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Clinique vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Clinique and Sesderma are distinguished skincare brands that offer thoughtful solutions for diverse complexions. The American brand is widely loved for its moisturizers, serums, makeup removers, and eye products featuring hyaluronic acid, glycerin, and caffeine, making it best suited for dry sensitive and oily skin. Conversely, the Spanish brand is beloved for its advanced serums and meticulously engineered formulas that best suit sensitive, hyperpigmented, and aging skin. While both emphasize targeted care, they differ in their foundational ingredients and regional heritage.

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

en.wikipedia.orgelcompanies.combusinesswire.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Clinique and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Clinique vs Sesderma products

Questions and answers

Clinique or Sesderma: which is better?

Clinique is better suited for most shoppers on this page, offering a wide range of fragrance-free products with high Lovi fit levels for various skin types like dry sensitive skin and oily skin. In contrast, Sesderma features only one product on this page, which contains fragrance.

What is the difference between Clinique and Sesderma?

Clinique offers a wide range of fragrance-free products that Lovi rates high for dry sensitive, oily, and oily acne-prone skin, whereas Sesderma features an Azelac RU Serum that contains fragrance. Shoppers often mention Clinique for hydrating moisturizers and gentle cleansers.

Which is more affordable, Clinique or Sesderma?

Reviewers note that Clinique has a high price point. The products on this page for Sesderma do not include enough pricing information to make a comparison.

Which causes fewer breakouts, Clinique or Sesderma?

Clinique features products on this page with a Lovi fit level of High for acne-prone skin, such as Clarifying Do-Over Peel, while Sesderma has Azelac RU Serum with a High fit for acne-prone skin. Reviewers note that Clinique sometimes causes breakouts, but there is no review data on this for Sesderma.

How does the founding year and country of origin compare between Clinique and Sesderma?

Clinique was founded in the United States in 1968, whereas Sesderma was founded in Spain in 1989.

Which brand offers products with no fragrance in their ingredients, Clinique or Sesderma?

Clinique offers products with no fragrance in their ingredients, as every product on the Clinique page lists no fragrance, whereas the Azelac RU Serum by Sesderma includes fragrance.

What are the main key ingredients found across Clinique's products?

The main key ingredients found across Clinique's products on this page include hyaluronic acid, glycerin, caffeine, and salicylic acid.

Dermatologic Therapy, 2022Skin Pharmacology and Physiology, 2013

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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