Glyceryl glucoside, Glucosides · The Journal of Clinical and Aesthetic Dermatology, 2012A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face
Hexapeptide · Journal of Cosmetic Dermatology, 2017Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days
Tetrahexyldecyl ascorbate, Ascorbyl tetraisopalmitate, Vitamin c tetraisopalmitate · Journal of Cosmetic Dermatology, 2019The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Gluconolactone, Glycyrrhiza inflata root extract, Glycolic acid, Pha polyhydroxy acid · Clinical, Cosmetic and Investigational Dermatology, 2019Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
Allantoin, Panthenol, D-pantothenyl alcohol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020Topical glutathione amino acid precursors protect skin against environmental and oxidative stress
Glutathione · Journal of the European Academy of Dermatology and Venereology, 2024Efficacy assessments of tretinoin-loaded nano lipid carriers in acne vulgaris: a double blind, split-face randomized clinical study
Tretinoin · Archives of Dermatological Research, 2022Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials
Tretinoin · International Journal of Women's Dermatology, 2022Evaluation of anti-acne properties of phloretin in vitro and in vivo
Phloretin · International Journal of Cosmetic Science, 2016An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects
Blueberry fruit extract · Clinical, Cosmetic and Investigational Dermatology, 2020Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study
Ascorbyl tetraisopalmitate, Tetrahexyldecyl ascorbate, Vitamin c derivative, Vitamin c tetraisopalmitate · Photochemistry and Photobiology, 2021High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin
Witch hazel extract, Witch hazel water, Witch hazel · Phytochemistry, 2001Development of Multifunctional Cosmetic Cream Using Bioactive Materials from Streptomyces sp. T65 with Synthesized Mesoporous Silica Particles SBA-15
Silicon dioxide · Antioxidants, 2020Alginate dressing and polyurethane film versus paraffin gauze in the treatment of split-thickness skin graft donor sites: a randomized controlled pilot study
Polyurethane film · Advances in Skin & Wound Care, 2013Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin
Vitamin e tocotrienol, Tocotrienols · Free Radical Biology & Medicine, 2003Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts
Hexapeptide-11 · Redox Biology, 2015Snail Slime Extracted by a Cruelty Free Method Preserves Viability and Controls Inflammation Occurrence: A Focus on Fibroblasts
Snail mucin · Molecules, 2023Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-8, Acetyl hexapeptide-3, Hexapeptide · Annals of Dermatology, 2019Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy
Madecassoside, Centella asiatica extract, Centella asiatica, Centella asiatica leaf extract, Centella asiatica leaf water, Centella asiatica stem extract flower leaf · Molecules, 2023In vivo anti-ageing activity of cream containing niosomes loaded with purple glutinous rice (Oryza sativa Linn.) extract
Rice extract lees extract, Rice extract · International Journal of Cosmetic Science, 2020Characterization of Acne-Prone Skin with Reflectance Confocal Microscopy and Optical Coherence Tomography and Modifications Induced by Topical Treatment and Probiotic Supplementation
Hydroxypinacolone retinoate · Journal of Clinical Medicine, 2023A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne
Gluconolactone, Pha polyhydroxy acid · The Australasian Journal of Dermatology, 1992Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin
Glucosyl hesperidin · Biomolecules & Therapeutics, 2013In vivo skin irritation potential of a Castanea sativa (Chestnut) leaf extract, a putative natural antioxidant for topical application
Chestnut leaf extract · Basic & Clinical Pharmacology & Toxicology, 2008Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways
Tremella fuciformis sporocarp extract · Journal of Cosmetic Dermatology, 2021Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula
Galactomyces ferment filtrate, Rice ferment filtrate, Saccharomyces ferment filtrate, Pitera, Sk-ii pitera concentrate · Journal of Clinical Medicine, 2021Double-blind, randomized, placebo-controlled study of a lotion containing triethyl citrate and ethyl linoleate in the treatment of acne vulgaris
Ethyl linoleate, Triethyl citrate · The British Journal of Dermatology, 2007Efficacy of olive leaf extract-containing cream for facial rejuvenation: A pilot study
Olea europaea leaf extract olive leaf extract, Olea europaea leaf extract, Olea europaea olive leaf extract · Journal of Cosmetic Dermatology, 2020Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging
1, Phyllanthus emblica fruit extract · Journal of Traditional and Complementary Medicine, 2021Allergy to oxidized limonene and linalool is frequent in the U.K
Linalool, Limonene · The British Journal of Dermatology, 2014Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid, Energy complex · Journal of Cosmetic Dermatology, 2024The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro
Bifida lysate ferment · Journal of Cosmetic Dermatology, 2023Night Cream Containing Melatonin, Carnosine and Helichrysum italicum Extract Helps Reduce Skin Reactivity and Signs of Photodamage: Ex Vivo and Clinical Studies
Helichrysum italicum oil flower, Helichrysum italicum extract, Carnosine · Dermatology and Therapy, 2020Tocotrienol-rich fraction attenuates UV-induced inflammaging: A bench to bedside study
Tocotrienols, Vitamin e tocotrienol · Journal of Cosmetic Dermatology, 2018Comparative Study of 35% Glycolic Acid, 20% Salicylic-10% Mandelic Acid, and Phytic Acid Combination Peels in the Treatment of Active Acne and Postacne Pigmentation
Rice bran extract, Phytic acid · Journal of Cutaneous and Aesthetic Surgery, 2019Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects
Vitamin e · Journal of Cosmetic Dermatology, 2020An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells
Rubus idaeus leaf extract raspberry leaf extract · International Journal of Cosmetic Science, 2015Genistein protects against ultraviolet B-induced wrinkling and photoinflammation in in vitro and in vivo models
Soy isoflavones · Genes & Nutrition, 2022High-Payload Nanosuspension of Centella asiatica Extract for Improved Skin Delivery with No Irritation
Asiaticoside, Madecasic acid · International Journal of Nanomedicine, 2021Inhibition of TRPV1 prevented skin irritancy induced by phenoxyethanol. A preliminary in vitro and in vivo study
Phenoxyethanol · International Journal of Cosmetic Science, 2017Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)
Vitamin e tocotrienol, Tocotrienols · Journal of the European Academy of Dermatology and Venereology, 2012Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach
Zinc, Zinc oxide, Calamine · Journal of Controlled Release, 2025Grape-Derived Exosome-Like Nanovesicles Effectively Ameliorate Skin Photoaging by Protecting Epithelial Cells
Vitis vinifera flower cell extract grape flower cell extract · Journal of Food Science, 2025Tremella fuciformis Inhibits Melanogenesis in B16F10 Cells and Promotes Migration of Human Fibroblasts and Keratinocytes
Tremella fuciformis sporocarp extract silver ear mushroom extract · In Vivo, 2022Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function
Rosmarinus officinalis leaf extract · International Journal of Molecular Sciences, 2022Effects of seaweed Laminaria japonica extracts on skin moisturizing activity in vivo
Laminaria japonica extract · Journal of Cosmetic Science, 2013Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications
