Sesderma Azelac RU Liposomal Serum for skin with dark spots
Azelaic Acid
Tranexamic Acid
Retinol
Niacin
4-ButylresorcinolAverage
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for skin with dark spots; other serums fit it better.
This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate brightening and evening of skin tone for your normal skin due to the presence of tranexamic acid and 4-butylresorcinol, which regulate melanogenesis. Retinol also provides good antioxidant activity, supporting overall skin health.
- While the product offers general hydration and soothing benefits, these are largely supportive and not directly targeted at your main goal of pigmentation.
- The product is safe for your normal skin, as it lacks prohibited or harsh ingredients and has no risk of irritation.
How to apply
- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
People Say
★4.2Overall rating based on 100+ reviewsBased on limited data, users frequently report this serum effectively brightens the complexion and reduces hyperpigmentation like melasma, sun spots, and acne marks, leading to smoother and more luminous skin. Many appreciate its fast absorption and lightweight feel. Some users with sensitive or dry skin find it can be drying and recommend using a moisturizer.
Highlights
Fast absorption Mostly Mentioned
- “absorbing very fast”
- “lightweight”
- “no oily residue”
- “sinks deep into skin”
Fades dark spots Often Mentioned
- “huge difference in pigmentation”
- “removed stains from face”
- “fades spots fast”
- “marks down to faint shadows”
Improves texture Often Mentioned
- “skin smooth and luminous”
- “leaves skin glowy”
- “soft and alive”
- “texture is better”
Acne control Sometimes Noted
- “kept breakouts at bay”
- “pimples heal faster”
- “good for acne”
- “prevented new imperfections”
Drying effect Sometimes Noted
- “cheeks felt tight”
- “can dry you out”
- “needs moisturizer”
- “slightly aggressive initially”
High price Rarely Noted
- “expensive”
- “small bottle”
- “pricey for the size”
Slow results Rarely Noted
- “didn't see any effect”
- “oldest marks still there”
- “not a magic wand”
- “took forever to work”
Sticky finish Rarely Noted
- “sticky at first”
- “slight tacky feel”
- “feels a bit sticky”
Sources: lovi.care, notino.ie, influenster.com, skinsort.com, perfumesclub.co.uk, makeup.uk, and more
Questions and answers
How well does Sesderma Azelac RU Liposomal Serum work for skin with dark spots?
This serum works moderately well for skin with dark spots, offering some brightening and evening of skin tone with ingredients like tranexamic acid and 4-butylresorcinol. To work best for dark spots, a product of this type needs a blend of effective antioxidants and soothing ingredients that provide significant benefits for pigmentation concerns without any risk of irritation.
Which ingredients make this serum a good fit for skin with dark spots?
Tranexamic acid and 4-butylresorcinol make this serum a good fit for skin with dark spots because they help regulate pigment production to brighten and even out skin tone. For this skin, a treatment of this type needs strong antioxidants, soothing ingredients, and niacinamide to effectively target dark spots without causing irritation.
What does Azelaic Acid do for skin with dark spots?
Azelaic acid helps fade dark spots and uneven skin tone by slowing down the overactive pigment production in your skin cells. It is unlikely to cause irritation and may gradually clear up stubborn marks left behind by breakouts or sun exposure.
Dermatology and Therapy, 2024Archives of Dermatological Research, 1990
What does Tranexamic Acid do for skin with dark spots?
Tranexamic acid helps fade dark spots and uneven patches by slowing down the signals that trigger excess pigment in the skin. Studies show that using it regularly can significantly improve skin tone with a low risk of side effects.
Clinical and Experimental Dermatology, 2016Journal of Drugs in Dermatology, 2019
Where does this serum go in a skincare routine for skin with dark spots?
This serum goes in the evening routine after cleansing and toning, and before moisturizing. Skin with dark spots typically benefits most from a dedicated treatment product packed with targeted brightening ingredients like concentrated vitamin C, kojic acid, or alpha arbutin.
Can I use this serum with vitamin C, and in what order?
You can use this serum with vitamin C by applying vitamin C in the morning and this treatment at night to avoid overwhelming your skin. This product of this type needs powerful brightening ingredients like tranexamic acid, azelaic acid, and 4-butylresorcinol to fade dark spots effectively.
How often should I use this serum?
Use this serum in your evening routine, starting gradually once a week as part of an exfoliating routine and increasing frequency only if your skin tolerates it well. This helps you safely introduce active ingredients like retinol and azelaic acid while avoiding potential irritation.
Can this serum clog pores, cause breakouts or purging for skin with dark spots?
This serum is unlikely to cause breakouts or clog pores on skin with dark spots because it is safe and free of harsh ingredients. Products for this skin need targeted brightening ingredients like azelaic acid and tranexamic acid, alongside gentle hydrators to keep the face clear and smooth.
Is this serum fragrance-free and alcohol-free?
It contains fragrance (parfum) and drying alcohol (alcohol and alcohol denat).
What the research says
Topical myristyl nicotinate increased skin cell NAD, stratum corneum thickness, epidermal thickness, epidermal renewal, minimal erythemal dose, and barrier resistance while reducing transepidermal water loss in subjects with photodamaged skin compared to placebo.
Experimental Dermatology, 2007Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne.
Pharmaceutics, 2021Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo.
Dermatology and Therapy, 2024Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks.
Journal of the European Academy of Dermatology and Venereology, 2023Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.
International Journal of Cosmetic Science, 2017Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.
Journal of Controlled Release, 2018Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks.
Journal of Cosmetic Dermatology, 20164-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks.
Journal of the European Academy of Dermatology and Venereology, 2013Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications.
Molecular Pharmaceutics, 2017
Ingredients
Water, Lecithin, Propanediol, Alcohol, Bellis Perennis Flower Extract, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, Propylene Glycol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-Butylresorcinol, Alcohol Denat, Ascorbyl Glucoside, Azelaic Acid, Bha, Bht, Caprylic Capric Triglyceride, Carbomer, Citronellyl Methylcrotonate, Grapefruit Fruit Extract, Diacetyl Boldine, Dipotassium Phosphate, Disodium Edta, Disodium Phosphate, Ethylhexylglycerin, Glycerin, Glycyrrhetinic Acid, Hydrochloric Acid, Hydroxypropyl Cyclodextrin, Melissa Officinalis Leaf Extract, Morus Alba Root Extract, Niacin, Nicotiana Benthamiana Sh-Polypeptide-7, Parfum, Peg Ppg-20 6 Dimethicone, Phenethyl Alcohol, Phenoxyethanol, Polysorbate 20, Potassium Phosphate, Potassium Sorbate, Retinal, Retinol, Sodium Chloride, Sodium Cholate, Sodium Hydroxide, Tocopheryl Acetate, Tranexamic Acid, Triethanolamine, Triisopropanolamine, Undecylenoyl Phenylalanine, Xanthan Gum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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