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Clinique vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Clinique and Sesderma are distinguished skincare brands that offer thoughtful solutions for diverse complexions. The American brand is widely loved for its moisturizers, serums, makeup removers, and eye products featuring hyaluronic acid, glycerin, and caffeine, making it best suited for dry sensitive and oily skin. Conversely, the Spanish brand is beloved for its advanced serums and meticulously engineered formulas that best suit sensitive, hyperpigmented, and aging skin. While both emphasize targeted care, they differ in their foundational ingredients and regional heritage.

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

en.wikipedia.orgelcompanies.combusinesswire.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Clinique and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Clinique vs Sesderma products

Questions and answers

Clinique or Sesderma: which is better?

Clinique is generally a better choice for most shoppers on this page, offering a wide range of fragrance-free options suited for dry sensitive, oily, and sensitive skin types. Sesderma only features a single serum on this page, which includes fragrance and has lower fit levels for dry skin.

What is the difference between Clinique and Sesderma?

Clinique offers a wide range of fragrance-free products on this page with High Lovi fit levels for dry sensitive, oily, and sensitive skin, while Sesderma features just one serum that lists fragrance. Additionally, Clinique relies on key ingredients like hyaluronic acid, glycerin, caffeine, and salicylic acid.

Dermatologic Therapy, 2022Skin Pharmacology and Physiology, 2013

Which is more affordable, Clinique or Sesderma?

The products on this page for Clinique face negative reviews for a high price point, but affordability details are not available for Sesderma.

Which causes fewer breakouts, Clinique or Sesderma?

Clinique is unlikely to cause breakouts for most users, though shoppers sometimes note occasional breakouts with the products on this page. Sesderma has only one product on this page, which is not rated for breakout risk.

Which brand has more fragrance-free products, Clinique or Sesderma?

Clinique has more fragrance-free products, as every single product on the page lists no fragrance in its ingredients. In contrast, Sesderma has fragrance in its only product listed on the page.

Which brand was founded earlier and in which country, Clinique or Sesderma?

Clinique was founded earlier in 1968 in the United States, whereas Sesderma was founded in 1989 in Spain.

What key ingredients are found across Clinique products?

Clinique features key ingredients across its products such as hyaluronic acid, glycerin, caffeine, and salicylic acid. These components help provide hydration and support overall skin quality.

Dermatologic Therapy, 2022Skin Pharmacology and Physiology, 2013

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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