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Avène vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Avène and Sesderma are trusted European skincare houses founded in 1990 and 1989, respectively, offering distinct formulations tailored to varied complexions. The French brand relies on science-backed formulations featuring hydrating glycerin, rich moisturizers, reliable sunscreens, targeted serums, and gentle cleansers that suit oily acne-prone skin and acne-prone skin best through products like the Tolerance Control Soothing Skin Recovery Balm, the Cleanance, and the Hyaluron Activ B3 Concentrated Plumping Serum. Meanwhile, the Spanish brand is beloved for advanced serums and meticulously engineered formulas utilizing botanical extracts and active compounds—such as the Azelac RU Serum—that suit sensitive, hyperpigmented, and aging skin types best. While both achieve a calm and radiant complexion, they differ as the former focuses on barrier restoration and the latter promotes refined texture.

Avène is a French skincare brand founded in 1990 and owned by Fondation Pierre Fabre.

pierre-fabre.comavene.co.ukaveneusa.com

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Avène and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Avène vs Sesderma products

Questions and answers

Avène or Sesderma: which is better?

Avène provides a much broader selection of products on this page across diverse skin types and concerns, whereas Sesderma is represented by a single serum focused on acne-prone skin and dark spots. Avène is often noted by reviewers for soothing irritation and offering gentle cleansers and sunscreens, though some products contain fragrance.

What is the difference between Avène and Sesderma?

Avene offers an extensive range of products on this page tailored to various skin types, featuring key ingredients like glycerin and thermal water supported by studies on skin hydration. In contrast, Sesderma is represented on this page by just one product, Azelac RU Serum, which contains azelaic acid that helps with acne-prone skin and dark spots.

Pharmaceutics, 2021

Which is more affordable, Avène or Sesderma?

Reviewers note that the price point of the products on this page is sometimes an issue for Avene, whereas information regarding affordability is not available for Sesderma.

Which causes fewer breakouts, Avène or Sesderma?

Avène provides a wide range of products on this page for acne-prone skin, such as Cleanance Cleansing Gel which has a High fit level for oily acne-prone skin, whereas Sesderma features only Azelac RU Serum.

When was Avène founded compared to Sesderma, and in which countries?

Avène was founded in 1990 in France, while Sesderma was founded a year earlier in 1989 in Spain.

How many products from Avène are fragrance-free according to the page?

According to the page, 8 of the 15 Avène products list no fragrance.

Which skin types does the Azelac RU Serum by Sesderma fit best?

Lovi finds that Azelac RU Serum by Sesderma has a High fit for acne-prone skin, skin with dark spots, and combination skin.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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