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CeraVe vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

CeraVe and Sesderma are trusted skincare brands that offer reliable daily routines and advanced treatments, respectively. The American brand, founded in 2005, is known for dependable moisturizers, gentle cleansers, targeted serums, and protective sunscreens enriched with hyaluronic acid and glycerin, suiting mature and dry skin best. Meanwhile, the Spanish brand, founded in 1989, is beloved for advanced serums and meticulously engineered formulas that suit sensitive, hyperpigmented, and aging skin. While both deliver proven results through active compounds and botanical extracts, the former relies on barrier-supporting ingredients like glycerin, whereas the latter specializes in synergistic treatments like the Azelac RU Serum.

CeraVe is an American skincare brand founded in 2005 and owned by L'Oréal since 2017.

en.wikipedia.orghappi.comloreal-finance.comcerave.com

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular CeraVe and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular CeraVe vs Sesderma products

CeraVe vs Sesderma serums and treatments

Questions and answers

CeraVe or Sesderma: which is better?

CeraVe has a Superior fit for mature and dry skin, whereas the products on this page for Sesderma do not focus on those skin types.

What is the difference between CeraVe and Sesderma?

CeraVe offers a broad range of fragrance-free products on this page with High to Superior Lovi fit levels for dry, mature, and acne-prone skin, while Sesderma features only a single serum containing fragrance. CeraVe relies on key ingredients like ceramides and hyaluronic acid, which help repair the skin barrier and provide deep hydration.

Journal of Pharmacy & Pharmaceutical Sciences, 2015

Which is more affordable, CeraVe or Sesderma?

The page facts do not provide pricing information for either CeraVe or Sesderma, so it is not possible to determine which brand is more affordable.

Which causes fewer breakouts, CeraVe or Sesderma?

CeraVe features many products on this page with a Superior or High fit for acne-prone skin and reviewers note that its cleansers are effective for acne, while Sesderma has a more limited selection. However, the products on this page sometimes note that CeraVe may cause breakouts.

How do the founding years and countries of origin compare between CeraVe and Sesderma?

CeraVe was founded in the United States in 2005, whereas Sesderma was founded in Spain in 1989.

Which brand offers a greater number of products listed on the page, and how do their fragrance-free options compare?

CeraVe offers a greater number of products listed on the page compared to Sesderma. Furthermore, every product on the CeraVe page lists no fragrance in its ingredients, whereas only zero out of one product on the Sesderma page does.

How does the Lovi fit level for Azelac RU Serum by Sesderma compare across different skin types to CeraVe serums?

Azelac RU Serum by Sesderma achieves a High fit for acne-prone skin and skin with dark spots, matching the High fit levels seen in several CeraVe serums like Resurfacing Retinol Serum. However, Azelac RU Serum drops to a Low fit for dry and dry sensitive skin, whereas CeraVe serums display varying fit levels from Low to Average for those skin types.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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