Matrixyl 3000, Palmitoyl tripeptide-1 acetate, Palmitoyl hexapeptide-12, Palmitoyl tetrapeptide-7, 5 peptide complex, Palmitoyl oligopeptide, Palmitoyl tripeptide-1, Triple peptide blend · Journal of Cosmetic Dermatology, 2015A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid
Ceramide np, 3 essential ceramides · Skin Pharmacology and Physiology, 2022Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of Schisandra chinensis Extracts and Their Applicability in Skin Care Product
Schisandra chinensis fruit extract · Molecules, 2022Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol
Hexylresorcinol · Journal of Drugs in Dermatology, 2016Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
Sodium ascorbyl phosphate · International Journal of Cosmetic Science, 2009Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study
Jojoba seed oil, Jojoba oil · Forschende Komplementarmedizin, 2012Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection
Silicon dioxide · Heliyon, 2020Improvement of hydration and epidermal barrier function in human skin by a novel compound isosorbide dicaprylate
Isosorbide dicaprylate · International Journal of Cosmetic Science, 2017Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine
Sophora angustifolia root extract · European Journal of Pharmaceutical Sciences, 2021Lecithin-based nanoemulsions of traditional herbal wound healing agents and their effect on human skin cells
Hydrogenated lecithin · European Journal of Pharmaceutics and Biopharmaceutics, 2022Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy
Sodium lauryl sulfate · Pharmaceutics, 2021A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid, Energy complex · Journal of Drugs in Dermatology, 2023Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies
Alpha-arbutin, Alpha arbutin · Heliyon, 2023Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial
Lactobacillus centella asiatica extract ferment filtrate, Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs
Pinus pinaster bud extract bark, Vitamin e, Pine extract, Pinus pinaster bark extract · Journal of Cosmetic Dermatology, 2022Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials
Adapalene, Clindamycin, Adapalene retinoid, Clindamycin phosphate · Journal of the American Academy of Dermatology, 2023Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris
Azelaic acid · Dermatology and Therapy, 2024Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection
Xanthan gum, Rice extract · Pharmaceuticals, 2023Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin
Acetyl dipeptide-1 cetyl ester, Neurosensine · Journal of the European Academy of Dermatology and Venereology, 2016Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide
Hexylresorcinol · International Journal of Cosmetic Science, 2022A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial
Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques
Ascorbyl tetraisopalmitate, Tetrahexyldecyl ascorbate, Vitamin c tetraisopalmitate · European Journal of Pharmaceutics and Biopharmaceutics, 2017Semi-Solid Dosage Forms Containing Pranoprofen-Loaded NLC as Topical Therapy for Local Inflammation: In Vitro, Ex Vivo and In Vivo Evaluation
Carbomer 940 · Gels, 2023Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: Results from two phase 3 double-blind, randomized, vehicle-controlled studies
Benzoyl peroxide 25mg g, Benzoyl peroxide · Journal of the American Academy of Dermatology, 2023Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study
1, Fermented · Scientific Reports, 2023The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols
2-hexanediol · International Journal of Cosmetic Science, 2011Colloidal Oatmeal <em>(Avena Sativa)</em> Improves Skin Barrier Through Multi-Therapy Activity
Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2016Exploring the antioxidant potentiality of two food by-products into a topical cream: stability, in vitro and in vivo evaluation
Medicago sativa extract · Drug Development and Industrial Pharmacy, 2016Microwave-assisted and chemically tailored chlorogenic acid-functionalized silver nanoparticles of Citrus sinensis in gel matrix aiding QbD design for the treatment of acne
Chlorogenic acids, Honeysuckle leaf extract · Journal of Cosmetic Dermatology, 2023Ergothioneine-Sodium Hyaluronate Dressing: A Promising Approach for Protecting against Radiation-Induced Skin Injury
Ergothioneine · ACS Applied Materials & Interfaces, 2024Topical application of superoxide dismutase mediated by HIV-TAT peptide attenuates UVB-induced damages in human skin
Superoxide dismutase · European Journal of Pharmaceutics and Biopharmaceutics, 2016Chemical peels for acne vulgaris: a systematic review of randomised controlled trials
Mandelic acid · BMJ Open, 2018Curcumin-Loaded Lipid Nanocarriers: A Targeted Approach for Combating Oxidative Stress in Skin Applications
Curcuma kwangsiensis extract · Pharmaceutics, 2025Topical nanoencapsulated cannabidiol cream as an innovative strategy combating UV-A-induced nuclear and mitochondrial DNA injury: A pilot randomized clinical study
Cannabidiol · Journal of the American Academy of Dermatology, 2024Preparation and evaluation of benzalkonium chloride hand sanitizer as a potential alternative for alcohol-based hand gels
Benzalkonium chloride · Saudi Pharmaceutical Journal, 2021Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study
Zinc gluconate · Clinical, Cosmetic and Investigational Dermatology, 2023Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model
Hydrogenated jojoba oil, Jojoba seed oil · Frontiers in Pharmacology, 2024Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function
Propanediol, 3-butylene glycol · International Journal of Cosmetic Science, 2024Safety and efficacy of Sclerocarya birrea (A.Rich.) Hochst (Marula) oil: A clinical perspective
Sclerocarya birrea seed oil · Journal of Ethnopharmacology, 2015Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations
Vitamin e · Journal of Cosmetic Dermatology, 2022A novel model of inflammatory pain in human skin involving topical application of sodium lauryl sulfate
Sodium lauryl sulfate · Inflammation Research, 2010Evaluating the Safety and Efficacy of a Topical Formulation Containing Epidermal Growth Factor, Tranexamic Acid, Vitamin C, Arbutin, Niacinamide and Other Ingredients as Hydroquinone 4% Alternatives to Improve Hyperpigmentation: A Prospective, Randomized, Controlled Split Face Study
Arbutin, Alpha arbutin · Journal of Cosmetic Science, 2020Topical delivery of extracted curcumin as curcumin loaded spanlastics anti-aging gel: Optimization using experimental design and ex-vivo evaluation
Hydroxypropyl methylcellulose · Saudi Pharmaceutical Journal, 2024Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial
Zinc pca · The Journal of Clinical and Aesthetic Dermatology, 2020Challenging the safety and efficacy of topically applied chlorogenic acid, apigenin, kaempferol, and naringenin by HET-CAM, HPLC-TBARS-EVSC, and laser Doppler flowmetry
Grapefruit fruit extract, Naringenin, Grapefruit seed extract, Honeysuckle leaf extract, Grapefruit extract · Frontiers in Chemistry, 2024A clinicopathological study of the effects of topical retinyl propionate cream in skin photoageing
Retinyl propionate · Clinical and Experimental Dermatology, 1998Cichorium intybus root extract: A "vitamin D-like" active ingredient to improve skin barrier function
Cichorium intybus leaf extract · The Journal of Dermatological Treatment, 2017Is benzyl alcohol a significant contact sensitizer?
