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Clinique vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Clinique and Sesderma are distinguished skincare brands that offer thoughtful solutions for diverse complexions. The American brand is widely loved for its moisturizers, serums, makeup removers, and eye products featuring hyaluronic acid, glycerin, and caffeine, making it best suited for dry sensitive and oily skin. Conversely, the Spanish brand is beloved for its advanced serums and meticulously engineered formulas that best suit sensitive, hyperpigmented, and aging skin. While both emphasize targeted care, they differ in their foundational ingredients and regional heritage.

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

en.wikipedia.orgelcompanies.combusinesswire.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Clinique and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Clinique vs Sesderma products

Questions and answers

Clinique or Sesderma: which is better?

Clinique is better for a wide range of skin types because the products on this page feature fragrance-free formulas and high Lovi fit levels across multiple categories, whereas Sesderma offers only a single serum here.

What is the difference between Clinique and Sesderma?

Clinique features a large variety of fragrance-free moisturizers, cleansers, and serums that Lovi rates with High or Superior fit levels for sensitive, dry sensitive, and oily skin types. In contrast, the Sesderma products on this page include fragrance and focus primarily on targeted serums like Azelac RU Serum.

Which is more affordable, Clinique or Sesderma?

Reviewers of Clinique frequently mention its high price point, while affordability details for Sesderma are not noted on this page.

Which causes fewer breakouts, Clinique or Sesderma?

Clinique is Lovi-rated for acne-prone skin with various fit levels ranging from High to Caution across the products on this page, while Sesderma features only Azelac RU Serum which has a High fit level for acne-prone skin.

Which brand has been around longer, Clinique or Sesderma?

Clinique has been around longer, having been founded in the United States in 1968, whereas Sesderma was founded in Spain in 1989.

Do all Clinique products lack fragrance in their ingredients?

Yes, every product on the Clinique page lists no fragrance in its ingredients.

Which brand offers products specifically formulated with a Superior fit for mature skin?

Clinique features the Smart Clinical Repair Lifting Face + Neck Cream, which achieves a Superior fit for mature skin among the products on this page.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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