Shiseido Eudermine Revitalizing Essence for skin with dark spots

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Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Regular application of cosmetic submicron emulsions and gels containing hydroxypropyl-beta-cyclodextrin showed no statistically significant effects on skin barrier function and observed physiological skin parameters in 15 healthy human subjects over four weeks, indicating good skin tolerability.

  International Journal of Cosmetic Science, 2021

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Topical retinoic acid-beta-cyclodextrin complex formulations at 0.025% showed greater acne improvement scores (4.0-4.1) and lower irritation than a commercial 0.05% retinoic acid gel (score 3, with side effects in all patients) after 3 months in 66 patients with acne vulgaris.

  Journal of the European Academy of Dermatology and Venereology, 2004

• Tretinoin cyclodextrin complex demonstrated an antiwrinkle effect equal to that of conventional tretinoin with more moderate irritant reactions in photoaged patients.

  Aesthetic Plastic Surgery, 2012

• Binary systems of trans-resveratrol with polyethylene glycol or beta-cyclodextrin enhanced its antioxidant activity and in vivo skin anti-aging effects compared to trans-resveratrol alone in human keratinocytes and volunteers.

  Drug Development and Industrial Pharmacy, 2014

Ingredients

Water, Butylene Glycol, Alcohol Denat, Glycerin, Methyl Gluceth-10, Dipropylene Glycol, Betaine, Methylparaben, Cyclodextrin, Phenoxyethanol, Sodium Metaphosphate, Sodium Hyaluronate, Carbomer, Parfum, Peg-60 Hydrogenated Castor Oil, Xanthan Gum, Potassium Hydroxide, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Arginine Hcl, Magnesium Chloride, Pca, Calcium Chloride

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.