Benzyl alcohol · Journal of the European Academy of Dermatology and Venereology, 2022Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract
Camellia sinensis leaf extract, Camellia sinensis leaf water, Aloe barbadensis flower extract, Black tea extract · Clinical, Cosmetic and Investigational Dermatology, 2019Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Capryloyl salicylic acid, Citric acid, Hydroxyethylpiperazine ethane sulfonic acid, Hepes · Journal of Cosmetic Dermatology, 2021Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System
3-o-ethyl ascorbic acid ascorbic acid, Ethyl ascorbic acid ascorbic acid · Pharmaceutics, 2023Whitening effect of alpha-bisabolol in Asian women subjects
Bisabolol, Bisabolol l-alpha, Alpha-bisabolol · International Journal of Cosmetic Science, 2010The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study
Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study
Acetyl hexapeptide-8, Acetyl hexapeptide-3, Tripeptide-10 citrulline · Journal of Cosmetic Dermatology, 2017Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane
Cyclopentasiloxane · International Journal of Toxicology, 2011Lycopene and Melatonin: Antioxidant Compounds in Cosmetic Formulations
Solanum lycopersicum fruit extract tomato fruit extract · Skin Pharmacology and Physiology, 2020Formulation and evaluation of antisebum secretion effects of sea buckthorn w/o emulsion
Hippophae rhamnoides fruit extract · Journal of Pharmacy & Bioallied Sciences, 2010Randomized double-blind vehicle controlled study of the effects of topical acetyl zingerone on photoaging
Acetyl zingerone · Journal of Cosmetic Dermatology, 2021In Vitro and Clinical Safety Assessment of the Multiple W/O/W Emulsion Based on the Active Ingredients from Rosmarinus officinalis L., Avena sativa L. and Linum usitatissimum L
Avena sativa kernel extract oat kernel extract, Rosemary leaf extract · Pharmaceutics, 2021New clinical approach in facial mild-moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex
Succinic acid · Journal of Cosmetic Dermatology, 2024Reduction in the appearance of facial hyperpigmentation by topical N-undecyl-10-enoyl-L-phenylalanine and its combination with niacinamide
Undecylenoyl phenylalanine · Journal of Cosmetic Dermatology, 2009Naringenin, a flavanone constituent from Sea buckthorn pulp extract, prevents ultraviolet (UV)-B radiation-induced skin damage via alleviation of impaired mitochondrial dynamics mediated inflammation in human dermal fibroblasts and Balb/c mice models
Naringenin · Journal of Photochemistry and Photobiology. B, Biology, 2024Evaluation of moisturizing and irritation potential of sacha inchi oil
Plukenetia volubilis seed oil · Journal of Cosmetic Dermatology, 2020Application of a combined sulphorhodamine B and melanin assay to the evaluation of Chinese medicines and their constituent compounds for hyperpigmentation treatment
4-ethylresorcinol · Journal of Ethnopharmacology, 2010Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters
Ectoin · Journal of Cosmetic Dermatology, 2024Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison
Willow bark extract · Journal of Cosmetic Dermatology, 2019Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract
Willow bark extract · Planta Medica, 2019An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging
Willow bark extract · Journal of Cosmetic Dermatology, 2010'All-natural' anti-wrinkle emulsion serum with Acmella oleracea extract: A design of experiments (DoE) formulation approach, rheology and in vivo skin performance/efficacy evaluation
Acmella oleracea extract, Spilanthol · International Journal of Cosmetic Science, 2021Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging
Schisandra chinensis fruit extract · International Journal of Molecular Sciences, 2018The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging
Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study
Beta-glucan · Journal of Cosmetic Dermatology, 2021Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers
Sodium ascorbyl phosphate, Ascorbyl palmitate · Drug Research, 2017Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects
Punica granatum extract · Postepy Dermatologii I Alergologii, 2014Assessment of Cosmetic and Dermatological Properties and Safety of Use of Model Skin Tonics with Kombucha-Fermented Red Berry Extracts
Saccharomyces xylinum black tea ferment · International Journal of Molecular Sciences, 2022A Multi-center Trial Evaluating a Serum Comprised of Plant-based Adaptogens Targeting Skin Quality
Adaptogens · The Journal of Clinical and Aesthetic Dermatology, 2024Inhibitory effects of shell of Camellia oleifera Abel extract on mushroom tyrosinase and human skin melanin
Butylene glycol · Journal of Cosmetic Dermatology, 2019Effects of vitamin C on dark circles of the lower eyelids: quantitative evaluation using image analysis and echogram
Sodium ascorbate · Skin Research and Technology, 2009Whitening effect of kojic acid dipalmitate loaded nanosized ethosomal gel for the treatment of hyperpigmentation: In vitro and in vivo characterization
Kojic acid dipalmitate, Kojic dipalmitate · Journal of Cosmetic Dermatology, 2022Comparative benefit of two thermal spring waters after photodynamic therapy procedure
Avène thermal spring water · Journal of Cosmetic Dermatology, 2007Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin
Capryloyl salicylic acid · Journal of Cosmetic Dermatology, 2008Annurca Apple Oleolite as Functional Ingredient for the Formulation of Cosmetics with Skin-Antiaging Activity
1 · International Journal of Molecular Sciences, 2024A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines
Undecylenoyl phenylalanine · Clinical and Experimental Dermatology, 2010Neuroimmunomodulatory compound for sensitive skin care: in vitro and clinical assessment
Carnosine · Journal of Cosmetic Dermatology, 2008Assessment of cubosomal alpha lipoic acid gel efficacy for the aging face: a single-blinded, placebo-controlled, right-left comparative clinical study
Thioctic acid · Journal of Cosmetic Dermatology, 2017Apple Extract (Malus sp.) and Rutin as Photochemopreventive Agents: Evaluation of Ultraviolet B-Induced Alterations on Skin Biopsies and Tissue-Engineered Skin
Pyrus malus fruit extract · Rejuvenation Research, 2020Tolerance and efficacy of a product containing ellagic and salicylic acids in reducing hyperpigmentation and dark spots in comparison with 4% hydroquinone
Pomegranate pericarp extract · Journal of Drugs in Dermatology, 2013Efficacy and safety of a new topical gel formulation containing retinol encapsulated in glycospheres and hydroxypinacolone retinoate, an antimicrobial peptide, salicylic acid, glycolic acid and niacinamide for the treatment of mild acne: preliminary results of a 2-month prospective study
Granactive retinoid · Giornale Italiano Di Dermatologia E Venereologia, 2020In vivo spectrophotometric evaluation of skin barrier recovery after topical application of soybean phytosterols
Phytosterols · Journal of Cosmetic Science, 2008Exploring the Therapeutic Potential of Green Tea (Camellia sinensis L.) in Anti-Aging: A Comprehensive Review of Mechanisms and Findings
Camellia sinensis extract · Mini Reviews in Medicinal Chemistry, 2025Topical manganese peptide in the treatment of photodamaged skin
Complex of 21 peptides · Journal of Cosmetic and Laser Therapy, 2007Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders
3-o-ethyl ascorbic acid, Ethyl ascorbyl ether, 2-o-ethyl ascorbic acid, Ethyl ascorbic acid vc · Polymers, 2023Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
Adenosine · Journal of Cosmetic Dermatology, 2019Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast
Squalane · Molecules, 2025Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment
Lactobacillus centella asiatica extract ferment filtrate, Centella asiatica leaf extract, Asiatic acid · International Journal of Pharmaceutics, 2024Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration
