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Clinique vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Clinique and Sesderma are distinguished skincare brands that offer thoughtful solutions for diverse complexions. The American brand is widely loved for its moisturizers, serums, makeup removers, and eye products featuring hyaluronic acid, glycerin, and caffeine, making it best suited for dry sensitive and oily skin. Conversely, the Spanish brand is beloved for its advanced serums and meticulously engineered formulas that best suit sensitive, hyperpigmented, and aging skin. While both emphasize targeted care, they differ in their foundational ingredients and regional heritage.

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

en.wikipedia.orgelcompanies.combusinesswire.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Clinique and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Clinique vs Sesderma products

Questions and answers

Clinique or Sesderma: which is better?

Clinique is better if you want a wide variety of fragrance-free moisturizers, cleansers, and serums that Lovi rates as having a High fit for dry sensitive, oily, and mature skin. Sesderma only has one product featured on this page, which is formulated with fragrance. Topical hyaluronic acid helps improve skin quality and signs of aging.

Dermatologic Therapy, 2022

What is the difference between Clinique and Sesderma?

Clinique features a large range of fragrance-free moisturizers, cleansers, and serums containing key ingredients like hyaluronic acid and glycerin, whereas Sesderma is represented on this page by just a single fragranced serum. The products on this page help provide hydration and target skin concerns with varying Lovi fit levels depending on your skin type.

Dermatologic Therapy, 2022

Which is more affordable, Clinique or Sesderma?

Reviewers on this page often mention a high price point for the products on this page from Clinique. Sesderma has only one product on this page, and price comparisons are not provided.

Which causes fewer breakouts, Clinique or Sesderma?

Reviewers note that Clinique sometimes causes breakouts, while no breakout data is mentioned for Sesderma on this page. Clinique products on this page help hydrate and smooth skin using key ingredients like hyaluronic acid and glycerin.

Dermatologic Therapy, 2022

Which brand has been on the market longer, Clinique or Sesderma?

Clinique has been on the market longer, having been founded in 1968, while Sesderma was founded in 1989.

Do both Clinique and Sesderma offer products for skin with dark spots?

Yes, both Clinique and Sesderma offer products for skin with dark spots. Clinique includes several targeted formulas on this page, while Sesderma provides options like Azelac RU Serum. Topical hyaluronic acid helps improve skin quality and signs of aging.

Dermatologic Therapy, 2022

Are all Clinique products fragrance-free according to the page?

Yes, every Clinique product on this page lists no fragrance in its ingredients.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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