No7 Protect & Perfect Intense Advanced Night Cream for acne-prone skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Retinyl palmitate-loaded non-ionic lamellar liquid crystalline systems provided a significant reduction of orbicular wrinkles in human volunteers compared to systems without retinyl palmitate.

  Colloids and Surfaces. B, Biointerfaces, 2011

• A vitamin A palmitate and antioxidant-containing oil-based moisturizer improved fine lines, wrinkles, pigmentation, tone, texture, dryness, firmness, and clarity across various body sites compared to a no-treatment group over 12 weeks.

  Journal of Cosmetic Dermatology, 2013

• Retinyl palmitate ethosomal hydrogel reduced non-inflammatory and total acne lesion counts significantly better than marketed tretinoin while improving tolerability with minimal skin irritation in patients with acne vulgaris.

  International Journal of Nanomedicine, 2021

• Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

  Dermatologic Therapy, 2022

• A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic.

  Journal of Cosmetic Dermatology, 2021

• Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls.

  Frontiers in Medicine, 2024

• Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls.

  Journal of Agricultural and Food Chemistry, 2020

• Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question.

  The Journal of Clinical and Aesthetic Dermatology, 2021

• A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women.

  The British Journal of Dermatology, 2010

• A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation.

  International Journal of Cosmetic Science, 2024

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

• Rice protein hydrolysate and its characteristic peptides Leu-Leu-Lys, Leu-Pro-Lys, and pyroGlu-Lys reduced melanin content, tyrosinase activity, and ROS production in UVB-induced human epidermal melanocyte PIG1 cells by regulating the JNK/Β-Trcp/NFΗB-p65/MITF signaling pathway and lowering TRP-1 and TRP-2 expression.

  Food & Function, 2020

Why other moisturizers fit acne-prone skin better

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.

  Journal of Cosmetic Dermatology, 2024

• A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks.

  Journal of Cosmetic Dermatology, 2022

Ingredients

Water, Glycerin, Butyrospermum Parkii Butter Shea Butter, Sorbitan Stearate, Dimethicone, Cetearyl Alcohol, Caprylic Capric Triglyceride, Ethylhexyl Stearate, Polyacrylamide, Butylene Glycol, C13-14 Isoparaffin, Alcohol Denat, Phenoxyethanol, Dimethiconol, Tribehenin, Dipropylene Glycol, Sucrose Cocoate, Methylparaben, Carbomer, Laureth-7, Propylene Glycol, Tocopheryl Acetate, Sodium Hyaluronate, Ascorbyl Glucoside, Ethylparaben, Retinyl Palmitate, Xanthan Gum, Hydrolyzed Rice Protein, Tetrasodium Edta, Sorbitan Laurate, Potassium Hydroxide, Panax Ginseng Root Extract, Dimethylmethoxy Chromanol, Medicago Sativa Extract, Polysorbate 20, Hydroxyethylcellulose, Acetyl Dipeptide-1 Cetyl Ester, Morus Alba Leaf Extract, Lindera Strychnifolia Root Extract, Sodium Benzoate, Tocopherol, Ethylhexylglycerin, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.