Betaine, Aloe barbadensis flower extract · Molecules, 2024Neryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrier
Helichrysum italicum oil flower · PloS One, 2023Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids
Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine
Acetyl glucosamine, N-acetyl glucosamine nag · Advanced Pharmaceutical Bulletin, 2016Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial
Ferulic acid · The Journal of Dermatological Treatment, 2025Development, Characterization, and Clinical Investigation of a New Topical Emulsion System Containing a Castanea sativa Spiny Burs Active Extract
Chestnut leaf extract · Pharmaceutics, 2021A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric
Astaxanthin powder, Astaxanthin · Journal of Cosmetic Dermatology, 2023Stability, antioxidant activity, in vivo safety and efficacy of creams with standardized wild apple fruit extract: a comparison of conventional and biodegradable emulsifiers
Pyrus malus fruit extract · International Journal of Cosmetic Science, 2019Effect of facial application of essence containing royal jelly extract on stratum corneum moisture content: A placebo-controlled, double-blind, parallel-group study
Royal jelly · Journal of Cosmetic Dermatology, 2022The protective effect of Artemisia Capillaris Thunb. Extract against UVB-induced apoptosis and inflammation through inhibiting the cGAS/STING pathway
Artemisia capillaris flower extract · Journal of Photochemistry and Photobiology. B, Biology, 2024Protective Effects of Soy Oligopeptides in Ultraviolet B-Induced Acute Photodamage of Human Skin
Bio-mimicking peptides · Oxidative Medicine and Cellular Longevity, 2016Action of Mangifera indica Leaf Extract on Acne-Prone Skin through Sebum Harmonization and Targeting C. acnes
Mangifera indica extract pulp, Mangifera indica leaf extract · Molecules, 2022Effects of lactobionic acid peel, aluminum oxide crystal microdermabrasion, and both procedures on skin hydration, elasticity, and transepidermal water loss
Lactobionic acid · Journal of Cosmetic Dermatology, 2019Efficacy of octenidine dihydrochloride and 2-phenoxyethanol in the topical treatment of inflammatory acne
Phenoxyethanol · Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica, 2008Formulation of Ascorbic Acid and Betaine-based Therapeutic Deep Eutectic System for Enhanced Transdermal Delivery of Ascorbic Acid
3-o-ethyl ascorbic acid ascorbic acid, Betaine · Pharmaceutics, 2024Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects
Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025Topical application of highly concentrated water-in-oil emulsions: Physiological skin parameters and skin penetration in vivo - A pilot study
Isopropyl myristate · International Journal of Pharmaceutics, 2019Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis
Yeast extract, Hydrolyzed yeast extract · Journal of Clinical Medicine, 2023Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota
Camellia sinensis leaf extract · Molecules, 2024Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation
Arbutin · Biomaterials Science, 2023An Evaluation of Root Phytochemicals Derived from Althea officinalis (Marshmallow) and Astragalus membranaceus as Potential Natural Components of UV Protecting Dermatological Formulations
Althaea officinalis root extract · Oxidative Medicine and Cellular Longevity, 2016Design and in vivo evaluation of emulgel formulations including green tea extract and rose oil
Rosa damascena oil flower, Rosa damascena oil flower rose oil flower · Acta Pharmaceutica, 2013Clinical and sebumetric evaluation of topical emulsions in the treatment of acne vulgaris
Hippophae rhamnoides fruit extract, Hippophae rhamnoides extract · Postepy Dermatologii I Alergologii, 2014Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres
Papain, Carica papaya fruit extract · Giornale Italiano Di Dermatologia E Venereologia, 2015Skin-Whitening Effect of a Callus Extract of Nelumbo nucifera Isolate Haman
Nelumbo nucifera germ extract · Plants, 2023Panthenyl triacetate transformation, stimulation of metabolic pathways, and wound-healing properties in the human skin
Panthenyl triacetate · Journal of Cosmetic Science, 2012Antimicrobial efficacy of granulysin-derived synthetic peptides in acne vulgaris
Bio-mimicking peptides · International Journal of Dermatology, 2015Effects and Mechanism of the Leontopodium alpinum Callus Culture Extract on Blue Light Damage in Human Foreskin Fibroblasts
Leontopodium alpinum meristem cell culture · Molecules, 2023Research on antioxidant performance of diglucosyl gallic acid and its application in emulsion cosmetics
Diglucosyl gallic acid · International Journal of Cosmetic Science, 2022Evaluation of an SPF50 Sunscreen Containing Photolyase and Antioxidants for its Anti-Photoaging Properties and Photoprotection
Arabidopsis thaliana extract · Journal of Drugs in Dermatology, 2022Safety assessment of a novel water-soluble extract of Boswellia serrata gum resin: acute toxicity, 90-day sub-chronic toxicity, Ames' bacterial reverse mutation, and in vivo micronucleus assays
Boswellia serrata extract · Toxicology Mechanisms and Methods, 2022Topical formulation of a new plant extract complex with refirming properties. Clinical and non-invasive evaluation in a double-blind trial
Extract tree · International Journal of Cosmetic Science, 2000Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda
Mandelic acid · Journal of Cosmetic Dermatology, 2022Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract
Camellia japonica flower extract · FEBS Open Bio, 2021Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin
Copper tripeptide-1 · Archives of Facial Plastic Surgery, 2006Salicyloyl-phytosphingosine: a novel agent for the repair of photoaged skin
Salicyloyl phytosphingosine · International Journal of Cosmetic Science, 2007New topical tranexamic acid derivative for the improvement of hyperpigmentation and inflammation in the sun-damaged skin
Cetyl tranexamate mesylate · Journal of Cosmetic Dermatology, 2021Tandem repeated irritation in aged skin induces distinct barrier perturbation and cytokine profile in vivo
Toluene · The British Journal of Dermatology, 2012Mechanistic studies of anti-hyperpigmentary compounds: elucidating their inhibitory and regulatory actions
4-ethylresorcinol · International Journal of Molecular Sciences, 2014Skin Improvement with Antioxidant Effect of Yuja (Citrus junos) Peel Fractions: Wrinkles, Moisturizing, and Whitening
Citrus junos fruit extract · Antioxidants, 2022Investigating the Anti-Aging Effects of Caviar Oil on Human Skin
Caviar extract · In Vivo, 2023Treatment of Postinflammatory Hyperpigmentation Following Acne With Microneedling and Panax Ginseng-Derived Exosomes
Panax ginseng root extract · Plastic and Reconstructive Surgery. Global Open, 2025Algae extract protection effect on oxidized protein level in human stratum corneum
Algae extract · Annals of the New York Academy of Sciences, 2004Influence of vitamin E acetate on stratum corneum hydration
Tocopheryl acetate, Tocopheryl acetate vitamin e · Arzneimittel-Forschung, 1998Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders
Thymol, Thymus vulgaris extract · International Journal of Pharmaceutics, 2024A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants
Dimethicone · Ostomy/wound Management, 2005The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively
Betaine · Skin Research and Technology, 2003Efficacy of ethyl ascorbyl ether-containing cosmetic cream on blue light-induced skin changes
Ethyl ascorbyl ether · Journal of Cosmetic Dermatology, 2022Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial
Sodium hypochlorite · Dermatology Practical & Conceptual, 2021Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles
