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Clinique vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Clinique and Sesderma are distinguished skincare brands originating from America and Spain, respectively. The American brand is widely loved for its thoughtful range of moisturizers, serums, makeup removers, and eye products, which thoughtfully combine ingredients like hyaluronic acid, glycerin, and caffeine, while the Spanish brand is beloved for its advanced serums and meticulously engineered formulas. Clinique suits dry skin and oily skin best, whereas Sesderma suits sensitive, hyperpigmented, and aging skin types best. These two options differ primarily in their formulation approaches and regional heritage, offering tailored solutions for diverse complexions.

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

en.wikipedia.orgelcompanies.combusinesswire.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Clinique and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Clinique vs Sesderma products

Questions and answers

Clinique or Sesderma: which is better?

Clinique is better because it offers a much wider variety of fragrance-free products on this page tailored to different skin types, whereas Sesderma features only a single serum. Reviewers frequently mention that Clinique provides hydrating, lightweight moisturizers and gentle cleansers, though it has a higher price point.

What is the difference between Clinique and Sesderma?

Clinique offers a wide variety of fragrance-free moisturizers, cleansers, and serums that Lovi rates with high to average fit levels for dry, oily, and combination skin, while Sesderma features just one serum on this page that contains fragrance. Hyaluronic acid helps hydrate the skin across Clinique products.

Dermatologic Therapy, 2022

Which is more affordable, Clinique or Sesderma?

Reviewers note that Clinique has a high price point, but the page facts do not provide pricing information to compare its affordability with Sesderma.

Which causes fewer breakouts, Clinique or Sesderma?

Clinique may cause breakouts as sometimes noted by reviewers, while the products on this page for Sesderma do not feature user feedback regarding breakouts.

Which brand has been around longer, Clinique or Sesderma?

Clinique has been around longer, having been founded in the United States in 1968, whereas Sesderma was founded in Spain in 1989.

Do Clinique products contain fragrance compared to Sesderma's Azelac RU Serum?

Clinique products on this page list no fragrance in their ingredients, whereas Sesderma's Azelac RU Serum contains fragrance.

Which skin types does Clinique fit best according to its brand-focused routines?

According to its brand-focused routines, Clinique fits dry skin, oily skin, and combination skin best.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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