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Medicube vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Medicube and Sesderma are distinguished skincare brands originating from South Korea and Spain, respectively. The Korean brand is adored for its thoughtfully formulated moisturizers, serums, toners, and masks featuring niacinamide, collagen, and hyaluronic acid, while the Spanish brand is beloved for advanced serums and meticulously engineered formulas. Both serve distinct needs, as the former suits dry and oily acne-prone skin best with targeted solutions like the AGE-R Booster Gel and Deep Lifting Peptide Eye Cream, whereas the latter suits sensitive, hyperpigmented, and aging skin best through products such as the Azelac RU Serum. Ultimately, they differ in their foundational ingredients and geographical origins, yet each delivers profound results through specialized active compounds.

Medicube is a Korean skincare brand founded in 2016 and owned by APR Corp..

medicubereviews.co.ukglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Medicube and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Medicube vs Sesderma products

Medicube vs Sesderma serums and treatments

Questions and answers

Medicube or Sesderma: which is better?

Medicube offers a wider selection of products across multiple categories with generally high Lovi fit levels for dry, oily, and acne-prone skin, whereas Sesderma features a more limited range on this page. Medicube uses key ingredients like Niacinamide, Hyaluronic acid, and Collagen, which help with hydration and reducing pigmentation.

The British Journal of Dermatology, 2002Antioxidants, 2021

What is the difference between Medicube and Sesderma?

Medicube offers a large variety of products featuring key ingredients like niacinamide and hyaluronic acid, whereas Sesderma currently features only Azelac RU Serum on this page. Lovi rates Medicube as a Superior fit for dry skin, oily skin, and oily acne-prone skin.

The British Journal of Dermatology, 2002Dermatologic Therapy, 2022

Which is more affordable, Medicube or Sesderma?

The products on this page for Medicube have reviews mentioning small quantity and pricing issues, while no pricing information is available on this page for Sesderma.

Which causes fewer breakouts, Medicube or Sesderma?

Medicube offers many products on this page for acne-prone skin, such as the Zero Pore Pad, while Sesderma features only Azelac RU Serum. Reviewers note that Medicube products may sometimes cause irritation and breakouts.

Between Medicube and Sesderma, which brand was founded earlier and in which countries were they established?

Sesderma was founded earlier in Spain in 1989, while Medicube was established later in South Korea in 2016.

How do the fragrance options differ between the skincare products offered by Medicube and Sesderma?

Medicube offers mostly fragrance-free products, with only 2 out of 25 products on this page containing fragrance, whereas Sesderma includes fragrance in its products.

Which brand offers a wider variety of products on this page, and what are their respective company owners?

Medicube offers a wider variety of products on this page, with 25 products compared to Sesderma's 1 product. Medicube is owned by APR Corp., while Sesderma is owned by Grupo Sesderma.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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