Dimethoxytolyl propylresorcinol, Phenylethyl resorcinol · Journal of Cosmetic Dermatology, 2021Therapeutic Efficacy of Bovine Basic Fibroblast Growth Factor Combined with Ultrapulsed Fractional CO2 Laser in Acne Scars: Randomized Controlled Trial
Sh-polypeptide-1 · Clinical, Cosmetic and Investigational Dermatology, 2023Comparative physicochemical stability and clinical anti-wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers
Sodium ascorbyl phosphate · Journal of Cosmetic Dermatology, 2021Development of a cream formulation containing bee venom and other bee products
Royal jelly · Journal of Cosmetic Dermatology, 2022Anatomical site differences of sodium lauryl sulfate-induced irritation: randomized controlled trial
Sodium lauryl sulfate · The British Journal of Dermatology, 2019Topical lycopene emulgel significantly improves biophysical parameters of human skin
Solanum lycopersicum fruit extract tomato fruit extract · European Journal of Pharmaceutics and Biopharmaceutics, 2022Synergistic action of a triple peptide complex on an essential extra-cellular matrix protein exhibits significant anti-aging benefits
5 peptide complex, Triple peptide blend, Advanced peptide complex, Complex of 21 peptides · Journal of Cosmetic Dermatology, 2010Influence of Panax ginseng formulation on skin microbiota: A randomized, split face comparative clinical study
2-hexanediol · Journal of Ginseng Research, 2022Evaluation of wound healing potential of new composite liposomal films containing coenzyme Q10 and d-panthenyl triacetate as combinational treatment
Panthenyl triacetate · Pharmaceutical Development and Technology, 2021Hydrolipidic Characteristics and Clinical Efficacy of a Dermocosmetic Formulation for the Improvement of Homeostasis on Oily Mature Skin
Medicago sativa extract · Life, 2022A new topical biotechnological phytocomplex for truncal mild-moderate acne restores skin microbiota balance
Succinic acid · Skin Research and Technology, 2024Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid
Pha polyhydroxy acid, Lactobionic acid · Journal of Cosmetic Dermatology, 2010A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo
Shea butter, Aloe barbadensis flower extract · Journal of Cosmetic Dermatology, 2022A randomized controlled study to evaluate the depigmenting activity of L-ascorbic acid plus phytic acid-serum vs. placebo on solar lentigines
Phytic acid · Journal of Cosmetic Dermatology, 2011Skin recovery by Lavandula angustifolia leaf callus extract: Redox control of Nrf2 signaling
Lavandula angustifolia oil lavender oil · Free Radical Biology & Medicine, 2025Assessment of the efficacy and safety of a new complex skin cream in Asian women: A controlled clinical trial
Hydroxyresveratrol · Journal of Cosmetic Dermatology, 2017Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence
Zinc oxide · Biomedicines, 2025Emulgels Containing Perilla frutescens Seed Oil, Moringa oleifera Seed Oil, and Mixed Seed Oil: Microemulsion and Safety Assessment
Moringa oleifera seed oil · Polymers, 2022Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters
Rosmarinus officinalis oil leaf rosemary oil leaf · Antioxidants, 2025Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage
Myristyl nicotinate · Experimental Dermatology, 2007Assessment of Cosmetic Properties and Safety of Use of Model Washing Gels with Reishi, Maitake and Lion's Mane Extracts
Grifola frondosa fruiting body extract · Molecules, 2022In vitro Percutaneous Absorption of Niacinamide and Phytosterols and in vivo Evaluation of their Effect on Skin Barrier Recovery
Phytosterols · Current Drug Delivery, 2016Starch- and carboxymethyl cellulose-based films as active beauty masks with papain incorporation
Carica papaya fruit extract · International Journal of Biological Macromolecules, 2023Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins
Grape seed oil · Skin Pharmacology and Physiology, 2007Clinical efficacy of herbal extract cream on the skin hydration, elasticity, thickness, and dermis density for aged skin: A randomized controlled double-blind study
Botanical extracts · Journal of Cosmetic Dermatology, 2019The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation
Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Panthenol, Panthenol vitamin b5, D-pantothenyl alcohol, Vitamin b5 panthenol, Vitamin b5, Panthenol b5 · Journal of Cosmetic Dermatology, 2025Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid, Hydrolyzed sodium hyaluronate · Aesthetic Plastic Surgery, 2026Towards a modern approach to traditional use of Helichrysum italicum in dermatological conditions: In vivo testing supercritical extract on artificially irritated skin
Helichrysum italicum extract, Helichrysum italicum oil flower · Journal of Ethnopharmacology, 2023New targets in the battle against dandruff
Epilobium angustifolium · Journal of Cosmetic Science, 2017Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin
Vitamin e · Journal of Cosmetic Dermatology, 2024Influence of lidocaine hydrochloride and penetration enhancers on the barrier function of human skin
Isopropyl myristate · International Journal of Pharmaceutics, 2014Development of levamlodipine long-acting patches based on an ion-pair strategy: Investigation of the mechanism for reducing skin irritation
Sorbic acid · International Journal of Pharmaceutics, 2024Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance
Hexylresorcinol · Archives of Dermatological Research, 2023Efficacy and Safety of a New Cosmeceutical Regimen Based on the Combination of Snail Secretion Filtrate and Snail Egg Extract to Improve Signs of Skin Aging
Snail secretion filtrate, Snail mucin · The Journal of Clinical and Aesthetic Dermatology, 2020Moisturizing potentials of ascorbyl palmitate and calcium ascorbate in various topical formulations
Ascorbyl palmitate · International Journal of Cosmetic Science, 2004Preparation and characterization of astaxanthin-loaded biodegradable polyhydroxybutyrate (PHB) microbeads for personal care and cosmetic applications
Astaxanthin powder, Astaxanthin · International Journal of Biological Macromolecules, 2024Standardized wild apple fruit extract as a bioactive agent in dermocosmetic products for efficacy skin hydration-In vitro and in vivo evaluation
Pyrus malus fruit extract · Journal of Cosmetic Dermatology, 2022Instrumental, clinical and subjective evaluation of the efficacy of a cosmetic treatment for home use
Acetyl glucosamine, N-acetyl glucosamine nag · Journal of Cosmetic and Laser Therapy, 2019Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer
Galactomyces ferment filtrate, Rice ferment filtrate, Saccharomyces ferment filtrate, Pitera, Sk-ii pitera concentrate · Journal of Clinical Medicine, 2022Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects
Sodium ascorbyl phosphate · Experimental Dermatology, 2012Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
Xylitol, Propanediol · Molecules, 2021Antioxidant and membrane-protective effects of the 3-O-ethyl ascorbic acid-cannabigerol system on UVB-irradiated human keratinocytes
3-o-ethyl ascorbic acid, Ethyl ascorbic acid, 2-o-ethyl ascorbic acid · Free Radical Biology & Medicine, 2025Enhancing the Cosmetic Potential of Aloe Vera Gel by Kombucha-Mediated Fermentation: Phytochemical Analysis and Evaluation of Antioxidant, Anti-Aging and Moisturizing Properties
Saccharomyces xylinum black tea ferment · Molecules, 2025Dually functionalized dendrimer for stimuli-responsive release of active ingredients into the skin
Palmitoyl pentapeptide-4 · Acta Biomaterialia, 2025Influence of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid on facial skin lipidome among seborrhea participants
Decylene glycol · Journal of Cosmetic Dermatology, 2022Efficacy and safety of a new peeling formulated with a pool of PHAs for the treatment of all skin types, even sensitive
Phas · Journal of Cosmetic Dermatology, 2023The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites
