Shiseido White Lucent Brightening Gel Cream for sensitive skin

How to apply

Questions and answers

What the research says

• Concurrent treatment with 3-O-ethyl ascorbic acid and cannabigerol in UVB-irradiated human keratinocytes prevents membrane structure alterations, promotes cell survival, enhances antioxidant enzyme activity and GSH- and Trx-dependent systems, reduces lipid and protein oxidative modifications, and exerts anti-inflammatory effects.

  Free Radical Biology & Medicine, 2025

• A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo.

  Polymers, 2023

• A topical formulation containing panthenol, niacinamide, and dipotassium glycyrrhizate increased skin hydration by 74.1% and reduced transepidermal water loss by 13.5% at 28 days compared to baseline and untreated control in 35 individuals with xerosis.

  Journal of Cosmetic Dermatology, 2026

• Potassium 4-methoxysalicylate (4MSK) suppresses melanin content, promotes keratinocyte differentiation, increases skin lightness in pigmented and non-pigmented cheek areas, and reduces the desquamation area ratio.

  Journal of Cosmetic Dermatology, 2025

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism.

  Evidence-based Complementary and Alternative Medicine, 2015

• Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo.

  Experimental Dermatology, 2015

• Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.

  Advanced Science, 2025

• A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks.

  International Journal of Cosmetic Science, 2011

• Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects.

  Frontiers in Physiology, 2019

• Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid.

  AAPS PharmSciTech, 2021

Ingredients

Water, Butylene Glycol, Glycerin, Dimethicone, Sd Alcohol 40-B Alcohol Denat, Triethylhexanoin, Peg Ppg-14 7 Dimethyl Ether, Hydrogenated Polydecene, Behenyl Alcohol, Stearyl Alcohol, Myristyl Myristate, Glyceryl Stearate Se, Trehalose, Potassium Methoxysalicylate, Phytosteryl Macadamiate, Methyl Methacrylate Crosspolymer, Polysorbate 60, Peg-40 Stearate, Phenoxyethanol, Dimethylacrylamide Sodium Acryloyldimethyltaurate Crosspolymer, Hydrogenated Palm Oil, Palm Kernel Oil, Palm Oil, Sorbitan Tristearate, Trisodium Edta, Erythritol, Peg Ppg-17 4 Dimethyl Ether, Sodium Citrate, Parfum, Dipotassium Glycyrrhizate, 2-O-Ethyl Ascorbic Acid, Alcohol, Silica, Xanthan Gum, Caffeine, Linalool, Citric Acid, Sodium Metaphosphate, Ppg-3 Dipivalate, Hdi Trimethylol Hexyllactone Crosspolymer, Tocopherol, Citronellol, Sodium Metabisulfite, Geraniol, Angelica Keiskei Stem Extract Leaf, Limonene, Paeonia Albiflora Root Extract, Crataegus Monogyna Flower Extract, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Fructose, Rehmannia Chinensis Root Extract, Iron Oxides Ci 77491, Prunus Yedoensis Leaf Extract, Ziziphus Jujuba Fruit Extract, Pyrola Incarnata Extract, Potentilla Erecta Root Extract, Polyquaternium-51, Benzoic Acid

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.