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Clinique vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Clinique and Sesderma are distinguished skincare brands that offer thoughtful solutions for diverse complexions. The American brand is widely loved for its moisturizers, serums, makeup removers, and eye products featuring hyaluronic acid, glycerin, and caffeine, making it best suited for dry sensitive and oily skin. Conversely, the Spanish brand is beloved for its advanced serums and meticulously engineered formulas that best suit sensitive, hyperpigmented, and aging skin. While both emphasize targeted care, they differ in their foundational ingredients and regional heritage.

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

en.wikipedia.orgelcompanies.combusinesswire.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Clinique and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Clinique vs Sesderma products

Questions and answers

Clinique or Sesderma: which is better?

Clinique is better for shoppers seeking a broad range of fragrance-free products, offering items that Lovi rates as having High or Superior fit for sensitive, dry sensitive, and oily skin types. Topical hyaluronic acid, featured across the products on this page, helps improve skin quality and signs of aging.

Dermatologic Therapy, 2022

What is the difference between Clinique and Sesderma?

Clinique features a large fragrance-free skincare range with key ingredients like hyaluronic acid and caffeine, while Sesderma offers a single serum that contains fragrance. For skin types, Lovi rates Clinique with a High fit for dry sensitive, oily, and sensitive skin, whereas Sesderma has no top-fitting skin types listed on this page.

Dermatologic Therapy, 2022Skin Pharmacology and Physiology, 2013

Which is more affordable, Clinique or Sesderma?

Reviewers note that Clinique has a high price point. The page facts do not provide pricing information for Sesderma.

Which causes fewer breakouts, Clinique or Sesderma?

Reviewers note that Clinique sometimes causes breakouts, while Sesderma has no breakout reports for its products on this page.

Which brand has been established longer, Clinique or Sesderma?

Clinique has been established longer, having been founded in 1968 in the United States, whereas Sesderma was founded in 1989 in Spain.

Do Clinique products contain fragrance compared to Sesderma's Azelac RU Serum?

Every product on the Clinique page lists no fragrance in its ingredients, whereas Sesderma's Azelac RU Serum contains fragrance.

Which brand offers a wider range of products on this page?

Clinique offers a wider range of products on this page, featuring numerous moisturizers, cleansers, and serums, while Sesderma includes only a single serum. Every product on the Clinique page lists no fragrance in its ingredients.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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