Retinyl palmitate, Retinyl palmitate vitamin a · Journal of Cosmetic Dermatology, 2013Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol
2-hexanediol, Caprylyl glycol · Cutaneous and Ocular Toxicology, 2009Salicin and Hederacoside C-Based Extracts and UV-Absorbers Co-Loaded into Bioactive Lipid Nanocarriers with Promoted Skin Antiaging and Hydrating Efficacy
Willow bark extract · Nanomaterials, 2022Topical Stabilized Super-Oxidized Hypochlorous Acid for Wound Healing in Hair Restoration Surgery: A Real-Time Usage-Controlled Trial Evaluating Safety, Efficacy, and Tolerability
Hypochlorous acid, Hypochlorous briohocl · Journal of Drugs in Dermatology, 2023Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects
Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024Active Components of Leontopodium alpinum Callus Culture Extract for Blue Light Damage in Human Foreskin Fibroblasts
Leontopodium alpinum meristem cell culture · Molecules, 2023Modulating effects of oatmeal extracts in the sodium lauryl sulfate skin irritancy model
Avena sativa kernel extract oat kernel extract · Skin Pharmacology and Applied Skin Physiology, 2002Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum
Diglycerin · Journal of Oleo Science, 2016A 10% Lactobionic acid-containing moisturizer reduces skin surface pH without irritation-An in vivo/in vitro study
Lactobionic acid · Journal of Cosmetic Dermatology, 2019Combining Topical and Oral Botanicals for Skin Redness, Pigmentation, Sleep, and Mood: A Randomized Controlled Study
Crocus sativus · Journal of Clinical Medicine, 2022Regenerative Skincare Technologies Derived From Human Fibroblasts: Growth Factors and Exosomes for Transformative Outcomes
Human fibroblast conditioned media · Dermatologic Surgery, 2024Effects of topical boswellic acid on photo and age-damaged skin: clinical, biophysical, and echographic evaluations in a double-blind, randomized, split-face study
Boswellia serrata extract · Planta Medica, 2010The Potential Role of Topically Applied Heparan Sulfate in the Treatment of Photodamage
Heparan sulfate · Journal of Drugs in Dermatology, 2015Enhancing transdermal delivery of retinyl acetate via transethosomes with emphasis on the impact of edge activators on penetration, safety, and efficacy
Retinyl acetate · Scientific Reports, 2025Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective
Tripeptide-1 · BioImpacts, 2025The tandem repeated irritation test: a new method to assess prevention of irritant combination damage to the skin
Toluene · Acta Dermato-venereologica, 2002Up-Cycling of Olea europaea L. Ancient Cultivars Side Products: Study of a Combined Cosmetic-Food Supplement Treatment Based on Leaves and Olive Mill Wastewater Extracts
Olea europaea olive leaf extract · Life, 2023Anti-Photoaging Effects of Upcycled Citrus junos Seed Anionic Peptides on Ultraviolet-Radiation-Induced Skin Aging in a Reconstructed Skin Model
Citrus junos fruit extract, Citrus junos extract · International Journal of Molecular Sciences, 2024Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging
Tetrahexyldecyl ascorbate, Ascorbyl tetraisopalmitate, Acetyl zingerone, Tetrahexyldecyl ascorbate vitamin c derivative, Vitamin c tetraisopalmitate · Journal of Cosmetic Dermatology, 2024Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients
3-o-ethyl ascorbic acid, Ethyl ascorbic acid, Ethyl ascorbic acid vc · International Journal of Biological Macromolecules, 2026Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy
Tocopheryl acetate, Tocopheryl acetate ve, Vitamin e tocopheryl acetate, Tocopheryl acetate vitamin e, Tocopheryl acetate vitamin e derivative · Scientific Reports, 2025Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
Caprylic capric triglyceride · Life, 2023Transdermal Delivery of Baicalin Based on Bio-Vesicles and Its Efficacy in Antiaging of the Skin
Scutellaria baicalensis root extract, Baicalin · Journal of Cosmetic Dermatology, 2025Functional properties and skin care effects of sodium trehalose sulfate
Trehalose · Skin Research and Technology, 2024Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris
Capryloyl salicylic acid, Hydroxyethylpiperazine ethane sulfonic acid, Hepes, Citric acid · Journal of Drugs in Dermatology, 2013Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence
Adenosine, Adenosine phosphate · International Journal of Molecular Sciences, 2026Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery
Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022Preliminary safety and in vivo efficacy of Acmella oleracea extract-loaded glycolipid emulsion serum-Effects on ocular irritation, dermal absorption, and facial skin biophysical and microrelief properties
Acmella oleracea extract, Spilanthol · International Journal of Cosmetic Science, 2025Improvement of urban eye skin in Chinese female by supramolecular retinol plus acmella oleracea extract-containing product
Acmella oleracea extract · Journal of Cosmetic Dermatology, 2022Histometric assessment of the age-related skin response to 2-hydroxy-5-octanoyl benzoic acid
Capryloyl salicylic acid · Skin Pharmacology and Applied Skin Physiology, 1998Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study
Hydrolyzed jojoba esters, Jojoba esters · Journal of Cosmetic Dermatology, 2008A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females
Ascorbyl glucoside, L-ascorbic acid 2-glucoside · Journal of Drugs in Dermatology, 2016Hippophae rhamnoides oil-in-water (O/W) emulsion improves barrier function in healthy human subjects
Hippophae rhamnoides fruit extract, Hippophae rhamnoides oil · Pakistan Journal of Pharmaceutical Sciences, 2014Treatment of Stretch Marks Using a New Formulation Combining Nanofractional Radiofrequency Plus Magnetic Nanofractional Radiofrequency
Beta-glucan · Dermatology and Therapy, 2023Evaluation of a retinol containing topical treatment to improve signs of neck aging
Glaucine · Journal of Cosmetic Dermatology, 2023Chitosan derivative nanocarrier: safety evaluation,antibacterial property and ascorbyl palmitate encapsulation
Ascorbyl palmitate · Journal of Microencapsulation, 2010Poly-γ-Glutamic Acid from a Novel Bacillus subtilis Strain: Strengthening the Skin Barrier and Improving Moisture Retention in Keratinocytes and a Reconstructed Skin Model
Polyglutamic acid · International Journal of Molecular Sciences, 2025Photoprotective, Antioxidant and Anti-Inflammatory Effects of Aged Punica granatum Extract: In Vitro and In Vivo Insights
Punica granatum extract · Food Science & Nutrition, 2025Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes
Artemisia princeps leaf extract · Molecular Medicine Reports, 2017The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study
3 essential ceramides · Journal of Cosmetic Dermatology, 2025Induction of extracellular matrix synthesis in normal human fibroblasts by anthraquinone isolated from Morinda citrifolia (Noni) fruit
Morinda citrifolia fruit extract · Journal of Medicinal Food, 2005Lemon Balm (Melissa officinalis L.) Leaf Extract Promotes Endo180 Production in Dermal Fibroblasts and has Antiwrinkle Effect on Human Skin
Melissa officinalis oil · Photodermatology, Photoimmunology & Photomedicine, 2025Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome
Lactobacillus ferment · Clinical, Cosmetic and Investigational Dermatology, 2023Macrocystis pyrifera ferment-containing creams for optimizing facial skin rejuvenation
Macrocystis pyrifera extract · Journal of Cosmetic Dermatology, 2023Taurine and Polyphenol Complex Repaired Epidermal Keratinocyte Wounds by Regulating IL8 and TIMP2 Expression
Chlorogenic acids · Current Issues in Molecular Biology, 2024Upcycled Cocoa Pod Husk: A Sustainable Source of Phenol and Polyphenol Ingredients for Skin Hydration, Whitening, and Anti-Aging
Theobroma cacao seed extract · Life, 2025Study of the soothing effects of troxerutin in alleviating skin sensitivity
