iS Clinical Active Serum for combination skin
Saccharum Officinarum Extract
Vaccinium Myrtillus Extract
Arbutin
Willow Bark Extract
Polyporus Umbellatus Extract Mushroom Extract
High
- SuperiorCombination Skin Fit
- HighEffectiveness
- HighSafety
A great choice for combination skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers excellent treatment for your acne lesions and blemishes due to willow bark extract and saccharum officinarum extract, which aid in exfoliating and decongesting pores, making it highly suitable for your combination skin.
- The formula provides moderate exfoliation for oily shine with saccharum officinarum extract and vaccinium myrtillus leaf extract, while alcohol denat offers mild keratolytic action.
- This product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★4.6Overall rating based on 1000+ reviewsUsers consistently praise this serum as a "holy grail" multitasker that effectively targets adult acne while simultaneously smoothing fine lines and uneven texture. While the potent "tingling" sensation confirms its activity for most, the high price point and potential for dryness are common considerations for new users.
Highlights
Clears Acne & Breakouts Mostly Mentioned
- “breakouts have been less severe and fewer”
- “helps prevent breakouts”
- “cystic acne is gone”
- “eradicate blackheads”
Improves Texture & Tone Often Mentioned
- “skin feels softer”
- “smooths skin texture”
- “pores look smaller”
- “glows after 2 days”
High Price Point Often Mentioned
- “expensive for small bottle”
- “wish it was cheaper”
- “investment product”
- “pricey but worth it”
Anti-Aging Benefits Sometimes Noted
- “softens fine lines”
- “boosts collagen production”
- “skin looks younger”
- “diminished wrinkles”
Fast Visible Results Sometimes Noted
- “results within a couple of days”
- “woke up and skin looked rested”
- “immediate results”
- “overnight difference”
Intense Tingling Sensation Sometimes Noted
- “burns a little”
- “strong tingle at first”
- “stings upon application”
- “sensation was too much”
Drying for Some Rarely Noted
- “can be drying”
- “need a good moisturizer after”
- “skin felt tight”
- “flaking around nose”
Risk of Counterfeits Rarely Noted
- “received fake product”
- “color was yellow not clear”
- “smelled different than usual”
- “bottle looked off”
Sources: lovi.care, lovelyskin.com, dermstore.com, walmart.com, brainsstreet.com.au, and more
Questions and answers
What makes iS Clinical Active Serum a great fit for combination skin?
iS Clinical Active Serum is a great fit for your combination skin because willow bark extract and saccharum officinarum extract exfoliate and clear out congested pores to treat breakouts. The formula also helps balance oily shine with moderate exfoliation while keeping your skin safe from irritation.
Journal of Cosmetic Dermatology, 2019Clinical, Cosmetic and Investigational Dermatology, 2019
Which ingredients make this serum a good fit for combination skin?
Willow bark extract and saccharum officinarum extract make this serum a great fit because they help exfoliate and clear out clogged pores. Vaccinium myrtillus leaf extract and alcohol denat also help manage oily shine, while the formula's safe ingredients are unlikely to cause irritation.
Journal of Cosmetic Dermatology, 2019Clinical, Cosmetic and Investigational Dermatology, 2019
What does Sugarcane Extract do for combination skin?
Sugarcane extract is a source of glycolic acid that helps sweep away dead skin cells to keep combination skin smooth and balanced. It helps clear clogged pores and may improve skin texture without causing excessive dryness in drier areas.
What does Bilberry Fruit Extract do for combination skin?
Bilberry Fruit Extract helps keep combination skin smooth, soft, and even in tone while protecting it from everyday damage. It works well because its antioxidants help calm stressed areas and improve overall skin texture without feeling heavy.
Where does this serum go in a skincare routine for combination skin?
This treatment goes in the evening routine after cleansing toners and before your moisturizer. Lovi routines place treatments at night for simplicity and extra safety around sun exposure, though some can also be used in the morning or twice a day.
Can I use this serum with retinol, and in what order?
You can use this treatment in your evening routine, but use retinol on alternate nights to avoid irritation. Applying both together may be too strong for your skin and lead to dryness or redness.
How often should I use this serum?
Use this serum once a week in the evening to start, and if your skin handles it well and sees good results, you can carefully use it more often. This product is safe for your combination skin and helps clear up breakouts and oily shine.
Journal of Cosmetic Dermatology, 2019Clinical, Cosmetic and Investigational Dermatology, 2019
Can this serum clog pores, cause breakouts or purging for combination skin?
This serum is unlikely to clog pores or cause breakouts because it helps clear out and decongest pores with willow bark extract and saccharum officinarum extract. It is safe for combination skin and has no harsh ingredients that typically cause irritation or new breakouts.
Journal of Cosmetic Dermatology, 2019Clinical, Cosmetic and Investigational Dermatology, 2019
Is this serum fragrance-free and alcohol-free?
It has no fragrance and contains drying alcohol (alcohol denat).
What the research says
Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks.
International Journal of Dermatology, 2000Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days.
Nutrients, 2024Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers.
Antioxidants, 2021Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations.
Antioxidants, 2024A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability.
Journal of Cosmetic Science, 2020Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations.
Heliyon, 2023Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants.
Journal of Cosmetic Dermatology, 2025A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation.
Journal of Cosmetic Dermatology, 2019Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil.
Nanomaterials, 2022A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline.
Journal of Cosmetic Dermatology, 2010White button mushroom extract treatment increased VEGF densities, EGF, PCNA, and collagen fibers, while decreasing apoptotic cells and limiting TGF-beta and CD4 reactions in ICR mice and chorioallantoic culture, indicating beneficial effects on skin regeneration and injury.
Microscopy Research and Technique, 2012
Ingredients
Water, Glycerin, Butylene Glycol, Alcohol Denat, Saccharum Officinarum Extract, Vaccinium Myrtillus Leaf Extract Fruit, Triethanolamine, Willow Bark Extract, Glyceryl Polyacrylate, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Menthol, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
-
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
-
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
-
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
-
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
-
Medical Board
Cosmetic chemist, SCS, IFSCC member
-
Medical Board, Medical Advisor
Dermatology MD
-
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
-
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.