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Clinique vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Clinique and Sesderma are distinguished skincare brands that offer thoughtful solutions for diverse complexions. The American brand is widely loved for its moisturizers, serums, makeup removers, and eye products featuring hyaluronic acid, glycerin, and caffeine, making it best suited for dry sensitive and oily skin. Conversely, the Spanish brand is beloved for its advanced serums and meticulously engineered formulas that best suit sensitive, hyperpigmented, and aging skin. While both emphasize targeted care, they differ in their foundational ingredients and regional heritage.

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

en.wikipedia.orgelcompanies.combusinesswire.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Clinique and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Clinique vs Sesderma products

Questions and answers

Clinique or Sesderma: which is better?

Clinique is generally a better choice on this page for most users, as it offers a wide range of fragrance-free products with High Lovi fit levels for dry sensitive, oily, and mature skin. Sesderma features only one product on the page, the Azelac RU Serum, which contains fragrance and is less suited for dry skin.

What is the difference between Clinique and Sesderma?

Clinique features a large range of fragrance-free products on this page with High fit levels for dry sensitive, oily, and mature skin, while Sesderma is represented by a single serum that contains fragrance and achieves High fit levels for acne-prone skin and skin with dark spots.

Which is more affordable, Clinique or Sesderma?

The provided page facts do not contain pricing information to determine whether Clinique or Sesderma is more affordable.

Which causes fewer breakouts, Clinique or Sesderma?

Clinique is unlikely to cause breakouts for the products on this page, as reviewers sometimes note breakouts, whereas Sesderma lacks sufficient reviewer data for comparison.

How do the founding years and countries of origin compare between Clinique and Sesderma?

Clinique was founded in the United States in 1968, whereas Sesderma was founded in Spain in 1989.

Which brand offers a greater variety of products for different skin types on this page, Clinique or Sesderma?

Clinique offers a greater variety of products for different skin types on this page, featuring multiple items for dry sensitive skin, oily skin, and mature skin, whereas Sesderma is represented by only one product.

Do both Clinique and Sesderma offer fragrance-free products according to the ingredient lists?

Clinique offers fragrance-free products since every product on this page lists no fragrance in its ingredients, whereas Sesderma includes fragrance in its Azelac RU Serum.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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