Troxerutin · Journal of Cosmetic Dermatology, 2024Protective properties of Avène Thermal Spring Water on biomechanical, ultrastructural and clinical parameters of human skin
La roche-posay thermal spring water, Thermal spring water · Journal of the European Academy of Dermatology and Venereology, 2020Sustained effect of two antioxidants (oxothiazolidine and δ-tocopheryl glucoside) for immediate and long-term sun protection in a sunscreen emulsion based on their different penetrating properties
Tocopheryl glucoside · International Journal of Cosmetic Science, 2021Potential of electro-sprayed purified mangiferin nanoparticles for anti-aging cosmetic applications
Mangifera indica leaf extract · RSC Advances, 2023Arnica montana L. extract containing 6-O-methacryloylhelenalin and 6-O-isobutyrylhelenalin accelerates growth and differentiation of human subcutaneous preadipocytes and leads volumizing of skin
Arnica montana extract · International Journal of Cosmetic Science, 2023Cyano-phycocyanin loaded enriched transfersomes for enhanced topical skin delivery and antioxidant protection
Spirulina platensis extract · International Journal of Pharmaceutics, 2025A Prospective, Randomized, Double-Blind, Split-Face Trial Evaluating the Effects of Pre-Conditioning With a TriHex Technology Serum Nectar 2.0 Versus a Vehicle in Subjects Undergoing Elective Facelift Surgery
Trihex technology · Journal of Cosmetic Dermatology, 2025Ethanolamines permeate slowly across human skin ex vivo, but cause severe skin irritation at low concentrations
Ethanolamine · Archives of Toxicology, 2019Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits
Palmitoyl hexapeptide-12 · ACS Applied Bio Materials, 2025Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate, Tocopheryl acetate vitamin e, Tocopheryl acetate ve, Vitamin e tocopheryl acetate, Tocopheryl acetate vitamin e derivative · Contemporary Clinical Trials Communications, 2021Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora
Pdrn polydeoxyribonucleotide, Sodium dna · International Journal of Molecular Sciences, 2025Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy
Pdrn polydeoxyribonucleotide · International Journal of Biological Macromolecules, 2025Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos
Activated c, Ascorbyl glucoside, L-ascorbic acid 2-glucoside · International Journal of Molecular Sciences, 2024Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging
Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study
Zinc gluconate · Journal of Cosmetic Dermatology, 2026Investigating the Effects of a Manuka Honey, Royal Jelly, and Bee Venom-Derived Face Serum on Skin Health and Signs of Aging
Manuka honey, Royal jelly · Cureus, 2025Clinical and histologic findings after use of a novel combined retinol, tripeptide, and glaucine containing cream in the treatment of photo-aged skin
Glaucine · Journal of Cosmetic Dermatology, 2023The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study
Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing
Retinyl propionate, Hexylresorcinol, Pro-retinol · International Journal of Cosmetic Science, 2024Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation
Retinyl propionate · International Journal of Cosmetic Science, 2017Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A randomized placebo-controlled study
Snail secretion filtrate, Snail mucin · Journal of Cosmetic Dermatology, 2022A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties
Phyto-retinol, Bakuchiol, Soy isoflavones · Skin Research and Technology, 2026Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months-An 11-Year Longitudinal Skin Aging Rejuvenation Study
Galactomyces ferment filtrate, Saccharomyces ferment filtrate, Pitera · Journal of Clinical Medicine, 2023Pleiotropic effects of a Camellia sinensis leaf extract on in vitro and in vivo skin health characteristics
Camellia sinensis leaf water, Black tea extract · International Journal of Cosmetic Science, 2025Significant improvement in crow's feet after treatment with Jet-M and a mixed solution of copper-GHK, oligo-hyaluronic acid, rhodiolar extract, tranexamic acid, and β-glucan (GHR formulation)
Tripeptide-1 · Journal of Cosmetic and Laser Therapy, 2016Facial disbiosis and UV filters
Octinoxate · Archives of Dermatological Research, 2024Artemisia capillaris with two novel active compounds, Kawarayomogin I and II, inhibits HYBID (KIAA1199) expression as well as hyaluronic acid degradation
Artemisia capillaris flower extract · Scientific Reports, 2025Preliminary evaluation of a comprehensive skincare regimen for enhancing skin health following advanced optimal pulse technology (AOPT) treatment
Ergothioneine · International Journal of Cosmetic Science, 2025Microneedling and Topical Retinyl Palmitate for Acne Scars: A Preliminary Split-Face Study with Placebo Control
Retinyl palmitate · Journal of Clinical Medicine, 2026Isosorbide Diesters: Mechanistic Insights and Therapeutic Applications in Skin and Neuroinflammatory Disorders
Isosorbide dicaprylate · International Journal of Molecular Sciences, 2025A bioactive complex to protect proteins from UV-induced oxidation in human epidermis
Ethyl linoleate, Panthenyl triacetate · International Journal of Cosmetic Science, 2010Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs
Ethyl linoleate · JID Innovations, 2023Effects of Malaysian thermal spring water as adjunct therapy for mild to moderate acne vulgaris - a prospective, randomised, controlled, split face study
Avène thermal spring water, La roche-posay thermal spring water, Avene thermal spring water avene aqua, Thermal spring water · The Medical Journal of Malaysia, 2024Open-label topical application of tetrahexyldecyl ascorbate and acetyl zingerone containing serum improves the appearance of photoaging and uneven pigmentation
Acetyl zingerone, Tetrahexyldecyl ascorbate vitamin c derivative · Journal of Cosmetic Dermatology, 2024Evaluation of tolerability and skin changes after application of topical antiaging products based on Sibanid SG®, plant stem cells and regenerative and biostimulating active ingredients
Plant cells stem · Giornale Italiano Di Dermatologia E Venereologia, 2019A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen
Pha polyhydroxy acid · Cutis, 2004Skin moisturization by hydrogenated polyisobutene--quantitative and visual evaluation
Volufiline, Polyisobutylene · Journal of Cosmetic Science, 2009Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling
Lactobacillus portulaca oleracea extract ferment, Portulaca oleracea extract, Portulaca oleracea extract purslane extract · Cutaneous and Ocular Toxicology, 2022Real-world experience with a treatment with a skincare regimen of products containing the Macrocystis pyrifera ferment for optimizing facial skin rejuvenation
Macrocystis pyrifera extract · Journal of Cosmetic Dermatology, 2024Enhanced Whitening Effect of the Formulations via Inhibition of Tyrosinase Activity by Combination of 4-n-Butylresorcinol, Licochalcone A and Glabridin at an Optimal Ratio
Glycyrrhiza glabra root extract · Skin Research and Technology, 2026Activity of Angelica sinensis extract for cutaneous applications: antioxidant, anti-senescent, and antimicrobial effects
Angelica acutiloba root extract · Frontiers in Pharmacology, 2026Potassium 4-Methoxysalicylate (4MSK) Exerts a Skin Lightening Effect by Acting on Melanocytes and Keratinocytes
Potassium methoxysalicylate · Journal of Cosmetic Dermatology, 2025Effects of fermented tea seed oil on the skin lipid barrier and microbiome of sensitive skin
Camellia sinensis seed oil · International Journal of Cosmetic Science, 2026Clinical efficacy of biocellulose, carboxymethyl cellulose and normal saline dressing in epidermolysis bullosa
Cellulose gum · Journal of Wound Care, 2019Evaluation of vulvar irritancy potential of a menstrual pad containing sodium bicarbonate in short-term application
