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Clinique vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Clinique and Sesderma are distinguished skincare brands that offer thoughtful solutions for diverse complexions. The American brand is widely loved for its moisturizers, serums, makeup removers, and eye products featuring hyaluronic acid, glycerin, and caffeine, making it best suited for dry sensitive and oily skin. Conversely, the Spanish brand is beloved for its advanced serums and meticulously engineered formulas that best suit sensitive, hyperpigmented, and aging skin. While both emphasize targeted care, they differ in their foundational ingredients and regional heritage.

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

en.wikipedia.orgelcompanies.combusinesswire.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Clinique and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Clinique vs Sesderma products

Questions and answers

Clinique or Sesderma: which is better?

Clinique is the better choice for most shoppers on this page, offering a wide range of fragrance-free options with a High Lovi fit for dry sensitive, oily, and mature skin, whereas Sesderma currently features only a single serum containing fragrance.

What is the difference between Clinique and Sesderma?

Clinique offers a wide range of fragrance-free products on this page with various fit levels for multiple skin types, featuring key ingredients like hyaluronic acid and caffeine. In contrast, Sesderma features a single serum on this page that contains fragrance. Topical hyaluronic acid helps improve skin quality and signs of aging.

Dermatologic Therapy, 2022

Which is more affordable, Clinique or Sesderma?

The products on this page for Clinique often have a high price point according to reviewers, while there is no pricing information available for Sesderma on this page.

Which causes fewer breakouts, Clinique or Sesderma?

Clinique has products on this page with an acne-prone skin fit level of High, whereas Sesderma is not noted for breakout control. The products on this page from Clinique help provide oil-controlling and smoothing moisturizers, but reviewers sometimes note that the brand causes breakouts.

Which brand has been on the market longer, Clinique or Sesderma?

Clinique has been on the market longer, having been founded in the United States in 1968, whereas Sesderma was founded in Spain in 1989.

Do both Clinique and Sesderma offer products that are completely fragrance-free?

Clinique offers products that are completely fragrance-free, as every product on the Clinique page lists no fragrance in its ingredients. In contrast, Sesderma features a product with fragrance, as the Azelac RU Serum on its page contains fragrance.

Which brand offers more options for serums, Clinique or Sesderma?

Clinique offers more options for serums, featuring several treatments on this page such as the Smart Clinical Repair Wrinkle Correcting Serum, Even Better Clinical Dark Spot Corrector, and Clarifying Do-Over Peel. In comparison, Sesderma features only one serum on this page, the Azelac RU Serum.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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