Sodium bicarbonate · The Journal of Reproductive Medicine, 1991Evolution of lipid composition in skin treated with blackcurrant seed oil
Ribes nigrum seed oil · International Journal of Cosmetic Science, 1988Exploring the microbiota-skin-brain axis: Chicory extract biotransformed into a postbiotic neurocosmetic enhancer of social and sensory experience
Cichorium intybus leaf extract · International Journal of Cosmetic Science, 2026Evaluation of the effectiveness of Berberis integerrima Bunge root extract combined with spearmint essential oil in the treatment of acne vulgaris: A randomized controlled clinical trial
Spearmint extract · Journal of Cosmetic Dermatology, 2024Human Stem Cell-Derived Skin Progenitors Produce Alpha 2-HS Glycoprotein (Fetuin): A Revolutionary Cosmetic Ingredient
Glycoproteins · Journal of Drugs in Dermatology, 2016Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking
Matrixyl 3000, Palmitoyl tripeptide-1 acetate, Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1 · International Journal of Cosmetic Science, 2026Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial
Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism
Palmitoyl tripeptide-1 acetate, Palmitoyl tripeptide-1, Palmitoyl oligopeptide, Baicalin, Tripeptide-1 · Journal of Cosmetic Dermatology, 2026Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters
Gluconolactone · Skin Research and Technology, 2023Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population
Bakuchiol, Phyto-retinol · Health Science Reports, 2025Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial
Ascorbyl glucoside · Cureus, 2026Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial
Argan oil, Butyrospermum parkii butter shea butter, Saccharide isomerate, Shea butter · Lasers in Medical Science, 2025Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis
Palmitoyl pentapeptide-4 · Cureus, 2026Efficacy of anti-sebum moisturizing cream containing 2% l-carnitine and 5% epigallocatechin gallate in seborrhea: A randomized clinical trial
Camellia sinensis leaf water · Journal of Cosmetic Dermatology, 2023Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu
Copper tripeptide-1, Tripeptide-1 · Skin Research and Technology, 2026Evaluation of Saponin-Rich Callus from Saponaria officinalis L. as a Novel Scrub Material with Significant Exfoliating and Anti-Inflammatory Effects
Saponins · Plants, 2025Novel Glyceryl Ascorbate Derivatives Inhibit Type 2 Alarmin Cytokine Induction and Promote Expression of Epidermal Barrier Function-Related Factors in Human Keratinocytes in vitro
Bis-glyceryl ascorbate · Skin Pharmacology and Physiology, 2026Simmondsia chinensis (jojoba) cake fermentation: A new, sustainable technology for advanced skin and scalp care ingredients
Lactobacillus ferment · International Journal of Cosmetic Science, 2026A Multicenter Trial of an Enhanced Serum Comprised of 13 Plant-Based Adaptogens Targeting Skin Quality in Females Impacted by Hormonal Decline
Adaptogens · Journal of Cosmetic Dermatology, 2026A Randomized, Double-blind, Split-face Trial Evaluating the Safety and Efficacy of a Serum Containing Plant Adaptogens Versus Moisturizing Lotion Pre- and Post-fractional Laser in Patients with Mild-to-moderate Photodamage
Adaptogens · The Journal of Clinical and Aesthetic Dermatology, 2026Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis
Ergothioneine · Frontiers in Nutrition, 2026Acai Oil-Based Organogel Containing Hyaluronic Acid for Topical Cosmetic: In Vitro and Ex Vivo Assessment
Euterpe oleracea fruit extract · Pharmaceutics, 2024Periprocedural Use of Hypochlorous Acid Mist for Improving Healing and Cosmesis of the Face After Laser
Hypochlorous acid · Journal of Cosmetic Dermatology, 2025Toxicological Safety, Antimicrobial Efficacy, and Sensory Evaluation of River Sand-Derived Mica From Bangladesh: A Comprehensive Assessment for Cosmetic Applications
Mica · Journal of Cosmetic Dermatology, 2025The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies
Dipeptide diaminobutyroyl benzylamide diacetate, Laminaria digitata extract · International Journal of Cosmetic Science, 2026The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color
Galactomyces ferment filtrate, Saccharomyces ferment filtrate, Sk-ii pitera concentrate · Skinmed, 2021Dual-function supramolecular system of α-hydroxy acid-based ionic liquids and peptides for enhanced anti-aging transdermal delivery
Malic acid · Journal of Materials Chemistry. B, 2025Structure/property comparisons of chemistries based on renewable 1,3-propanediol and petroleum-derived alkylene oxides
Propanediol · Journal of Cosmetic Science, 2017Microcirculation-Promoting Effect of Escin on Cutaneous Tissue via Gsk3β Down-Regulation
Escin · Current Issues in Molecular Biology, 2025Microcirculatory efficacy of topical treatment with aescin + essential phospholipids gel in venous insufficiency and hypertension: new clinical observations
Escin · Angiology, 2004Salicylic acid peel incorporating triethyl citrate and ethyl linoleate in the treatment of moderate acne: a new therapeutic approach
Ethyl linoleate · Dermatologic Surgery, 2013A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study
Saccharide isomerate · The Journal of Dermatological Treatment, 2025Saccharide isomerate ameliorates cosmetic scalp conditions in a Chinese study population
Saccharide isomerate · Journal of Cosmetic Dermatology, 2023Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin
Lactobacillus portulaca oleracea extract ferment, Portulaca oleracea extract, Portulaca oleracea extract purslane extract · Cutaneous and Ocular Toxicology, 2025A Topical Formulation Containing Macrocystis Pyrifera Ferment for Managing Barrier Damage After Mild-Moderate Skin Disruption from Cosmetic Dermatologic Procedures
Macrocystis pyrifera extract · The Journal of Clinical and Aesthetic Dermatology, 2025Comparative Efficacy of Topical N-Acetylcysteine-Doxycycline versus Benzoyl Peroxide-Doxycycline in Moderate Acne Vulgaris: An Add-on Double-Blind Randomized Controlled Trial
Acetyl cysteine · Dermatology Practical & Conceptual, 2026A New Cosmeceutical Approach for Mature Skin: Antioxidant Activity, In Vitro Permeation, and Preliminary Clinical Efficacy of Melatonin-N-Acetylcysteine Creams
Acetyl cysteine · Antioxidants, 2026Development, Stability, and Clinical Efficacy of an Oil-in-Serum Formulation with Olive Extract Standardized in Hydroxytyrosol for Post-Inflammatory Hyperpigmentation Treatment
Hydroxytyrosol · AAPS PharmSciTech, 2026Hydroxyethyl cellulose as carbohydrate polymer scaffold for surfactant-free serums with enhanced hydration and structural stability
Hydroxyethylcellulose · International Journal of Biological Macromolecules, 2026Development, characterization, and clinical investigation of Spinacia oleracea-based ultra-high pressure homogenized emulsion system for facial physiological parameters
Spinach leaf extract · Journal of Cosmetic Dermatology, 2022Cornus officinalis Fruit Extract as an AMPK-Associated Mitochondrial Bioenergetic Modulator in Skin Aging Models
Cornus officinalis fruit extract · Biomedicines, 2026Protection from combination exposure
Toluene · Current Problems in Dermatology, 2007Protective Effects of an Advanced Antioxidant Serum and an Encapsulated Vitamin C Serum From UV-Induced Erythema and Oxidative Stress
Vitamin capsule · The Journal of Clinical and Aesthetic Dermatology, 2026Treatment of molluscum contagiosum with an East Indian sandalwood oil product
Sandalwood oil wood · The Journal of Dermatological Treatment, 2018Preclinical Safety Evaluation of Dual Drug-Loaded Nanolipidic Carriers of Dissolvable Patches: In-Vitro and In-Vivo Safety Assessment
Tetrahydrodiferuloylmethane · Molecular Pharmaceutics, 2025A highly soluble form of rutin for instant resolution of mask-wearing related disorders
Glucosylrutin · Journal of Cosmetic Dermatology, 2024